Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort

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Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort

Hidalgo, N. F. (author)

Gharamti, A. A. (author)

Aznar, M. L. (author)

Almirante, B. (author)

Yasmin, M. (author)

Fortes, C. Q. (author)

Plesiat, P. (author)

Doco-Lecompte, T. (author)

Rizk, H. (author)

Wray, D. (author)

Lamas, C. (author)

Durante-Mangoni, E. (author)

Tattevin, P. (author)

Snygg-Martin, Ulrika, 1965 (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine

Hannan, M. M. (author)

Chu, V. H. (author)

Kanafani, Z. A. (author)

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(creator_code:org_t)

2020-04-10
2020
English.
In: Open Forum Infectious Diseases. - : Oxford University Press (OUP). - 2328-8957. ; 7:5

Related links:: https://academic.oup...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background. Beta-hemolytic streptococci (BHS) are an uncommon cause of infective endocarditis (IE). The aim of this study was to describe the clinical features and outcomes of patients with BHS IE in a large multinational cohort and compare them with patients with viridans streptococcal IE. Methods. The International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) is a large multinational database that recruited patients with IE prospectively using a standardized data set. Sixty-four sites in 28 countries reported patients prospectively using a standard case report form developed by ICE collaborators. Results. Among 1336 definite cases of streptococcal IE, 823 were caused by VGS and 147 by BHS. Patients with BHS IE had a lower prevalence of native valve (P < .005) and congenital heart disease predisposition (P = .002), but higher prevalence of implantable cardiac device predisposition (P < .005). Clinically, they were more likely to present acutely (P < .005) and with fever (P = .024). BHS IE was more likely to be complicated by stroke and other systemic emboli (P < .005). The overall in-hospital mortality of BHS IE was significantly higher than that of VGS IE (P = .001). In univariate analysis, variables associated with in-hospital mortality for BHS IE were age (odds ratio [OR], 1.044; P = .004), prosthetic valve IE (OR, 3.029; P = .022), congestive heart failure (OR, 2.513; P = .034), and stroke (OR, 3.198; P = .009). Conclusions. BHS IE is characterized by an acute presentation and higher rate of stroke, systemic emboli, and in-hospital mortality than VGS IE. Implantable cardiac devices as a predisposing factor were more often found in BHS IE compared with VGS IE.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Keyword

beta-hemolytic streptococci
cardiac devices
congestive heart failure
infective endocarditis
International Collaboration on Endocarditis
group-b streptococcus
international collaboration
clinical
presentation
disease
diagnosis
Immunology
Infectious Diseases
Microbiology

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor: Hidalgo, N. F.; Gharamti, A. A.; Aznar, M. L.; Almirante, B.; Yasmin, M.; Fortes, C. Q.; show more...; Plesiat, P.; Doco-Lecompte, T ...; Rizk, H.; Wray, D.; Lamas, C.; Durante-Mangoni, ...; Tattevin, P.; Snygg-Martin, Ul ...; Hannan, M. M.; Chu, V. H.; Kanafani, Z. A.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

Articles in the publication: Open Forum Infec ...

By the university: University of Gothenburg

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