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External Validation...
External Validation of the Ovarian-Adnexal Reporting and Data System (O-RADS) Lexicon and the International Ovarian Tumor Analysis 2-Step Strategy to Stratify Ovarian Tumors Into O-RADS Risk Groups
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- Timmerman, Stefan (författare)
- Catholic University of Leuven,University Hospitals Leuven
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- Valentin, Lil (författare)
- Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital
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- Ceusters, Jolien (författare)
- Leuven Cancer Institute
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- Testa, Antonia C (författare)
- Policlinico Universitario Agostino Gemelli
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- Landolfo, Chiara (författare)
- Imperial College Healthcare NHS Trust
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- Sladkevicius, Povilas (författare)
- Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital
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- Van Holsbeke, Caroline (författare)
- Hospital Oost-Limburg
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- Domali, Ekaterini (författare)
- National and Kapodistrian University of Athens
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- Fruscio, Robert (författare)
- University of Milano-Bicocca
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- Epstein, Elisabeth (författare)
- Karolinska Institutet,Karolinska Institute
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- Franchi, Dorella (författare)
- European Institute of Oncology
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- Kudla, Marek J (författare)
- Medical University of Silesia
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- Chiappa, Valentina (författare)
- Istituto Nazionale dei Tumori
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- Alcazar, Juan L (författare)
- University Clinic of Navarra
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- Leone, Francesco P G (författare)
- University of Milan
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- Buonomo, Francesca (författare)
- Burlo Garofolo Pediatric Institute
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- Coccia, Maria Elisabetta (författare)
- University of Florence
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- Guerriero, Stefano (författare)
- University of Cagliari
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- Deo, Nandita (författare)
- Whipps Cross University Hospital
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- Jokubkiene, Ligita (författare)
- Lund University,Lunds universitet,Urogynekologi och reproduktionsfarmakologi,Forskargrupper vid Lunds universitet,Urogynaecology and Reproductive Pharmacology,Lund University Research Groups,Skåne University Hospital
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- Kaijser, Jeroen (författare)
- Ikazia Hospital
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- Scambia, Giovanni (författare)
- Policlinico Universitario Agostino Gemelli
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- Andreotti, Rochelle (författare)
- Vanderbilt University Medical Center
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- Timmerman, Dirk (författare)
- University Hospitals Leuven,Catholic University of Leuven
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- Bourne, Tom (författare)
- Catholic University of Leuven,Imperial College London
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- Van Calster, Ben (författare)
- Leiden University Medical Centre,Catholic University of Leuven
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- Froyman, Wouter (författare)
- University Hospitals Leuven,Catholic University of Leuven
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(creator_code:org_t)
- American Medical Association (AMA), 2023
- 2023
- Engelska.
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Ingår i: JAMA Oncology. - : American Medical Association (AMA). - 2374-2437 .- 2374-2445. ; 9:2, s. 225-233
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- IMPORTANCE: Correct diagnosis of ovarian cancer results in better prognosis. Adnexal lesions can be stratified into the Ovarian-Adnexal Reporting and Data System (O-RADS) risk of malignancy categories with either the O-RADS lexicon, proposed by the American College of Radiology, or the International Ovarian Tumor Analysis (IOTA) 2-step strategy.OBJECTIVE: To investigate the diagnostic performance of the O-RADS lexicon and the IOTA 2-step strategy.DESIGN, SETTING, AND PARTICIPANTS: Retrospective external diagnostic validation study based on interim data of IOTA5, a prospective international multicenter cohort study, in 36 oncology referral centers or other types of centers. A total of 8519 consecutive adult patients presenting with an adnexal mass between January 1, 2012, and March 1, 2015, and treated either with surgery or conservatively were included in this diagnostic study. Twenty-five patients were excluded for withdrawal of consent, 2777 were excluded from 19 centers that did not meet predefined data quality criteria, and 812 were excluded because they were already in follow-up at recruitment. The analysis included 4905 patients with a newly detected adnexal mass in 17 centers that met predefined data quality criteria. Data were analyzed from January 31 to March 1, 2022.EXPOSURES: Stratification into O-RADS categories (malignancy risk <1%, 1% to <10%, 10% to <50%, and ≥50%). For the IOTA 2-step strategy, the stratification is based on the individual risk of malignancy calculated with the IOTA 2-step strategy.MAIN OUTCOMES AND MEASURES: Observed prevalence of malignancy in each O-RADS risk category, as well as sensitivity and specificity. The reference standard was the status of the tumor at inclusion, determined by histology or clinical and ultrasonographic follow-up for 1 year. Multiple imputation was used for uncertain outcomes owing to inconclusive follow-up information.RESULTS: Median age of the 4905 patients was 48 years (IQR, 36-62 years). Data on race and ethnicity were not collected. A total of 3441 tumors (70%) were benign, 978 (20%) were malignant, and 486 (10%) had uncertain classification. Using the O-RADS lexicon resulted in 1.1% (24 of 2196) observed prevalence of malignancy in O-RADS 2, 4% (34 of 857) in O-RADS 3, 27% (246 of 904) in O-RADS 4, and 78% (732 of 939) in O-RADS 5; the corresponding results for the IOTA 2-step strategy were 0.9% (18 of 1984), 4% (58 of 1304), 30% (206 of 690), and 82% (756 of 927). At the 10% risk threshold (O-RADS 4-5), the O-RADS lexicon had 92% sensitivity (95% CI, 87%-96%) and 80% specificity (95% CI, 74%-85%), and the IOTA 2-step strategy had 91% sensitivity (95% CI, 84%-95%) and 85% specificity (95% CI, 80%-88%).CONCLUSIONS AND RELEVANCE: The findings of this external diagnostic validation study suggest that both the O-RADS lexicon and the IOTA 2-step strategy can be used to stratify patients into risk groups. However, the observed malignancy rate in O-RADS 2 was not clearly below 1%.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Timmerman, Stefa ...
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Valentin, Lil
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Ceusters, Jolien
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Testa, Antonia C
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Landolfo, Chiara
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Sladkevicius, Po ...
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visa fler...
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Van Holsbeke, Ca ...
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Domali, Ekaterin ...
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Fruscio, Robert
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Epstein, Elisabe ...
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Franchi, Dorella
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Kudla, Marek J
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Chiappa, Valenti ...
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Alcazar, Juan L
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Leone, Francesco ...
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Buonomo, Frances ...
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Coccia, Maria El ...
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Guerriero, Stefa ...
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Deo, Nandita
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Jokubkiene, Ligi ...
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Kaijser, Jeroen
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Scambia, Giovann ...
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Andreotti, Roche ...
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Timmerman, Dirk
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Bourne, Tom
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Van Calster, Ben
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Froyman, Wouter
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
- Artiklar i publikationen
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JAMA Oncology
- Av lärosätet
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Lunds universitet
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Karolinska Institutet