Sökning: WFRF:(Colhoun Helen M.) > Genome-Wide Associa...
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000 | 08723naa a2202293 4500 | |
001 | oai:DiVA.org:uu-174593 | |
003 | SwePub | |
008 | 120522s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1745932 URI |
024 | 7 | a https://doi.org/10.1371/journal.pgen.10025842 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Pattaro, Cristian4 aut |
245 | 1 0 | a Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function |
264 | c 2012-03-29 | |
264 | 1 | b Public Library of Science (PLoS),c 2012 |
338 | a electronic2 rdacarrier | |
520 | a Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genomewide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Koettgen, Anna4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Garnaas, Maija4 aut |
700 | 1 | a Boeger, Carsten A.4 aut |
700 | 1 | a Fuchsberger, Christian4 aut |
700 | 1 | a Olden, Matthias4 aut |
700 | 1 | a Chen, Ming-Huei4 aut |
700 | 1 | a Tin, Adrienne4 aut |
700 | 1 | a Taliun, Daniel4 aut |
700 | 1 | a Li, Man4 aut |
700 | 1 | a Gao, Xiaoyi4 aut |
700 | 1 | a Gorski, Mathias4 aut |
700 | 1 | a Yang, Qiong4 aut |
700 | 1 | a Hundertmark, Claudia4 aut |
700 | 1 | a Foster, Meredith C.4 aut |
700 | 1 | a O'Seaghdha, Conall M.4 aut |
700 | 1 | a Glazer, Nicole4 aut |
700 | 1 | a Isaacs, Aaron4 aut |
700 | 1 | a Liu, Ching-Ti4 aut |
700 | 1 | a Smith, Albert V.4 aut |
700 | 1 | a O'Connell, Jeffrey R.4 aut |
700 | 1 | a Struchalin, Maksim4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Li, Guo4 aut |
700 | 1 | a Johnson, Andrew D.4 aut |
700 | 1 | a Gierman, Hinco J.4 aut |
700 | 1 | a Feitosa, Mary4 aut |
700 | 1 | a Hwang, Shih-Jen4 aut |
700 | 1 | a Atkinson, Elizabeth J.4 aut |
700 | 1 | a Lohman, Kurt4 aut |
700 | 1 | a Cornelis, Marilyn C.4 aut |
700 | 1 | a Johansson, Åsau Uppsala universitet,Genomik,Gyllensten4 aut0 (Swepub:uu)asjoh108 |
700 | 1 | a Toenjes, Anke4 aut |
700 | 1 | a Dehghan, Abbas4 aut |
700 | 1 | a Chouraki, Vincent4 aut |
700 | 1 | a Holliday, Elizabeth G.4 aut |
700 | 1 | a Sorice, Rossella4 aut |
700 | 1 | a Kutalik, Zoltan4 aut |
700 | 1 | a Lehtimaeki, Terho4 aut |
700 | 1 | a Esko, Tonu4 aut |
700 | 1 | a Deshmukh, Harshal4 aut |
700 | 1 | a Ulivi, Sheila4 aut |
700 | 1 | a Chu, Audrey Y.4 aut |
700 | 1 | a Murgia, Federico4 aut |
700 | 1 | a Trompet, Stella4 aut |
700 | 1 | a Imboden, Medea4 aut |
700 | 1 | a Kollerits, Barbara4 aut |
700 | 1 | a Pistis, Giorgio4 aut |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a Launer, Lenore J.4 aut |
700 | 1 | a Aspelund, Thor4 aut |
700 | 1 | a Eiriksdottir, Gudny4 aut |
700 | 1 | a Mitchell, Braxton D.4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Schmidt, Helena4 aut |
700 | 1 | a Cavalieri, Margherita4 aut |
700 | 1 | a Rao, Madhumathi4 aut |
700 | 1 | a Hu, Frank B.4 aut |
700 | 1 | a Demirkan, Ayse4 aut |
700 | 1 | a Oostra, Ben A.4 aut |
700 | 1 | a de Andrade, Mariza4 aut |
700 | 1 | a Turner, Stephen T.4 aut |
700 | 1 | a Ding, Jingzhong4 aut |
700 | 1 | a Andrews, Jeanette S.4 aut |
700 | 1 | a Freedman, Barry I.4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Doering, Angela4 aut |
700 | 1 | a Wichmann, H. -Erich4 aut |
700 | 1 | a Kolcic, Ivana4 aut |
700 | 1 | a Zemunik, Tatijana4 aut |
700 | 1 | a Boban, Mladen4 aut |
700 | 1 | a Minelli, Cosetta4 aut |
700 | 1 | a Wheeler, Heather E.4 aut |
700 | 1 | a Igl, Wilmaru Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut |
700 | 1 | a Zaboli, Ghazalu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut |
700 | 1 | a Wild, Sarah H.4 aut |
