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  • Feng, XiaoshuangGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)

Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Oxford University Press,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-214407
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214407URI
  • https://doi.org/10.1093/jnci/djad071DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with a smoking-based risk model (PLCOm2012) and a commercially available autoantibody biomarker test.METHODS: We designed a case-control study nested in 6 prospective cohorts, including 624 lung cancer participants who donated blood samples at most 3 years prior to lung cancer diagnosis and 624 smoking-matched cancer free participants who were assayed for 302 proteins. We used 470 case-control pairs from 4 cohorts to select proteins and train a protein-based risk model. We subsequently used 154 case-control pairs from 2 cohorts to compare the risk-discriminatory performance of the protein-based model with that of the Early Cancer Detection Test (EarlyCDT)-Lung and the PLCOm2012 model using receiver operating characteristics analysis and by estimating models' sensitivity. All tests were 2-sided.RESULTS: The area under the curve for the protein-based risk model in the validation sample was 0.75 (95% confidence interval [CI] = 0.70 to 0.81) compared with 0.64 (95% CI = 0.57 to 0.70) for the PLCOm2012 model (Pdifference = .001). The EarlyCDT-Lung had a sensitivity of 14% (95% CI = 8.2% to 19%) and a specificity of 86% (95% CI = 81% to 92%) for incident lung cancer. At the same specificity of 86%, the sensitivity for the protein-based risk model was estimated at 49% (95% CI = 41% to 57%) and 30% (95% CI = 23% to 37%) for the PLCOm2012 model.CONCLUSION: Circulating proteins showed promise in predicting incident lung cancer and outperformed a standard risk prediction model and the commercialized EarlyCDT-Lung.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wu, Wendy Yi-YingUmeå universitet,Onkologi(Swepub:umu)weyi0002 (författare)
  • Onwuka, Justina UcheojorGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Haider, ZahraUmeå universitet,Onkologi(Swepub:umu)zaha0008 (författare)
  • Alcala, KarineGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Smith-Byrne, KarlCancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom (författare)
  • Zahed, HanaGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Guida, FlorenceEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Wang, RenweiDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States (författare)
  • Bassett, Julie K.Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia (författare)
  • Stevens, VictoriaRollins School of Public Health, Emory University, GA, Atlanta, United States (författare)
  • Wang, YingAmerican Cancer Society, GA, Atlanta, United States (författare)
  • Weinstein, StephanieMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States (författare)
  • Freedman, Neal D.Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States (författare)
  • Chen, ChuProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
  • Tinker, LesleyWomen's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
  • Nøst, Therese HaugdahlDepartment of Community Medicine, University of Tromsø, Arctic University of Norway, Tromsø, Norway (författare)
  • Koh, Woon-PuayHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore (författare)
  • Muller, DavidDivision of Genetic Medicine, Imperial College London School of Public Health, London, United Kingdom (författare)
  • Colorado-Yohar, Sandra M.Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia (författare)
  • Tumino, RosarioHyblean Association for Epidemiological Research, Ragusa, Italy (författare)
  • Hung, Rayjean J.Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada (författare)
  • Amos, Christopher I.Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States (författare)
  • Lin, XihongDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Statistics, Harvard University, MA, Cambridge, United States (författare)
  • Zhang, XuehongBrigham and Women's Hospital, Harvard Medical School, MA, Boston, United States (författare)
  • Arslan, Alan A.Department of Population Health, New York University School of Medicine, New York, NY, USA (författare)
  • Sánchez, Maria-JoseCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ib, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain (författare)
  • Sørgjerd, Elin PettersenHUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway (författare)
  • Severi, GianlucaInserm, Université Paris-Saclay, Villejuif, France (författare)
  • Hveem, KristianHUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway (författare)
  • Brennan, PaulGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Langhammer, ArnulfHUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway (författare)
  • Milne, Roger L.Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (författare)
  • Yuan, Jian-MinDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States (författare)
  • Melin, Beatrice S.Umeå universitet,Onkologi(Swepub:umu)bema0010 (författare)
  • Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025 (författare)
  • Robbins, Hilary A.Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Johansson, MattiasGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, FranceOnkologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of the National Cancer Institute: Oxford University Press115:9, s. 1050-10590027-88741460-2105

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