Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations

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MARC

Fältnamn	Indikatorer	Metadata
000		06192naa a2201177 4500
001		oai:lup.lub.lu.se:9d8b966d-69bf-40d7-a746-5f32ac5c71e7
003		SwePub
008		160401s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/44880502 URI
024	7	a https://doi.org/10.1093/hmg/ddt6262 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Yoneyama, Sachiko4 aut
245	1 0	a Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations
264		c 2013-12-17
264	1	b Oxford University Press (OUP),c 2014
520		a Waist circumference (WC) and waist-to-hip ratio (WHR) are surrogate measures of central adiposity that are associated with adverse cardiovascular events, type 2 diabetes and cancer independent of body mass index (BMI). WC and WHR are highly heritable with multiple susceptibility loci identified to date. We assessed the association between SNPs and BMI-adjusted WC and WHR and unadjusted WC in up to 57 412 individuals of European descent from 22 cohorts collaborating with the NHLBIs Candidate Gene Association Resource (CARe) project. The study population consisted of women and men aged 2080 years. Study participants were genotyped using the ITMAT/Broad/CARE array, which includes 50 000 cosmopolitan tagged SNPs across 2100 cardiovascular-related genes. Each trait was modeled as a function of age, study site and principal components to control for population stratification, and we conducted a fixed-effects meta-analysis. No new loci for WC were observed. For WHR analyses, three novel loci were significantly associated (P 2.4 10(6)). Previously unreported rs2811337-G near TMCC1 was associated with increased WHR ( SE, 0.048 0.008, P 7.7 10(9)) as was rs7302703-G in HOXC10 ( 0.044 0.008, P 2.9 10(7)) and rs936108-C in PEMT ( 0.035 0.007, P 1.9 10(6)). Sex-stratified analyses revealed two additional novel signals among females only, rs12076073-A in SHC1 ( 0.10 0.02, P 1.9 10(6)) and rs1037575-A in ATBDB4 ( 0.046 0.01, P 2.2 10(6)), supporting an already established sexual dimorphism of central adiposity-related genetic variants. Functional analysis using ENCODE and eQTL databases revealed that several of these loci are in regulatory regions or regions with differential expression in adipose tissue.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Guo, Yiran4 aut
700	1	a Lanktree, Matthew B.4 aut
700	1	a Barnes, Michael R.4 aut
700	1	a Elbers, Clara C.4 aut
700	1	a Karczewski, Konrad J.4 aut
700	1	a Padmanabhan, Sandosh4 aut
700	1	a Bauer, Florianne4 aut
700	1	a Baumert, Jens4 aut
700	1	a Beitelshees, Amber4 aut
700	1	a Berenson, Gerald S.4 aut
700	1	a Boer, Jolanda M. A.4 aut
700	1	a Burke, Gregory4 aut
700	1	a Cade, Brian4 aut
700	1	a Chen, Wei4 aut
700	1	a Cooper-Dehoff, Rhonda M.4 aut
700	1	a Gaunt, Tom R.4 aut
700	1	a Gieger, Christian4 aut
700	1	a Gong, Yan4 aut
700	1	a Gorski, Mathias4 aut
700	1	a Heard-Costa, Nancy4 aut
700	1	a Johnson, Toby4 aut
700	1	a Lamonte, Michael J.4 aut
700	1	a Mcdonough, Caitrin4 aut
700	1	a Monda, Keri L.4 aut
700	1	a Onland-Moret, N. Charlotte4 aut
700	1	a Nelson, Christopher P.4 aut
700	1	a O'Connell, Jeffrey R.4 aut
700	1	a Ordovas, Jose4 aut
700	1	a Peter, Inga4 aut
700	1	a Peters, Annette4 aut
700	1	a Shaffer, Jonathan4 aut
700	1	a Shen, Haiqinq4 aut
700	1	a Smith, Erin4 aut
700	1	a Speilotes, Liz4 aut
700	1	a Thomas, Fridtjof4 aut
700	1	a Thorand, Barbara4 aut
700	1	a Verschuren, W. M. Monique4 aut
700	1	a Anand, Sonia S.4 aut
700	1	a Dominiczak, Anna4 aut
700	1	a Davidson, Karina W.4 aut
700	1	a Hegele, Robert A.4 aut
700	1	a Heid, Iris4 aut
700	1	a Hofker, Marten H.4 aut
700	1	a Huggins, Gordon S.4 aut
700	1	a Illig, Thomas4 aut
700	1	a Johnson, Julie A.4 aut
700	1	a Kirkland, Susan4 aut
700	1	a Koenig, Wolfgang4 aut
700	1	a Langaee, Taimour Y.4 aut
700	1	a Mccaffery, Jeanne4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Mitchell, Braxton D.4 aut
700	1	a Munroe, Patricia4 aut
700	1	a Murray, Sarah S.4 aut
700	1	a Papanicolaou, George4 aut
700	1	a Redline, Susan4 aut
700	1	a Reilly, Muredach4 aut
700	1	a Samani, Nilesh J.4 aut
700	1	a Schork, Nicholas J.4 aut
700	1	a Van der Schouw, Yvonne T.4 aut
700	1	a Shimbo, Daichi4 aut
700	1	a Shuldiner, Alan R.4 aut
700	1	a Tobin, Martin D.4 aut
700	1	a Wijmenga, Cisca4 aut
700	1	a Yusuf, Salim4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Lange, Leslie A.4 aut
700	1	a Demerath, Ellen W.4 aut
700	1	a Fox, Caroline S.4 aut
700	1	a North, Kari E.4 aut
700	1	a Reiner, Alex P.4 aut
700	1	a Keating, Brendan4 aut
700	1	a Taylor, Kira C.4 aut
710	2	a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org
773	0	t Human Molecular Geneticsd : Oxford University Press (OUP)g 23:9, s. 2498-2510q 23:9<2498-2510x 0964-6906x 1460-2083
856	4	u http://dx.doi.org/10.1093/hmg/ddt626y FULLTEXT
856	4	u https://academic.oup.com/hmg/article-pdf/23/9/2498/14142890/ddt626.pdf
856	4 8	u https://lup.lub.lu.se/record/4488050
856	4 8	u https://doi.org/10.1093/hmg/ddt626

