Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3

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MARC

Fältnamn	Indikatorer	Metadata
000		04925naa a2200949 4500
001		oai:lup.lub.lu.se:fe24832a-21d8-4a12-9d3c-24fb4f672090
003		SwePub
008		160401s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:123530970
024	7	a https://lup.lub.lu.se/record/22542802 URI
024	7	a https://doi.org/10.1038/ng.9582 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1235309702 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a MacGregor, Stuart4 aut
245	1 0	a Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
264		c 2011-10-09
264	1	b Springer Science and Business Media LLC,c 2011
520		a We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and 4,387 control individuals. In this discovery phase, we confirm several previously characterized melanoma-associated loci at MC1R, ASIP and MTAP-CDKN2A. We selected variants at nine loci for replication in three independent case-control studies (Europe: 2,804 subjects with melanoma, 7,618 control subjects; United States 1: 1,804 subjects with melanoma, 1,026 control subjects; United States 2: 585 subjects with melanoma, 6,500 control subjects). The combined meta-analysis of all case-control studies identified a new susceptibility locus at 1q21.3 (rs7412746, P = 9.0 x 10(-11), OR in combined replication cohorts of 0.89 (95% CI 0.85-0.95)). We also show evidence suggesting that melanoma associates with 1q42.12 (rs3219090, P = 9.3 x 10(-8)). The associated variants at the 1q21.3 locus span a region with ten genes, and plausible candidate genes for melanoma susceptibility include ARNT and SETDB1. Variants at the 1q21.3 locus do not seem to be associated with human pigmentation or measures of nevus density.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Montgomery, Grant W.4 aut
700	1	a Liu, Jimmy Z.4 aut
700	1	a Zhao, Zhen Zhen4 aut
700	1	a Henders, Anjali K.4 aut
700	1	a Stark, Mitchell4 aut
700	1	a Schmid, Helen4 aut
700	1	a Holland, Elizabeth A.4 aut
700	1	a Duffy, David L.4 aut
700	1	a Zhang, Mingfeng4 aut
700	1	a Painter, Jodie N.4 aut
700	1	a Nyholt, Dale R.4 aut
700	1	a Maskiell, Judith A.4 aut
700	1	a Jetann, Jodieu Karolinska Institutet4 aut
700	1	a Ferguson, Megan4 aut
700	1	a Cust, Anne E.4 aut
700	1	a Jenkins, Mark A.4 aut
700	1	a Whiteman, David C.4 aut
700	1	a Olsson, Håkanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hol
700	1	a Puig, Susana4 aut
700	1	a Bianchi-Scarra, Giovanna4 aut
700	1	a Hansson, Johan4 aut
700	1	a Demenais, Florence4 aut
700	1	a Landi, Maria Teresa4 aut
700	1	a Debniak, Tadeusz4 aut
700	1	a Mackie, Rona4 aut
700	1	a Azizi, Esther4 aut
700	1	a Bressac-de Paillerets, Brigitte4 aut
700	1	a Goldstein, Alisa M.4 aut
700	1	a Kanetsky, Peter A.4 aut
700	1	a Gruis, Nelleke A.4 aut
700	1	a Elder, David E.4 aut
700	1	a Newton-Bishop, Julia A.4 aut
700	1	a Bishop, D. Timothy4 aut
700	1	a Iles, Mark M.4 aut
700	1	a Helsing, Per4 aut
700	1	a Amos, Christopher I.4 aut
700	1	a Wei, Qingyi4 aut
700	1	a Wang, Li-E4 aut
700	1	a Lee, Jeffrey E.4 aut
700	1	a Qureshi, Abrar A.4 aut
700	1	a Kefford, Richard F.4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Armstrong, Bruce K.4 aut
700	1	a Aitken, Joanne F.4 aut
700	1	a Han, Jiali4 aut
700	1	a Hopper, John L.4 aut
700	1	a Trent, Jeffrey M.4 aut
700	1	a Brown, Kevin M.4 aut
700	1	a Martin, Nicholas G.4 aut
700	1	a Mann, Graham J.4 aut
700	1	a Hayward, Nicholas K.4 aut
710	2	a Karolinska Institutetb Bröstcancer-genetik4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 43:11, s. 1114-1118q 43:11<1114-1118x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.958y FULLTEXT
856	4	u https://europepmc.org/articles/pmc3227560?pdf=render
856	4 8	u https://lup.lub.lu.se/record/2254280
856	4 8	u https://doi.org/10.1038/ng.958
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:123530970

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By the author/editor: MacGregor, Stuar ...; Montgomery, Gran ...; Liu, Jimmy Z.; Zhao, Zhen Zhen; Henders, Anjali ...; Stark, Mitchell; show more...; Schmid, Helen; Holland, Elizabe ...; Duffy, David L.; Zhang, Mingfeng; Painter, Jodie N ...; Nyholt, Dale R.; Maskiell, Judith ...; Jetann, Jodie; Ferguson, Megan; Cust, Anne E.; Jenkins, Mark A.; Whiteman, David ...; Olsson, Håkan; Puig, Susana; Bianchi-Scarra, ...; Hansson, Johan; Demenais, Floren ...; Landi, Maria Ter ...; Debniak, Tadeusz; Mackie, Rona; Azizi, Esther; Bressac-de Paill ...; Goldstein, Alisa ...; Kanetsky, Peter ...; Gruis, Nelleke A ...; Elder, David E.; Newton-Bishop, J ...; Bishop, D. Timot ...; Iles, Mark M.; Helsing, Per; Amos, Christophe ...; Wei, Qingyi; Wang, Li-E; Lee, Jeffrey E.; Qureshi, Abrar A ...; Kefford, Richard ...; Giles, Graham G.; Armstrong, Bruce ...; Aitken, Joanne F ...; Han, Jiali; Hopper, John L.; Trent, Jeffrey M ...; Brown, Kevin M.; Martin, Nicholas ...; Mann, Graham J.; Hayward, Nichola ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Nature Genetics

By the university: Lund University; Karolinska Institutet

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