Search: WFRF:(Kelly Brendan) > Aryl amino acetamid...
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000 | 09287naa a2200685 4500 | |
001 | oai:DiVA.org:umu-227301 | |
003 | SwePub | |
008 | 240703s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2273012 URI |
024 | 7 | a https://doi.org/10.1038/s41467-024-49491-82 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dans, Madeline G.u Burnet Institute, VIC, Melbourne, Australia; Walter and Eliza Hall Institute, VIC, Parkville, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
245 | 1 0 | a Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1 |
264 | 1 | b Springer Nature,c 2024 |
338 | a electronic2 rdacarrier | |
520 | a With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. Here, we select parasites resistant to M-833 and identify mutations in the START lipid transfer protein (PF3D7_0104200, PfSTART1). Introducing PfSTART1 mutations into wildtype parasites reproduces resistance to M-833 as well as to more potent analogues. PfSTART1 binding to the analogues is validated using organic solvent-based Proteome Integral Solubility Alteration (Solvent PISA) assays. Imaging of invading merozoites shows the inhibitors prevent the development of ring-stage parasites potentially by inhibiting the expansion of the encasing parasitophorous vacuole membrane. The PfSTART1-targeting compounds also block transmission to mosquitoes and with multiple stages of the parasite’s lifecycle being affected, PfSTART1 represents a drug target with a new mechanism of action. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
700 | 1 | a Boulet, Coralieu Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland4 aut |
700 | 1 | a Watson, Gabrielle M.u Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Nguyen, Williamu Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Dziekan, Jerzy M.u Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Evelyn, Cindyu Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Reaksudsan, Kitsanapongu Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Mehra, Somyau Burnet Institute, VIC, Melbourne, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia4 aut |
700 | 1 | a Razook, Zahrau Burnet Institute, VIC, Melbourne, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia4 aut |
700 | 1 | a Geoghegan, Niall D.u Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Mlodzianoski, Michael J.u Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Goodman, Christopher Deanu School of Biosciences, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Ling, Dawson B.u Burnet Institute, VIC, Melbourne, Australia4 aut |
700 | 1 | a Jonsdottir, Thorey K.u Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne, VIC, Parkville, Australia; The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå, Sweden4 aut0 (Swepub:umu)thjo0151 |
700 | 1 | a Tong, Joshuau Walter and Eliza Hall Institute, VIC, Parkville, Australia4 aut |
700 | 1 | a Famodimu, Mufuliat Toyinu Department of Infection Biology, Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom4 aut |
700 | 1 | a Kristan, Mojcau Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom4 aut |
700 | 1 | a Pollard, Harryu Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom4 aut |
700 | 1 | a Stewart, Lindsay B.u Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom4 aut |
700 | 1 | a Brandner-Garrod, Lukeu Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom4 aut |
700 | 1 | a Sutherland, Colin J.u Department of Infection Biology, Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom4 aut |
700 | 1 | a Delves, Michael J.u Department of Infection Biology, Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom4 aut |
700 | 1 | a McFadden, Geoffrey I.u School of Biosciences, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Barry, Alyssa E.u Burnet Institute, VIC, Melbourne, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia4 aut |
700 | 1 | a Crabb, Brendan S.u Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne, VIC, Parkville, Australia; Monash University, VIC, Melbourne, Australia4 aut |
700 | 1 | a de Koning-Ward, Tania F.u Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia4 aut |
700 | 1 | a Rogers, Kelly L.u Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Cowman, Alan F.u Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Tham, Wai-Hongu Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Sleebs, Brad E.u Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia4 aut |
700 | 1 | a Gilson, Paul R.u Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne, VIC, Parkville, Australia4 aut |
710 | 2 | a Burnet Institute, VIC, Melbourne, Australia; Walter and Eliza Hall Institute, VIC, Parkville, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australiab Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland4 org |
773 | 0 | t Nature Communicationsd : Springer Natureg 15:1q 15:1x 2041-1723 |
856 | 4 | u https://doi.org/10.1038/s41467-024-49491-8y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1881371/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-227301 |
856 | 4 8 | u https://doi.org/10.1038/s41467-024-49491-8 |
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