WFRF:(Fagman Henrik 1975)
Search: WFRF:(Fagman Henrik 1975) > (2015-2019) > Revising the embryo...
- 6 of 9
- Previous record
- Next record
- To hitlist
Revising the embryonic origin of thyroid C cells in mice and humans
-
- Johansson, Ellen (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
-
- Andersson, Louise, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
-
- Örnros, Jessica (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
- show more...
- Dahlberg, Jakob, 1969 (author)
- Jansson, Svante, 1948 (author)
- Parrillo, Luca (author)
- Zoppoli, Pietro (author)
- Barila, Guillermo O (author)
- Altschuler, Daniel L (author)
- Padula, Daniela (author)
- Lickert, Heiko (author)
- Fagman, Henrik, 1975 (author)
- show less...
- (creator_code:org_t)
- The Company of Biologists, 2015
- 2015
- English.
- In: Development (Cambridge, England). - : The Company of Biologists. - 1477-9129 .- 0950-1991. ; 142:20, s. 3519-3528
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Current understanding infers a neural crest origin of thyroid C cells, the major source of calcitonin in mammals and ancestors to neuroendocrine thyroid tumors. The concept is primarily based on investigations in quail-chick chimeras involving fate-mapping of neural crest cells to the ultimobranchial glands that regulate Ca(2+) homeostasis in birds, reptiles, amphibians and fishes, but whether mammalian C cell development implicates a homologous ontogenetic trajectory has not been experimentally verified. With lineage tracing we now provide direct evidence that Sox17+ anterior endoderm is the only source of differentiated C cells and their progenitors in mice. In similarity with many gut endoderm derivatives embryonic C cells were found to co-express pioneer factors forkhead box (Fox) a1 and Foxa2 before neuroendocrine differentiation takes place. In the ultimobranchial body epithelium emerging from pharyngeal pouch endoderm in early organogenesis differential Foxa1/Foxa2 expression distinguished two spatially separated pools of C cell precursors with different growth properties. A similar expression pattern was recapitulated in medullary thyroid carcinoma cells in vivo consistent with a growth-promoting role of Foxa1. Contrasting embryonic precursor cells, C cell-derived tumor cells invading the stromal compartment down-regulated Foxa2 foregoing epithelial-mesenchymal transition designated by loss of E-cadherin; both Foxa2 and E-cadherin were re-expressed at metastatic sites. These findings revise mammalian C cell ontogeny, expand the neuroendocrine repertoire of endoderm, and redefine the boundaries of neural crest diversification. The data further underpin distinct functions of Foxa1 and Foxa2 in both embryonic and tumor development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Development (Cambridge, England) (Search for host publication in LIBRIS)
To the university's database
- 6 of 9
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Johansson, Ellen
- Andersson, Louis ...
- Örnros, Jessica
- Carlsson, Theres ...
- Ingeson-Carlsson ...
- Liang, Shawn, 19 ...
- show more...
- Dahlberg, Jakob, ...
- Jansson, Svante, ...
- Parrillo, Luca
- Zoppoli, Pietro
- Barila, Guillerm ...
- Altschuler, Dani ...
- Padula, Daniela
- Lickert, Heiko
- Fagman, Henrik, ...
- Nilsson, Mikael
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Surgery
- Articles in the publication
- Development (Cam ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
