Sökning: WFRF:(Hegardt Cecilia) > (2005-2009) > Different cell cycl...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04100naa a2200361 4500 | |
001 | oai:lup.lub.lu.se:3485bb93-05ae-4570-9523-e00b49cb3c0c | |
003 | SwePub | |
008 | 160404s2008 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/11545882 URI |
024 | 7 | a https://doi.org/10.1097/CAD.0b013e3282f7f5182 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Myhre, Louiseu Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science4 aut0 (Swepub:lu)zoof-lmy |
245 | 1 0 | a Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines. |
264 | 1 | c 2008 |
520 | a Polyamine analogues are presently undergoing clinical evaluation in the treatment of cancer. To better understand under what circumstances treatment with a polyamine analogue will yield beneficial results, we have investigated the effect of N,N-diethylnorspermine (DENSPM) on cell cycle kinetics of the human breast cancer cell lines SK-BR-3, MCF-7, HCC1937, and L56Br-C1. A bromodeoxyuridine-DNA flow cytometry method was used to evaluate the treatment with 10 micromol/l DENSPM on cell cycle kinetics. A correlation between polyamine pool size after DENSPM treatment and cell cycle kinetic effects was found. The most sensitive cell cycle phase was the S phase, followed by an effect on the G2+M phase and then the G1/S transition. The levels of a number of cell cycle regulatory proteins such as cyclin E1, cyclin A2, and cyclin B1 were lowered by DENSPM treatment, which may explain the effects on cell cycle kinetics. The two cell lines that were most sensitive to DENSPM treatment belong to the basal-like subtype of breast cancer and they were deficient with respect to p53, BRCA1, and RB1. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Alm, Kerstiu Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science4 aut0 (Swepub:lu)ke7004al |
700 | 1 | a Hegardt, Ceciliau Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)zoof-che |
700 | 1 | a Staaf, Johanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-jst |
700 | 1 | a Jönsson, Göran Bu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-gjo |
700 | 1 | a Larsson, Sarau Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups4 aut0 (Swepub:lu)mats-sla |
700 | 1 | a Oredsson, Stinau Lund University,Lunds universitet,Funktionell zoologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Functional zoology,Department of Biology,Faculty of Science4 aut0 (Swepub:lu)zoof-sor |
710 | 2 | a Biologiska institutionenb Naturvetenskapliga fakulteten4 org |
773 | 0 | t Anti-Cancer Drugsg 19:4, s. 359-368q 19:4<359-368x 0959-4973 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/18454046?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1097/CAD.0b013e3282f7f518y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/1154588 |
856 | 4 8 | u https://doi.org/10.1097/CAD.0b013e3282f7f518 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.