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Detection of High- ...
Detection of High- and Low-Risk HPV DNA in Archived Breast Carcinoma Tissues from Ethiopian Women
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- Gebregzabher, Endale (författare)
- Department of Biochemistry, St. Paul's Hospital Millennium Medical College, Ethiopia
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- Seifu, Daniel (författare)
- Department of Biochemistry, Division of Basic Sciences, University of Global Health Equity, Kigali, Rwanda
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- Tigneh, Wondemagegnhu (författare)
- Department of Oncology, School of Medicine, Addis Ababa University, Ethiopia
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- Bokretsion, Yonas (författare)
- Department of Pathology, School of Medicine, Addis Ababa University, Ethiopia
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- Bekele, Abebe (författare)
- Deputy Vice Chancellor, University of Global Health Equity, Kigali, Rwanda
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- Abebe, Markos (författare)
- Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia
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- Lillsunde-Larsson, Gabriella, 1971- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper
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- Karlsson, Christina, 1968- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper
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- Karlsson, Mats, 1960- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine
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Department of Biochemistry, St Paul's Hospital Millennium Medical College, Ethiopia Department of Biochemistry, Division of Basic Sciences, University of Global Health Equity, Kigali, Rwanda (creator_code:org_t)
- Hindawi Publishing Corporation, 2021
- 2021
- Engelska.
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Ingår i: International Journal of Breast Cancer. - : Hindawi Publishing Corporation. - 2090-3170 .- 2090-3189. ; 2021
- Relaterad länk:
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https://doi.org/10.1...
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https://downloads.hi...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Human papilloma virus (HPV) is involved in the development of cancer of the cervix, mouth and throat, anus, penis, vulva, or vagina, but it has not been much considered as a cause of breast cancer. Recently, a number of investigations have linked breast cancer to viral infections. High-risk HPV types, predominantly HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59, are established as carcinogens in humans. In this study we aimed to detect 19 high-risk and 9 low-risk HPVs from archived breast tumor tissue among Ethiopian women.Methods: In this study, 75 breast cancer patients from Tikur Anbassa Specialized Hospital in Addis Ababa (Ethiopia) were included. HPV detection and genotyping were done using the novel Anyplex™ II HPV28 Detection Assay at the Orebro University Hospital, Sweden. The Anyplex™ II PCR System detects 19 high-risk HPV types (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 69, 73, and 82) and 9 low-risk HPV types (6, 11, 40, 42, 43, 44, 54, 61, and 70). IHC for p16 was done using an automated system, the Dako Autostainer Link.Results: Out of the 75 valid tests, two were found to be positive (2.7%) for HPV. One of the cases was positive for the high-risk HPV16 genotype while the other was positive both for the high-risk HPV39 and the low-risk HPV6. The cell cycle protein p16 was highly expressed in the case positive for the high-risk HPV16, but it was not expressed in the case positive for HPV39.Conclusion: The prevalence of HPV is low in Ethiopian breast cancer patients, but the role played by HPV in breast carcinogenesis among Ethiopian breast cancer patients cannot be commented based on these observations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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