WFRF:(Denton R. E.)
Sökning: WFRF:(Denton R. E.) > (2020-2022) > Describing the curr...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04570naa a2200733 4500 | |
| 001 | oai:gup.ub.gu.se/302331 | |
| 003 | SwePub | |
| 008 | 240528s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3023312 URI |
| 024 | 7 | a https://doi.org/10.1111/mec.157062 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Moser, K. A.4 aut |
| 245 | 1 0 | a Describing the current status of Plasmodium falciparum population structure and drug resistance within mainland Tanzania using molecular inversion probes |
| 264 | c 2020-11-29 | |
| 264 | 1 | b Wiley,c 2021 |
| 520 | a High-throughput Plasmodium genomic data is increasingly useful in assessing prevalence of clinically important mutations and malaria transmission patterns. Understanding parasite diversity is important for identification of specific human or parasite populations that can be targeted by control programmes, and to monitor the spread of mutations associated with drug resistance. An up-to-date understanding of regional parasite population dynamics is also critical to monitor the impact of control efforts. However, this data is largely absent from high-burden nations in Africa, and to date, no such analysis has been conducted for malaria parasites in Tanzania countrywide. To this end, over 1,000 P. falciparum clinical isolates were collected in 2017 from 13 sites in seven administrative regions across Tanzania, and parasites were genotyped at 1,800 variable positions genome-wide using molecular inversion probes. Population structure was detectable among Tanzanian P. falciparum parasites, approximately separating parasites from the northern and southern districts and identifying genetically admixed populations in the north. Isolates from nearby districts were more likely to be genetically related compared to parasites sampled from more distant districts. Known drug resistance mutations were seen at increased frequency in northern districts (including two infections carrying pfk13-R561H), and additional variants with undetermined significance for antimalarial resistance also varied by geography. Malaria Indicator Survey (2017) data corresponded with genetic findings, including average region-level complexity-of-infection and malaria prevalence estimates. The parasite populations identified here provide important information on extant spatial patterns of genetic diversity of Tanzanian parasites, to which future surveys of genetic relatedness can be compared. © 2020 John Wiley & Sons Ltd | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
| 653 | a drug resistance | |
| 653 | a isolation-by-distance | |
| 653 | a malaria | |
| 653 | a molecular inversion probes | |
| 653 | a Plasmodium falciparum | |
| 653 | a population structure | |
| 653 | a Tanzania | |
| 700 | 1 | a Madebe, R. A.4 aut |
| 700 | 1 | a Aydemir, O.4 aut |
| 700 | 1 | a Chiduo, M. G.4 aut |
| 700 | 1 | a Mandara, C. I.4 aut |
| 700 | 1 | a Rumisha, S. F.4 aut |
| 700 | 1 | a Chaky, F.4 aut |
| 700 | 1 | a Denton, M.4 aut |
| 700 | 1 | a Marsh, P. W.4 aut |
| 700 | 1 | a Verity, R.4 aut |
| 700 | 1 | a Watson, O. J.4 aut |
| 700 | 1 | a Ngasala, B.4 aut |
| 700 | 1 | a Mkude, S.4 aut |
| 700 | 1 | a Molteni, F.4 aut |
| 700 | 1 | a Njau, R.4 aut |
| 700 | 1 | a Warsame, Marianu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xwarsm |
| 700 | 1 | a Mandike, R.4 aut |
| 700 | 1 | a Kabanywanyi, A. M.4 aut |
| 700 | 1 | a Mahende, M. K.4 aut |
| 700 | 1 | a Kamugisha, E.4 aut |
| 700 | 1 | a Ahmed, M.4 aut |
| 700 | 1 | a Kavishe, R. A.4 aut |
| 700 | 1 | a Greer, G.4 aut |
| 700 | 1 | a Kitojo, C. A.4 aut |
| 700 | 1 | a Reaves, E. J.4 aut |
| 700 | 1 | a Mlunde, L.4 aut |
| 700 | 1 | a Bishanga, D.4 aut |
| 700 | 1 | a Mohamed, A.4 aut |
| 700 | 1 | a Juliano, J. J.4 aut |
| 700 | 1 | a Ishengoma, D. S.4 aut |
| 700 | 1 | a Bailey, J. A.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin4 org |
| 773 | 0 | t Molecular Ecologyd : Wileyg 30:1, s. 100-113q 30:1<100-113x 0962-1083x 1365-294X |
| 856 | 4 | u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088766 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/302331 |
| 856 | 4 8 | u https://doi.org/10.1111/mec.15706 |
Hitta mer i SwePub
- Av författaren/redakt...
- Moser, K. A.
- Madebe, R. A.
- Aydemir, O.
- Chiduo, M. G.
- Mandara, C. I.
- Rumisha, S. F.
- visa fler...
- Chaky, F.
- Denton, M.
- Marsh, P. W.
- Verity, R.
- Watson, O. J.
- Ngasala, B.
- Mkude, S.
- Molteni, F.
- Njau, R.
- Warsame, Marian
- Mandike, R.
- Kabanywanyi, A. ...
- Mahende, M. K.
- Kamugisha, E.
- Ahmed, M.
- Kavishe, R. A.
- Greer, G.
- Kitojo, C. A.
- Reaves, E. J.
- Mlunde, L.
- Bishanga, D.
- Mohamed, A.
- Juliano, J. J.
- Ishengoma, D. S.
- Bailey, J. A.
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Farmakologi och ...
- Artiklar i publikationen
- Molecular Ecolog ...
- Av lärosätet
- Göteborgs universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
