Sökning: WFRF:(Engelborghs Sebastiaan) >
Neurogranin and tau...
Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke.
-
De Vos, Ann (författare)
-
Bjerke, Maria, 1977 (författare)
-
Brouns, Raf (författare)
-
visa fler...
-
De Roeck, Naomi (författare)
-
Jacobs, Dirk (författare)
-
Van den Abbeele, Lien (författare)
-
Guldolf, Kaat (författare)
-
- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Engelborghs, Sebastiaan (författare)
-
Vanmechelen, Eugeen (författare)
-
visa färre...
-
(creator_code:org_t)
- 2017-08-30
- 2017
- Engelska.
-
Ingår i: BMC neurology. - : Springer Science and Business Media LLC. - 1471-2377. ; 17:1
- Relaterad länk:
-
https://bmcneurol.bi...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- While neurogranin has no value as plasma biomarker for Alzheimer's disease, it may be a potential blood biomarker for traumatic brain injury. This evokes the question whether there are changes in neurogranin levels in blood in other conditions of brain injury, such as acute ischemic stroke (AIS).We therefore explored neurogranin in paired cerebrospinal fluid (CSF)/plasma samples of AIS patients (n=50) from a well-described prospective study. In parallel, we investigated another neuronal protein, i.e. tau, which has already been suggested as potential AIS biomarker in CSF and blood. ELISA as well as Single Molecule Array (Simoa) technology were used for the biochemical analyses. Statistical analyses included Shapiro-Wilk testing, Mann-Whitney analyses and Pearson's correlation analysis.In contrast to tau, of which high levels in both CSF and plasma were related to stroke characteristics like severity and long-term outcome, plasma neurogranin levels were only correlated with infarct volume. Likewise, CSF neurogranin levels were significantly higher in patients with an infarct volume>5mL than in patients with smaller infarct volumes. Finally, neurogranin and tau were significantly correlated in CSF, whereas a weaker relationship was observed in plasma.These findings indicate that although plasma and CSF neurogranin may reflect the volume of acute cerebral ischemia, this synaptic protein is less likely to be a potential AIS biomarker. Levels of tau correlated with severity and outcome of stroke in both plasma and CSF, in the present study as well as previous reports, confirming the potential of tau as an AIS biomarker.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
De Vos, Ann
-
Bjerke, Maria, 1 ...
-
Brouns, Raf
-
De Roeck, Naomi
-
Jacobs, Dirk
-
Van den Abbeele, ...
-
visa fler...
-
Guldolf, Kaat
-
Zetterberg, Henr ...
-
Blennow, Kaj, 19 ...
-
Engelborghs, Seb ...
-
Vanmechelen, Eug ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
BMC neurology
- Av lärosätet
-
Göteborgs universitet