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WFRF:(Hagen Chris)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004379naa a2200469 4500
001oai:lup.lub.lu.se:3fa26551-91f8-417d-8cf6-99c30beb11e4
003SwePub
008160401s2011 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/18766272 URI
0247 a https://doi.org/10.1136/ard.2010.1377782 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Flossmann, Oliver4 aut
2451 0a Long-term patient survival in ANCA-associated vasculitis
264 c 2010-11-24
264 1b BMJ,c 2011
520 a Background Wegener's granulomatosis and microscopic polyangiitis are antineutrophil cytoplasm antibodies (ANCA)-associated vasculitides with significant morbidity and mortality. The long-term survival of patients with ANCA associated vasculitis treated with current regimens is uncertain. Objective To describe the long-term patient survival and possible prognostic factors at presentation in an international, multicentre, prospectively recruited representative patient cohort who were treated according to strictly defined protocols at presentation and included the full spectrum of ANCA-associated vasculitis disease. Methods Outcome data were collected for 535 patients who had been recruited at the time of diagnosis to four randomised controlled trials between 1995 and 2002. Trial eligibility was defined by disease severity and extent, covered the spectrum of severity of ANCA-associated vasculitis and used consistent diagnostic criteria. Demographic, clinical and laboratory parameters at trial entry were tested as potential prognostic factors in multivariable models. Results The median duration of follow-up was 5.2 years and 133 (25%) deaths were recorded. Compared with an age-and sex-matched general population there was a mortality ratio of 2.6 (95% CI 2.2 to 3.1). Main causes of death within the first year were infection (48%) and active vasculitis (19%). After the first year the major causes of death were cardiovascular disease (26%), malignancy (22%) and infection (20%). Multivariable analysis showed an estimated glomerular filtration rate <15 ml/min, advancing age, higher Birmingham Vasculitis Activity Score, lower haemoglobin and higher white cell count were significant negative prognostic factors for patient survival. Conclusion Patients with ANCA-associated vasculitis treated with conventional regimens are at increased risk of death compared with an age-and sex-matched population.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Berden, Annelies4 aut
7001 a de Groot, Kirsten4 aut
7001 a Hagen, Chris4 aut
7001 a Harper, Lorraine4 aut
7001 a Heijl, Carolineu Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-clh
7001 a Höglund, Peteru Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kfar-pho
7001 a Jayne, David4 aut
7001 a Luqmani, Raashid4 aut
7001 a Mahr, Alfred4 aut
7001 a Mukhtyar, Chetan4 aut
7001 a Pusey, Charles4 aut
7001 a Rasmussen, Niels4 aut
7001 a Stegeman, Coen4 aut
7001 a Walsh, Michael4 aut
7001 a Westman, Kerstinu Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)njur-kwe
7102 a Njurmedicinb Sektion II4 org
7730 t Annals of the Rheumatic Diseasesd : BMJg 70:3, s. 488-494q 70:3<488-494x 1468-2060x 0003-4967
8564 u http://dx.doi.org/10.1136/ard.2010.137778y FULLTEXT
8564 8u https://lup.lub.lu.se/record/1876627
8564 8u https://doi.org/10.1136/ard.2010.137778

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