Experimental evaluation of the effect of filtration of diesel exhaust by biologic exposure indicators

The airway resistance, compliance of the respiratory system, transfer factor, and alveolar volume of 33 healthy rabbits were studied before and after exposure to diluted diesel exhaust generated in an experimental motor. Three diesel fuels and two particle traps were tested. Subsequent to the post-exposure lung function measurements, the animals were sacrificed and the lungs were processed for morphologic examination. The concentrations of particles, nitrogen dioxide, and formaldehyde were measured. The inflammatory airway changes were most pronounced in animals exposed to exhaust from standard fuel. Small changes were identified in animals exposed to exhaust filtered through the catalytic trap as well or exposed to unfiltered exhaust from fuels intended for densely built-up areas. Increase in compliance of the respiratory system was associated with the concentration of soot particles and formaldehyde. Compliance decreased significantly in animals exposed to exhaust from standard fuel filtered through the particle traps and increased almost significantly in animals exposed to unfiltered exhaust from the same fuel.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
soot particles
diesel particulates
formaldehyde
nitrogen dioxide
acute pulmonary function effects
static compliance
airway resistance

Dahlqvist, M (författare)
Sandstrom, T (författare)
Bergstrom, B (författare)
Ekholm, U (författare)
Lagerstrand, L (författare)
Figler, B (författare)
Nilsen, A (författare)
Bjermer, LeifLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)lung-lbj (författare)
Tronnes, T (författare)
Lungmedicin, allergologi och palliativ medicinSektion II (creator_code:org_t)

Ingår i:American Journal of Industrial Medicine: Wiley27:1, s. 91-1060271-35861097-0274

Av författaren/redakt...: Ulfvarson, U; Dahlqvist, M; Sandstrom, T; Bergstrom, B; Ekholm, U; Lagerstrand, L; visa fler...; Figler, B; Nilsen, A; Bjermer, Leif; Tronnes, T; visa färre...

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