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A Comparison of Hos...
A Comparison of Host Responses to Infection with Wild-Type Avian Influenza Viruses in Chickens and Tufted Ducks
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- Naguib, Mahmoud (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Eriksson, Per (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Jax, Elinor (författare)
- Max Planck Inst Anim Behav, Germany;Univ Konstanz, Germany,Department of Migration, Max Planck Institute of Animal Behavior, Radolfzell, Germany;Department of Biology, University of Konstanz, Konstanz, Germany
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- Wille, Michelle (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Lindskog, Cecilia (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin
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- Bröjer, Caroline (författare)
- Department of Pathology and Wildlife Diseases, National Veterinary Institute (SVA), Uppsala, Sweden
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- Krambrich, Janina (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Waldenström, Jonas, 1975- (författare)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden
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- Kraus, Robert H. S. (författare)
- Max Planck Inst Anim Behav, Germany;Univ Konstanz, Germany,Department of Migration, Max Planck Institute of Animal Behavior, Radolfzell, Germany;Department of Biology, University of Konstanz, Konstanz, Germany
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- Larson, Göran, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Lundkvist, Åke (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Olsen, Björn (författare)
- Uppsala universitet,Infektionsmedicin
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- Järhult, Josef D., 1975- (författare)
- Uppsala universitet,Infektionsmedicin
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- Ellström, Patrik (författare)
- Uppsala universitet,Infektionsmedicin,Klinisk mikrobiologi
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(creator_code:org_t)
- American Society for Microbiology, 2023
- 2023
- Engelska.
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Ingår i: Microbiology Spectrum. - : American Society for Microbiology. - 2165-0497. ; 11:4
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Cross-species transmission of influenza A virus (IAV) from wild waterfowl to poultry is the first step in a chain of events that can ultimately lead to exposure and infection of humans. Herein, we study the outcome of infection with eight different mallard-origin IAV subtypes in two different avian hosts: tufted ducks and chickens. We found that infection and shedding patterns as well as innate immune responses were highly dependent on viral subtypes, host species, and inoculation routes. For example, intraoesophageal inoculation, commonly used in mallard infection experiments, resulted in no infections in contrast to oculonasal inoculation, suggesting a difference in transmission routes. Despite H9N2 being endemic in chickens, inoculation of mallard-origin H9N2 failed to cause viable infection beyond 1 day postinfection in our study design. The innate immune responses were markedly different in chickens and tufted ducks, and despite the presence of retinoic acid-inducible gene-I (RIG-I) in tufted duck transcriptomes, it was neither up nor downregulated in response to infection. Overall, we have revealed the heterogeneity of infection patterns and responses in two markedly different avian hosts following a challenge with mallard-origin IAV. These virus-host interactions provide new insights into important aspects of interspecies transmission of IAV.IMPORTANCE Our current findings highlight important aspects of IAV infection in birds that have implications for our understanding of its zoonotic ecology. In contrast to mallards where the intestinal tract is the main site of IAV replication, chickens and tufted ducks show limited or no signs of intestinal infection suggesting that the fecal-oral transmission route might not apply to all bird IAV host species. Our results indicate that mallard-origin IAVs undergo genetic changes upon introduction into new hosts, suggesting rapid adaptation to a new environment. However, similar to the mallard, chickens and tufted ducks show a limited immune response to infection with low pathogenic avian influenza viruses. These findings and future studies in different IAV hosts are important for our understanding of barriers to IAV transmission between species and ultimately from the wild reservoir to humans. Our current findings highlight important aspects of IAV infection in birds that have implications for our understanding of its zoonotic ecology. In contrast to mallards where the intestinal tract is the main site of IAV replication, chickens and tufted ducks show limited or no signs of intestinal infection suggesting that the fecal-oral transmission route might not apply to all bird IAV host species.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- influenza virus
- gene expression
- innate immunity
- adaptive viral mutations
- Zoonotisk ekologi
- Zoonotic Ecology
- influenza virus
- gene expression
- innate immunity
- adaptive viral mutations
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Naguib, Mahmoud
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Eriksson, Per
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Jax, Elinor
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Wille, Michelle
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Lindskog, Cecili ...
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Bröjer, Caroline
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Krambrich, Janin ...
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Waldenström, Jon ...
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Kraus, Robert H. ...
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Larson, Göran, 1 ...
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Lundkvist, Åke
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Olsen, Björn
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Järhult, Josef D ...
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Ellström, Patrik
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