WFRF:(Dyer M.)
Sökning: WFRF:(Dyer M.) > (2020-2022) > Role of the Neutral...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04621naa a2200673 4500 | |
| 001 | oai:gup.ub.gu.se/302538 | |
| 003 | SwePub | |
| 008 | 240528s2021 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:145896269 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3025382 URI |
| 024 | 7 | a https://doi.org/10.2337/db20-00962 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1458962692 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jersin, R. A.4 aut |
| 245 | 1 0 | a Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance |
| 264 | c 2021-01-06 | |
| 264 | 1 | b American Diabetes Association,c 2021 |
| 520 | a Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose expression of the small neutral amino acid transporter SLC7A10, also known as alanine-serine-cysteine transporter-1 (ASC-1), shows strong inverse correlates with visceral adiposity, insulin resistance, and adipocyte hypertrophy across multiple cohorts. Concordantly, loss of Slc7a10 function in zebrafish in vivo accelerates diet-induced body weight gain and adipocyte enlargement. Mechanistically, SLC7A10 inhibition in human and murine adipocytes decreases adipocyte serine uptake and total glutathione levels and promotes reactive oxygen species (ROS) generation. Conversely, SLC7A10 overexpression decreases ROS generation and increases mitochondrial respiratory capacity. RNA sequencing revealed consistent changes in gene expression between human adipocytes and zebrafish visceral adipose tissue following loss of SLC7A10, e.g., upregulation of SCD (lipid storage) and downregulation of CPT1A (lipid oxidation). Interestingly, ROS scavenger reduced lipid accumulation and attenuated the lipid-storing effect of SLC7A10 inhibition. These data uncover adipocyte SLC7A10 as a novel important regulator of adipocyte resilience to nutrient and oxidative stress, in part by enhancing glutathione levels and mitochondrial respiration, conducive to decreased ROS generation, lipid accumulation, adipocyte hypertrophy, insulin resistance, and type 2 diabetes. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a Endocrinology & Metabolism | |
| 700 | 1 | a Tallapragada, D. S. P.4 aut |
| 700 | 1 | a Madsen, A.4 aut |
| 700 | 1 | a Skartveit, L.4 aut |
| 700 | 1 | a Fjaere, E.4 aut |
| 700 | 1 | a McCann, A.4 aut |
| 700 | 1 | a Dyer, L.4 aut |
| 700 | 1 | a Willems, A.4 aut |
| 700 | 1 | a Bjune, J. I.4 aut |
| 700 | 1 | a Bjune, M. S.4 aut |
| 700 | 1 | a Vage, V.4 aut |
| 700 | 1 | a Nielsen, H. J.4 aut |
| 700 | 1 | a Thorsen, H. L.4 aut |
| 700 | 1 | a Nedrebo, B. G.4 aut |
| 700 | 1 | a Busch, C.4 aut |
| 700 | 1 | a Steen, V. M.4 aut |
| 700 | 1 | a Bluher, M.4 aut |
| 700 | 1 | a Jacobson, Peter,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xjacop |
| 700 | 1 | a Svensson, Per-Arne,d 1969u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xsvper |
| 700 | 1 | a Ferno, J.4 aut |
| 700 | 1 | a Ryden, M.u Karolinska Institutet4 aut |
| 700 | 1 | a Arner, P.4 aut |
| 700 | 1 | a Nygard, O.4 aut |
| 700 | 1 | a Claussnitzer, M.4 aut |
| 700 | 1 | a Ellingsen, S.4 aut |
| 700 | 1 | a Madsen, L.4 aut |
| 700 | 1 | a Sagen, J. V.4 aut |
| 700 | 1 | a Mellgren, G.4 aut |
| 700 | 1 | a Dankel, S. N.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
| 773 | 0 | t Diabetesd : American Diabetes Associationg 70:3, s. 680-695q 70:3<680-695x 0012-1797x 1939-327X |
| 856 | 4 | u https://bora.uib.no/bora-xmlui/bitstream/11250/2761061/3/Jersin_et_al_2021_Diabetes_SLC7A10.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/302538 |
| 856 | 4 8 | u https://doi.org/10.2337/db20-0096 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145896269 |
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- Jersin, R. A.
- Tallapragada, D. ...
- Madsen, A.
- Skartveit, L.
- Fjaere, E.
- McCann, A.
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- Dyer, L.
- Willems, A.
- Bjune, J. I.
- Bjune, M. S.
- Vage, V.
- Nielsen, H. J.
- Thorsen, H. L.
- Nedrebo, B. G.
- Busch, C.
- Steen, V. M.
- Bluher, M.
- Jacobson, Peter, ...
- Svensson, Per-Ar ...
- Ferno, J.
- Ryden, M.
- Arner, P.
- Nygard, O.
- Claussnitzer, M.
- Ellingsen, S.
- Madsen, L.
- Sagen, J. V.
- Mellgren, G.
- Dankel, S. N.
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