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FältnamnIndikatorerMetadata
00008581naa a2200733 4500
001oai:DiVA.org:his-20648
003SwePub
008211014s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:147800399
009oai:DiVA.org:liu-180368
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-206482 URI
0247 a https://doi.org/10.1080/15592294.2021.19825102 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1478003992 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1803682 URI
040 a (SwePub)hisd (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Badam, Tejaswiu Linköpings universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Bioinformatics Department of Physics, Chemistry and Biology, Linköping University, Sweden,Translationell bioinformatik, Translational Bioinformatics,Bioinformatik,Tekniska fakulteten,Skovde Univ, Sweden4 aut0 (Swepub:liu)tejba58
2451 0a CD4(+) T-cell DNA methylation changes during pregnancy significantly correlate with disease-associated methylation changes in autoimmune diseases
264 c 2021-10-04
264 1b Taylor & Francis Group,c 2022
338 a electronic2 rdacarrier
500 a CC BY 4.0Contact Sandra Hellberg Email iconsandra.hellberg@liu.sePublished online: 04 Oct 2021Copyright © 2022 Informa UK Limited This work was supported by the Swedish Foundation for Strategic Research (SB16-0011), Swedish Research Council (K2013-61X-22310-01-4, 2015-030807, 2018-02776) and Lions research grant (Liu-2012-01948).
500 a Funding Agencies|Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research [SB16-0011]; Swedish Research CouncilSwedish Research CouncilEuropean Commission [K2013-61X-22310-01-4, 2015-030807, 2018-02776]; Lions research grant [Liu-2012-01948]
520 a Epigenetics may play a central, yet unexplored, role in the profound changes that the maternal immune system undergoes during pregnancy and could be involved in the pregnancy-induced modulation of several autoimmune diseases. We investigated changes in the methylome in isolated circulating CD4(+) T-cells in non-pregnant and pregnant women, during the 1(st) and 2(nd) trimester, using the Illumina Infinium Human Methylation 450K array, and explored how these changes were related to autoimmune diseases that are known to be affected during pregnancy. Pregnancy was associated with several hundreds of methylation differences, particularly during the 2(nd) trimester. A network-based modular approach identified several genes, e.g., CD28, FYN, VAV1 and pathways related to T-cell signalling and activation, highlighting T-cell regulation as a central component of the observed methylation alterations. The identified pregnancy module was significantly enriched for disease-associated methylation changes related to multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. A negative correlation between pregnancy-associated methylation changes and disease-associated changes was found for multiple sclerosis and rheumatoid arthritis, diseases that are known to improve during pregnancy whereas a positive correlation was found for systemic lupus erythematosus, a disease that instead worsens during pregnancy. Thus, the directionality of the observed changes is in line with the previously observed effect of pregnancy on disease activity. Our systems medicine approach supports the importance of the methylome in immune regulation of T-cells during pregnancy. Our findings highlight the relevance of using pregnancy as a model for understanding and identifying disease-related mechanisms involved in the modulation of autoimmune diseases.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
653 a Pregnancy
653 a epigenetics
653 a methylation
653 a CD4(+) T cells
653 a module
653 a rheumatoid arthritis
653 a multiple sclerosis
653 a systemic lupus erythematosus
653 a Bioinformatik
653 a Bioinformatics
7001 a Hellberg, Sandrau Linköpings universitet,Bioinformatik,Tekniska fakulteten4 aut0 (Swepub:liu)sanhe13
7001 a Bhai Mehta, Ratneshu Linköpings universitet,Karolinska Institutet,Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Sweden,Avdelningen för inflammation och infektion,Medicinska fakulteten4 aut0 (Swepub:liu)ratme61
7001 a Lechner-Scott, Jeannetteu School of Medicine and Public Health, University of Newcastle, Callaghan, Australia ; Centre for Brain and Mental Health, Hunter Medical Research Institute, New Lambton Heights, Australia ; Department of Neurology, John Hunter Hospital, New Lambton Heights, Australia,Univ Newcastle, Australia; Hunter Med Res Inst, Australia; John Hunter Hosp, Australia4 aut
7001 a Lea, Rodney A.u School of Medicine and Public Health, University of Newcastle, Callaghan, Australia ; Centre for Brain and Mental Health, Hunter Medical Research Institute, New Lambton Heights, Australia ; Institute of Health and Biomedical Innovations, Genomics Research Centre, Queensland University of Technology, Kelvin Grove, Australia,Univ Newcastle, Australia; Hunter Med Res Inst, Australia; Queensland Univ Technol, Australia4 aut
7001 a Tost, Jorgu Laboratory of Epigenetics and Environment, Centre National De Recherche En Génomique Humaine, CEA-Institut De Biologie Francois Jacob, Evry, France,CEA Inst Biol Francois Jacob, France4 aut
7001 a Mariette, Xavieru Université Paris-Saclay, AP-HP-Université Paris-Saclay, Hôpital Bicêtre, Institut National de la Santé et de la Recherche Médicale (Inserm) U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, France,Univ Paris Saclay, France4 aut
7001 a Svensson-Arvelund, Judit,d 1982-u Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten4 aut0 (Swepub:liu)judsv82
7001 a Nestor, Colmu Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten4 aut0 (Swepub:liu)colne37
7001 a Benson, Mikaelu Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus4 aut0 (Swepub:liu)mikbe05
7001 a Berg, Göranu Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US4 aut0 (Swepub:liu)gorbe09
7001 a Jenmalm, Mariau Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten4 aut0 (Swepub:liu)marje18
7001 a Gustafsson, Mikau Linköpings universitet,Bioinformatik,Tekniska fakulteten4 aut0 (Swepub:liu)mikgu75
7001 a Ernerudh, Janu Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin4 aut0 (Swepub:liu)janer15
7102 a Högskolan i Skövdeb Institutionen för biovetenskap4 org
7730 t Epigeneticsd : Taylor & Francis Groupg 17:9, s. 1040-1055q 17:9<1040-1055x 1559-2294x 1559-2308
8564 u https://doi.org/10.1080/15592294.2021.1982510y Fulltext
8564 u https://his.diva-portal.org/smash/get/diva2:1602961/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.tandfonline.com/doi/pdf/10.1080/15592294.2021.1982510?needAccess=true
8564 u https://liu.diva-portal.org/smash/get/diva2:1603903/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20648
8564 8u https://doi.org/10.1080/15592294.2021.1982510
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:147800399
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-180368

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