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Sökning: WFRF:(Dunster C.) > Stored blood transf...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003630naa a2200433 4500
001oai:lup.lub.lu.se:6633b78e-bc58-4078-9a3b-b2b7731b9ad0
003SwePub
008160401s2013 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/39159402 URI
0247 a https://doi.org/10.1111/vox.120322 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Fung, Y.L.4 aut
2451 0a Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage.
264 c 2013-03-05
264 1b Wiley,c 2013
520 a BACKGROUND AND OBJECTIVES: Transfusion of blood products in particular older products is associated with patient morbidity. Previously, we demonstrated a higher incidence of acute lung injury in lipopolysaccharide-treated sheep transfused with stored blood products. As transfusion following haemorrhage is more common, we aimed to determine whether a 'first hit' of isolated haemorrhage would precipitate similar detrimental effects following transfusion and also disrupt haemostasis. MATERIALS AND METHODS: Anaesthetized sheep had 33% of their total blood volume collected into Leukotrap bags (Pall Medical), which were processed into packed red blood cells and cross-matched for transfusion into other sheep. After 30 mins, the sheep were resuscitated with either: fresh (<5 days old) or stored (35-42 days old) ovine blood followed by 4% albumin to replacement volume, albumin alone or normal saline alone and monitored for 4 h. RESULTS: The first hit of haemorrhage precipitated substantial decreases in mean arterial pressure however haemostasis was preserved. Transfusion of stored ovine blood induced (1) transient pulmonary arterial hypertension but no oedema and (2) reduced fibrinogen levels more than fresh blood, but neither induced coagulopathy. Thus, transfusion of stored blood affected pulmonary function even in the absence of overt organ injury. CONCLUSION: The fact that stored blood transfusions: (1) did not induce acute lung injury in contrast to previous lipopolysaccharide-primed animal models identifies the 'first hit' as an important determinant of the severity of transfusion-mediated injury; (2) impaired pulmonary dynamics verifies the sensitivity and vulnerability of the pulmonary system to injury.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
7001 a Tung, Y.P.4 aut
7001 a Foley, S.R.4 aut
7001 a Simonova, G.4 aut
7001 a Thom, O4 aut
7001 a Staib, A4 aut
7001 a Collier, J4 aut
7001 a Dunster, K.R.4 aut
7001 a Solano, C4 aut
7001 a Shekar, K4 aut
7001 a Chew, Michelleu Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups4 aut0 (Swepub:lu)anes-mch
7001 a Fraser, J F4 aut
7102 a Anestesiologi och intensivvårdb Forskargrupper vid Lunds universitet4 org
7730 t Vox Sanguinisd : Wileyg 105:2, s. 150-158q 105:2<150-158x 1423-0410x 0042-9007
8564 u http://www.ncbi.nlm.nih.gov/pubmed/?term=23458181x freey FULLTEXT
8564 u http://dx.doi.org/10.1111/vox.12032y FULLTEXT
8564 8u https://lup.lub.lu.se/record/3915940
8564 8u https://doi.org/10.1111/vox.12032

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