Sökning: WFRF:(Frohnert Brigitte I) >
Refining the Defini...
Refining the Definition of Stage 1 Type 1 Diabetes : An Ontology-Driven Analysis of the Heterogeneity of Multiple Islet Autoimmunity
-
- Frohnert, Brigitte I. (författare)
- University of Colorado
-
- Ghalwash, Mohamed (författare)
- Ain Shams University,IBM Thomas J. Watson Research Center
-
- Li, Ying (författare)
- IBM Thomas J. Watson Research Center
-
visa fler...
-
- Ng, Kenney (författare)
- IBM Thomas J. Watson Research Center
-
- Dunne, Jessica L. (författare)
- Juvenile Diabetes Research Foundation
-
- Lundgren, Markus (författare)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad
-
- Hagopian, William (författare)
- Pacific Northwest Research Institute
-
- Lou, Olivia (författare)
- Juvenile Diabetes Research Foundation
-
- Winkler, Christiane (författare)
- Helmholtz Zentrum München
-
- Toppari, Jorma (författare)
- Turku University Hospital
-
- Veijola, Riitta (författare)
- University of Oulu
-
- Anand, Vibha (författare)
- IBM Thomas J. Watson Research Center
-
visa färre...
-
(creator_code:org_t)
-
- 2023-03-02
- 2023
- Engelska 9 s.
-
Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 46:10, s. 1753-1761
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.2...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE To estimate the risk of progression to stage 3 type 1 diabetes based on varying definitions of multiple islet autoantibody positivity (mIA). RESEARCH DESIGN AND METHODS Type 1 Diabetes Intelligence (T1DI) is a combined prospective data set of children from Finland, Germany, Sweden, and the U.S. who have an increased genetic risk for type 1 diabetes. Analysis included 16,709 infants-toddlers enrolled by age 2.5 years and comparison between groups using Kaplan-Meier survival analysis. RESULTS Of 865 (5%) children with mIA, 537 (62%) progressed to type 1 diabetes. The 15-year cumulative incidence of diabetes varied from the most stringent definition (mIA/ Persistent/2: two or more islet autoantibodies positive at the same visit with two or more antibodies persistent at next visit; 88% [95% CI 85–92%]) to the least stringent (mIA/Any: positivity for two islet autoantibodies without co-occurring positivity or persistence; 18% [5–40%]). Progression in mIA/Persistent/2 was significantly higher than all other groups (P < 0.0001). Intermediate stringency definitions showed intermediate risk and were significantly different than mIA/Any (P < 0.05); however, differences waned over the 2-year follow-up among those who did not subsequently reach higher stringency. Among mIA/Persistent/2 individuals with three autoantibodies, loss of one autoantibody by the 2-year follow-up was associated with accelerated progression. Age was significantly associated with time from seroconversion to mIA/ Persistent/2 status and mIA to stage 3 type 1 diabetes. CONCLUSIONS The 15-year risk of progression to type 1 diabetes risk varies markedly from 18 to 88% based on the stringency of mIA definition. While initial categorization identifies highest-risk individuals, short-term follow-up over 2 years may help stratify evolving risk, especially for those with less stringent definitions of mIA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Frohnert, Brigit ...
-
Ghalwash, Mohame ...
-
Li, Ying
-
Ng, Kenney
-
Dunne, Jessica L ...
-
Lundgren, Markus
-
visa fler...
-
Hagopian, Willia ...
-
Lou, Olivia
-
Winkler, Christi ...
-
Toppari, Jorma
-
Veijola, Riitta
-
Anand, Vibha
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Diabetes Care
- Av lärosätet
-
Lunds universitet