Sökning: WFRF:(Dawson Joseph) > Individual common v...
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000 | 08184naa a2201933 4500 | |
001 | oai:gup.ub.gu.se/160896 | |
003 | SwePub | |
008 | 240910s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1608962 URI |
024 | 7 | a https://doi.org/10.1093/hmg/dds3012 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Anney, Richard4 aut |
245 | 1 0 | a Individual common variants exert weak effects on the risk for autism spectrum disorders. |
264 | c 2012-07-26 | |
264 | 1 | b Oxford University Press (OUP),c 2012 |
520 | a While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASD), the contribution of common variation to ASD risk is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating association of individual SNPs, we also sought evidence that common variants, en masse, might affect risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest p-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. By contrast, allele-scores derived from the transmission of common alleles to Stage 1 cases significantly predict case-status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele-score results, it is reasonable to conclude that common variants affect ASD risk but their individual effects are modest. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
700 | 1 | a Klei, Lambertus4 aut |
700 | 1 | a Pinto, Dalila4 aut |
700 | 1 | a Almeida, Joana4 aut |
700 | 1 | a Bacchelli, Elena4 aut |
700 | 1 | a Baird, Gillian4 aut |
700 | 1 | a Bolshakova, Nadia4 aut |
700 | 1 | a Bölte, Sven4 aut |
700 | 1 | a Bolton, Patrick F.4 aut |
700 | 1 | a Bourgeron, Thomas4 aut |
700 | 1 | a Brennan, Sean4 aut |
700 | 1 | a Brian, Jessica4 aut |
700 | 1 | a Casey, Jillian4 aut |
700 | 1 | a Conroy, Judith4 aut |
700 | 1 | a Correia, Catarina4 aut |
700 | 1 | a Corsello, Christina4 aut |
700 | 1 | a Crawford, Emily L4 aut |
700 | 1 | a de Jonge, Maretha4 aut |
700 | 1 | a Delorme, Richard4 aut |
700 | 1 | a Duketis, Eftichia4 aut |
700 | 1 | a Duque, Frederico4 aut |
700 | 1 | a Estes, Annette4 aut |
700 | 1 | a Farrar, Penny4 aut |
700 | 1 | a Fernandez, Bridget A4 aut |
700 | 1 | a Folstein, Susan E4 aut |
700 | 1 | a Fombonne, Eric4 aut |
700 | 1 | a Gilbert, John4 aut |
700 | 1 | a Gillberg, Christopher,d 1950u Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre4 aut0 (Swepub:gu)xgilch |
700 | 1 | a Glessner, Joseph T4 aut |
700 | 1 | a Green, Andrew4 aut |
700 | 1 | a Green, Jonathan4 aut |
700 | 1 | a Guter, Stephen J4 aut |
700 | 1 | a Heron, Elizabeth A4 aut |
700 | 1 | a Holt, Richard4 aut |
700 | 1 | a Howe, Jennifer L4 aut |
700 | 1 | a Hughes, Gillian4 aut |
700 | 1 | a Hus, Vanessa4 aut |
700 | 1 | a Igliozzi, Roberta4 aut |
700 | 1 | a Jacob, Suma4 aut |
700 | 1 | a Kenny, Graham P4 aut |
700 | 1 | a Kim, Cecilia4 aut |
700 | 1 | a Kolevzon, Alexander4 aut |
700 | 1 | a Kustanovich, Vlad4 aut |
700 | 1 | a Lajonchere, Clara M4 aut |
700 | 1 | a Lamb, Janine A4 aut |
700 | 1 | a Law-Smith, Miriam4 aut |
700 | 1 | a Leboyer, Marion4 aut |
700 | 1 | a Le Couteur, Ann4 aut |
700 | 1 | a Leventhal, Bennett L4 aut |
700 | 1 | a Liu, Xiao-Qing4 aut |
700 | 1 | a Lombard, Frances4 aut |
700 | 1 | a Lord, Catherine4 aut |
700 | 1 | a Lotspeich, Linda4 aut |
700 | 1 | a Lund, Sabata C4 aut |
700 | 1 | a Magalhaes, Tiago R4 aut |