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By the author/editor: Yoneyama, Sachik ...; Guo, Yiran; Lanktree, Matthe ...; Barnes, Michael ...; Elbers, Clara C.; Karczewski, Konr ...; show more...; Padmanabhan, San ...; Bauer, Florianne; Baumert, Jens; Beitelshees, Amb ...; Berenson, Gerald ...; Boer, Jolanda M. ...; Burke, Gregory; Cade, Brian; Chen, Wei; Cooper-Dehoff, R ...; Gaunt, Tom R.; Gieger, Christia ...; Gong, Yan; Gorski, Mathias; Heard-Costa, Nan ...; Johnson, Toby; Lamonte, Michael ...; Mcdonough, Caitr ...; Monda, Keri L.; Onland-Moret, N. ...; Nelson, Christop ...; O'Connell, Jeffr ...; Ordovas, Jose; Peter, Inga; Peters, Annette; Shaffer, Jonatha ...; Shen, Haiqinq; Smith, Erin; Speilotes, Liz; Thomas, Fridtjof; Thorand, Barbara; Verschuren, W. M ...; Anand, Sonia S.; Dominiczak, Anna; Davidson, Karina ...; Hegele, Robert A ...; Heid, Iris; Hofker, Marten H ...; Huggins, Gordon ...; Illig, Thomas; Johnson, Julie A ...; Kirkland, Susan; Koenig, Wolfgang; Langaee, Taimour ...; Mccaffery, Jeann ...; Melander, Olle; Mitchell, Braxto ...; Munroe, Patricia; Murray, Sarah S.; Papanicolaou, Ge ...; Redline, Susan; Reilly, Muredach; Samani, Nilesh J ...; Schork, Nicholas ...; Van der Schouw, ...; Shimbo, Daichi; Shuldiner, Alan ...; Tobin, Martin D.; Wijmenga, Cisca; Yusuf, Salim; Hakonarson, Hako ...; Lange, Leslie A.; Demerath, Ellen ...; Fox, Caroline S.; North, Kari E.; Reiner, Alex P.; Keating, Brendan; Taylor, Kira C.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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By the university: Lund University

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