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Sökning: WFRF:(Jung Peter) > (2010-2014) > Comprehensive analy...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008068naa a2200625 4500
001oai:DiVA.org:umu-46219
003SwePub
008110829s2011 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-462192 URI
0247 a https://doi.org/10.1038/nature097252 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Kharchenko, Peter Vu Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA4 aut
2451 0a Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
264 c 2010-12-22
264 1b Springer Science and Business Media LLC,c 2011
338 a print2 rdacarrier
520 a Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.
7001 a Alekseyenko, Artyom Au Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA4 aut
7001 a Schwartz, Yuri Bu Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA4 aut0 (Swepub:umu)yusc0002
7001 a Minoda, Akiu Department of Molecular and Cell Biology, University of California at Berkeley, and Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California 94720, USA4 aut
7001 a Riddle, Nicole Cu Department of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA4 aut
7001 a Ernst, Jasonu MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139, USA,Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA4 aut
7001 a Sabo, Peter Ju Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA4 aut
7001 a Larschan, Ericau Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02906, USA4 aut
7001 a Gorchakov, Andrey Au Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA4 aut
7001 a Gu, Tingtingu Department of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA4 aut
7001 a Linder-Basso, Danielau Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA4 aut
7001 a Plachetka, Annetteu Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA4 aut
7001 a Shanower, Gregoryu Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA4 aut
7001 a Tolstorukov, Michael Yu Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA4 aut
7001 a Luquette, Lovelace Ju Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA4 aut
7001 a Xi, Ruibinu Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA4 aut
7001 a Jung, Youngsook Lu Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA4 aut
7001 a Park, Richard Wu Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts 02115, USA4 aut
7001 a Bishop, Eric Pu Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts 02115, USA4 aut
7001 a Canfield, Theresa Ku Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA4 aut
7001 a Sandstrom, Richardu Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA4 aut
7001 a Thurman, Robert Eu Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA4 aut
7001 a MacAlpine, David Mu Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA4 aut
7001 a Stamatoyannopoulos, John Au Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA,Department of Medicine, University of Washington, Seattle, Washington 98195, USA4 aut
7001 a Kellis, Manolisu MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139, USA,Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA4 aut
7001 a Elgin, Sarah C Ru Department of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA4 aut
7001 a Kuroda, Mitzi Iu Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA4 aut
7001 a Pirrotta, Vincenzou Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA4 aut
7001 a Karpen, Gary Hu Department of Molecular and Cell Biology, University of California at Berkeley, and Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California 94720, USA4 aut
7001 a Park, Peter Ju Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA and Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA4 aut
7102 a Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USAb Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA4 org
7730 t Natured : Springer Science and Business Media LLCg 471:7339, s. 480-485q 471:7339<480-485x 0028-0836x 1476-4687
8564 u http://compbio.mit.edu/publications/47_Kharchenko_Nature_10.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46219
8564 8u https://doi.org/10.1038/nature09725

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