Serum lipidome associates with neuroimaging features in patients with traumatic brain injury

Thomas, Ilias (författare): School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; School of Information and Engineering, Dalarna University, 79131 Falun, Sweden

Newcombe, Virginia F. J. (författare): Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK

Dickens, Alex M. (författare): Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; Department of Chemistry, University of Turku, Turku, Finland

Richter, Sophie (författare): Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK

Posti, Jussi P. (författare): Neurocenter, Department of Neurosurgery and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland

Maas, Andrew I. R. (författare): Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium

Tenovuo, Olli (författare): Neurocenter, Department of Neurology and Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland

Hyötyläinen, Tuulia, 1971- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik

Büki, Andras, 1966- (författare): Örebro universitet,Institutionen för medicinska vetenskaper

Menon, David K. (författare): Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK

Oresic, Matej, 1967- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland

CENTER-TBI MR subgroup Participants and Investigators, - (bidragsgivare)

(creator_code:org_t)

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin in the brain. We investigated the relationship between traumatic microstructural changes in white matter from magnetic resonance imaging (MRI) and quantitative lipidomic changes from blood serum. The study cohort included 103 patients from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. Diffusion tensor fitting generated fractional anisotropy (FA) and mean diffusivity (MD) maps for the MRI scans while ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry was applied to analyze the lipidome. Increasing severity of TBI was associated with higher MD and lower FA values, which scaled with different lipidomic signatures. There appears to be consistent patterns of lipid changes associating with the specific microstructure changes in the CNS white matter, but also regional specificity, suggesting that blood-based lipidomics may provide an insight into the underlying pathophysiology of TBI.

Av författaren/redakt...: Thomas, Ilias; Newcombe, Virgin ...; Dickens, Alex M.; Richter, Sophie; Posti, Jussi P.; Maas, Andrew I. ...; visa fler...; Tenovuo, Olli; Hyötyläinen, Tuu ...; Büki, Andras, 19 ...; Menon, David K.; Oresic, Matej, 1 ...; CENTER-TBI MR su ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

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