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Sökning: WFRF:(Janefjord Camilla) > The role of LAMP-2 ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004360nam a2200433 4500
001oai:DiVA.org:liu-122345
003SwePub
008151029s2015 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1223452 URI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a ovr2 swepub-publicationtype
1001 a Boman, Andreau Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten4 aut0 (Swepub:liu)andar41
2451 0a The role of LAMP-2 in AβPP processing and Aβ degradation; implications for Alzheimer’s Disease
264 1c 2015
338 a print2 rdacarrier
520 a Dysfunction in the lysosomal network, i.e., the endosomal, lysosomal and autophagy systems, are implicated in the pathways in Alzheimer’s disease brain pathology. This dysfunction is mirrored in the cerebrospinal fluid where a specific subset of lysosomal network proteins are found at elevated levels, lysosomal associated membrane protein-2 (LAMP-2) being one of the identified lysosomal proteins. Here we report that hippocampus and frontal cortex in Alzheimer’s disease cases have increased mRNA and protein expression of LAMP-2, and thus these brain areas are likely involved in the increased LAMP-2 levels seen in cerebrospinal fluid from Alzheimer’s disease patients. The increased LAMP-2 levels correlated with increased levels of β-amyloid1-42 (Aβ1-42). Oligomeric Aβ1-42 caused an upregulation of intracellular LAMP-2 in neuroblastoma cells, but did not trigger the release of LAMP-2 to the extracellular milieu, indicating that other cell types or mechanisms are responsible for the LAMP-2 release seen in cerebrospinal fluid. Overexpression of LAMP-2 in neuroblastoma cells caused a trend of reduction of secreted Aβ1-42 and changed the processing pattern of the Aβ precursor protein. These results indicate that Aβ1-42 mediated increase of LAMP-2 expression can act as a regulator of Aβ generation and secretion. LAMP-2 overexpression did not change the cellular uptake of extracellularly added Aβ1-42, but caused a delayed clearance of Aβ1-42. Whether the prolonged intracellular localization of Aβ1-42 in LAMP-2 overexpressing cells can change the transmission or degradation of Aβ remains to be investigated.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng
653 a AβPP processing
653 a Alzheimer’s disease
653 a β-amyloid
653 a autophagy
653 a LAMP-2
653 a lysosome
7001 a Janefjord, Camillau Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,CBD Solutions, Stockholm, Sweden4 aut0 (Swepub:liu)camja19
7001 a Halliday, Glendau Neuroscience Research Australia and University of New South Wales, Sydney, Australia4 aut
7001 a Zetterberg, Henriku Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden / UCL Institute of Neurology, Queen Square, London, United Kingdom4 aut
7001 a Blennow, Kaju Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden4 aut
7001 a Garner, Brettu Illawarra Health and Medical Research Institute, Wollongong, Australia / School of Biological Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, Australia4 aut
7001 a Miller, Bruceu Memory and Aging Center, University of California, San Francisco, United States4 aut
7001 a Saftig, Paulu Institute of Biochemistry, Christian-Albrechts-University of Kiel, Kiel, Germany4 aut
7001 a Kågedal, Katarinau Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten4 aut0 (Swepub:liu)katka10
7102 a Linköpings universitetb Avdelningen för cellbiologi4 org
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122345

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