700 | 1 | a Mantoulan, Carine4 aut |
700 | 1 | a McDougle, Christopher J4 aut |
700 | 1 | a Melhem, Nadine M4 aut |
700 | 1 | a Merikangas, Alison4 aut |
700 | 1 | a Minshew, Nancy J4 aut |
700 | 1 | a Mirza, Ghazala K4 aut |
700 | 1 | a Munson, Jeff4 aut |
700 | 1 | a Noakes, Carolyn4 aut |
700 | 1 | a Nygren, Gudrun,d 1957u Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre4 aut0 (Swepub:gu)xnygrg |
700 | 1 | a Papanikolaou, Katerina4 aut |
700 | 1 | a Pagnamenta, Alistair T4 aut |
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700 | 1 | a Posey, David J4 aut |
700 | 1 | a Poustka, Fritz4 aut |
700 | 1 | a Ragoussis, Jiannis4 aut |
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700 | 1 | a Renshaw, Katy4 aut |
700 | 1 | a Roberts, Wendy4 aut |
700 | 1 | a Roeder, Kathryn4 aut |
700 | 1 | a Roge, Bernadette4 aut |
700 | 1 | a Rutter, Michael L4 aut |
700 | 1 | a Schlitt, Sabine4 aut |
700 | 1 | a Shah, Naisha4 aut |
700 | 1 | a Sheffield, Val C4 aut |
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700 | 1 | a Sousa, Inês4 aut |
700 | 1 | a Stoppioni, Vera4 aut |
700 | 1 | a Sykes, Nuala4 aut |
700 | 1 | a Tancredi, Raffaella4 aut |
700 | 1 | a Thompson, Ann P4 aut |
700 | 1 | a Thomson, Susanne4 aut |
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700 | 1 | a Tsiantis, John4 aut |
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700 | 1 | a Wing, Kirsty4 aut |
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700 | 1 | a Bailey, Anthony J4 aut |
700 | 1 | a Battaglia, Agatino4 aut |
700 | 1 | a Cantor, Rita M4 aut |
700 | 1 | a Coon, Hilary4 aut |
700 | 1 | a Cuccaro, Michael L4 aut |
700 | 1 | a Dawson, Geraldine4 aut |
700 | 1 | a Ennis, Sean4 aut |
700 | 1 | a Freitag, Christine M4 aut |
700 | 1 | a Geschwind, Daniel H4 aut |
700 | 1 | a Haines, Jonathan L4 aut |
700 | 1 | a Klauck, Sabine M4 aut |
700 | 1 | a McMahon, William M4 aut |
700 | 1 | a Maestrini, Elena4 aut |
700 | 1 | a Miller, Judith4 aut |
700 | 1 | a Monaco, Anthony P4 aut |
700 | 1 | a Nelson, Stanley F4 aut |
700 | 1 | a Nurnberger, John I4 aut |
700 | 1 | a Oliveira, Guiomar4 aut |
700 | 1 | a Parr, Jeremy R4 aut |
700 | 1 | a Pericak-Vance, Margaret A4 aut |
700 | 1 | a Piven, Joseph4 aut |
700 | 1 | a Schellenberg, Gerard D4 aut |
700 | 1 | a Scherer, Stephen W4 aut |
700 | 1 | a Vicente, Astrid M4 aut |
700 | 1 | a Wassink, Thomas H4 aut |
700 | 1 | a Wijsman, Ellen M4 aut |
700 | 1 | a Betancur, Catalina4 aut |
700 | 1 | a Buxbaum, Joseph D4 aut |
700 | 1 | a Cook, Edwin H4 aut |
700 | 1 | a Gallagher, Louise4 aut |
700 | 1 | a Gill, Michael4 aut |
700 | 1 | a Hallmayer, Joachim4 aut |
700 | 1 | a Paterson, Andrew D4 aut |
700 | 1 | a Sutcliffe, James S4 aut |
700 | 1 | a Szatmari, Peter4 aut |
700 | 1 | a Vieland, Veronica J4 aut |
700 | 1 | a Hakonarson, Hakon4 aut |
700 | 1 | a Devlin, Bernie4 aut |
710 | 2 | a Göteborgs universitetb Gillbergcentrum4 org |
773 | 0 | t Human Molecular Geneticsd : Oxford University Press (OUP)g 21:21, s. 4781-92q 21:21<4781-92x 0964-6906x 1460-2083 |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/21/21/4781/17256651/dds301.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/160896 |
856 | 4 8 | u https://doi.org/10.1093/hmg/dds301 |
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