WFRF:(Kashuba Vladimir I)
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miRNA-218 contributes to the regulation of D-glucuronyl C5-epimerase expression in normal and tumor breast tissues
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- Prudnikova, Tatiana Y (författare)
- Russian Academy of Medical Science, Russia
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- Mostovich, Luydmila A (författare)
- Russian Academy of Medical Science, Russia
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- Kashuba, Vladimir I (författare)
- Karolinska Institutet
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- (creator_code:org_t)
- 2014-10-27
- 2012
- Engelska.
- Ingår i: Epigenetics. - : Landes Bioscience. - 1559-2294 .- 1559-2308. ; 7:10, s. 1109-1114
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- microRNAs (miRNAs) are key posttranscriptional regulators of gene expression. In the present study, regulation of tumor-suppressor gene D-glucuronyl C5-epimerase (GLCE) by miRNA-218 was investigated. Significant downregulation of miRNA-218 expression was shown in primary breast tumors. Exogenous miRNA-218/anti-miRNA-218 did not affect GLCE mRNA but regulated GLCE protein level in MCF7 breast carcinoma cells in vitro. Comparative analysis showed a positive correlation between miRNA-218 and GLCE mRNA, and negative correlation between miRNA-218 and GLCE protein levels in breast tissues and primary tumors in vivo, supporting a direct involvement of miRNA-218 in posttranscriptional regulation of GLCE in human breast tissue. A common scheme for the regulation of GLCE expression in normal and tumor breast tissues is suggested.
Nyckelord
- miRNA
- D-glucuronyl C5-epimerase
- GLCE
- tumor-suppressor gene
- expression
- heparan sulphate proteoglycan
- biosynthesis
- breast cancer
- TECHNOLOGY
- TEKNIKVETENSKAP
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Mostovich, Luydm ...
- Kashuba, Vladimi ...
- Ernberg, Ingemar
- Zabarovsky, Euge ...
- Grigorieva, Elvi ...
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- Epigenetics
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