700 | 1 | a Wright, Alan F.4 aut |
700 | 1 | a Campbell, Harry4 aut |
700 | 1 | a Ellinghaus, David4 aut |
700 | 1 | a Nothlings, Ute4 aut |
700 | 1 | a Jacobs, Gunnar4 aut |
700 | 1 | a Biffar, Reiner4 aut |
700 | 1 | a Endlich, Karlhans4 aut |
700 | 1 | a Ernst, Florian4 aut |
700 | 1 | a Homuth, Georg4 aut |
700 | 1 | a Kroemer, Heyo K.4 aut |
700 | 1 | a Nauck, Matthias4 aut |
700 | 1 | a Stracke, Sylvia4 aut |
700 | 1 | a Voelker, Uwe4 aut |
700 | 1 | a Voelzke, Henry4 aut |
700 | 1 | a Kovacs, Peter4 aut |
700 | 1 | a Stumvoll, Michael4 aut |
700 | 1 | a Magi, Reedik4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Aulchenko, Yurii S.4 aut |
700 | 1 | a Polasek, Ozren4 aut |
700 | 1 | a Hastie, Nick4 aut |
700 | 1 | a Vitart, Veronique4 aut |
700 | 1 | a Helmer, Catherine4 aut |
700 | 1 | a Wang, Jie Jin4 aut |
700 | 1 | a Ruggiero, Daniela4 aut |
700 | 1 | a Bergmann, Sven4 aut |
700 | 1 | a Kaehoenen, Mika4 aut |
700 | 1 | a Viikari, Jorma4 aut |
700 | 1 | a Nikopensius, Tiit4 aut |
700 | 1 | a Province, Michael4 aut |
700 | 1 | a Ketkar, Shamika4 aut |
700 | 1 | a Colhoun, Helen4 aut |
700 | 1 | a Doney, Alex4 aut |
700 | 1 | a Robino, Antonietta4 aut |
700 | 1 | a Giulianini, Franco4 aut |
700 | 1 | a Kraemer, Bernhard K.4 aut |
700 | 1 | a Portas, Laura4 aut |
700 | 1 | a Ford, Ian4 aut |
700 | 1 | a Buckley, Brendan M.4 aut |
700 | 1 | a Adam, Martin4 aut |
700 | 1 | a Thun, Gian-Andri4 aut |
700 | 1 | a Paulweber, Bernhard4 aut |
700 | 1 | a Haun, Margot4 aut |
700 | 1 | a Sala, Cinzia4 aut |
700 | 1 | a Metzger, Marie4 aut |
700 | 1 | a Mitchell, Paul4 aut |
700 | 1 | a Ciullo, Marina4 aut |
700 | 1 | a Kim, Stuart K.4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Raitakari, Olli4 aut |
700 | 1 | a Metspalu, Andres4 aut |
700 | 1 | a Palmer, Colin4 aut |
700 | 1 | a Gasparini, Paolo4 aut |
700 | 1 | a Pirastu, Mario4 aut |
700 | 1 | a Jukema, J. Wouter4 aut |
700 | 1 | a Probst-Hensch, Nicole M.4 aut |
700 | 1 | a Kronenberg, Florian4 aut |
700 | 1 | a Toniolo, Daniela4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Shuldiner, Alan R.4 aut |
700 | 1 | a Coresh, Josef4 aut |
700 | 1 | a Schmidt, Reinhold4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Siscovick, David S.4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Borecki, Ingrid4 aut |
700 | 1 | a Kardia, Sharon L. R.4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Curhan, Gary C.4 aut |
700 | 1 | a Rudan, Igor4 aut |
700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Genomik,Gyllensten4 aut0 (Swepub:uu)ulfgyll |
700 | 1 | a Wilson, James F.4 aut |
700 | 1 | a Franke, Andre4 aut |
700 | 1 | a Pramstaller, Peter P.4 aut |
700 | 1 | a Rettig, Rainer4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Witteman, Jacqueline C. M.4 aut |
700 | 1 | a Hayward, Caroline4 aut |
700 | 1 | a Ridker, Paul4 aut |
700 | 1 | a Parsa, Afshin4 aut |
700 | 1 | a Bochud, Murielle4 aut |
700 | 1 | a Heid, Iris M.4 aut |
700 | 1 | a Goessling, Wolfram4 aut |
700 | 1 | a Chasman, Daniel I.4 aut |
700 | 1 | a Kao, W. H. Linda4 aut |
700 | 1 | a Fox, Caroline S.4 aut |
710 | 2 | a Uppsala universitetb Genomik4 org |
773 | 0 | t PLoS Geneticsd : Public Library of Science (PLoS)g 8:3, s. e1002584-q 8:3<e1002584-x 1553-7390x 1553-7404 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:529175/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002584&type=printable |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-174593 |
856 | 4 8 | u https://doi.org/10.1371/journal.pgen.1002584 |
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