Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function

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Fältnamn	Indikatorer	Metadata
000		06858naa a2201297 4500
001		oai:DiVA.org:uu-231328
003		SwePub
008		140907s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2313282 URI
024	7	a https://doi.org/10.1371/journal.pone.01007762 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Tang, Wenbo4 aut
245	1 0	a Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function
264		c 2014-07-01
264	1	b Public Library of Science (PLoS),c 2014
338		a electronic2 rdacarrier
520		a Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. Methods: We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis. Results: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P = 5.71 x 10(-7)). In addition, meta-analysis using the five cohorts with >= 3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P = 2.18 x 10(-8)) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively. Conclusions: In this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
700	1	a Kowgier, Matthew4 aut
700	1	a Loth, Daan W.4 aut
700	1	a Artigas, Maria Soler4 aut
700	1	a Joubert, Bonnie R.4 aut
700	1	a Hodge, Emily4 aut
700	1	a Gharib, Sina A.4 aut
700	1	a Smith, Albert V.4 aut
700	1	a Ruczinski, Ingo4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Mathias, Rasika A.4 aut
700	1	a Harris, Tamara B.4 aut
700	1	a Hansel, Nadia N.4 aut
700	1	a Launer, Lenore J.4 aut
700	1	a Barnes, Kathleen C.4 aut
700	1	a Hansen, Joyanna G.4 aut
700	1	a Albrecht, Eva4 aut
700	1	a Aldrich, Melinda C.4 aut
700	1	a Allerhand, Michael4 aut
700	1	a Barr, R. Graham4 aut
700	1	a Brusselle, Guy G.4 aut
700	1	a Couper, David J.4 aut
700	1	a Curjuric, Ivan4 aut
700	1	a Davies, Gail4 aut
700	1	a Deary, Ian J.4 aut
700	1	a Dupuis, Josee4 aut
700	1	a Fall, Toveu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)tovfa878
700	1	a Foy, Millennia4 aut
700	1	a Franceschini, Nora4 aut
700	1	a Gao, Wei4 aut
700	1	a Glaeser, Sven4 aut
700	1	a Gu, Xiangjun4 aut
700	1	a Hancock, Dana B.4 aut
700	1	a Heinrich, Joachim4 aut
700	1	a Hofman, Albert4 aut
700	1	a Imboden, Medea4 aut
700	1	a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425
700	1	a James, Alan4 aut
700	1	a Karrasch, Stefan4 aut
700	1	a Koch, Beate4 aut
700	1	a Kritchevsky, Stephen B.4 aut
700	1	a Kumar, Ashish4 aut
700	1	a Lahousse, Lies4 aut
700	1	a Li, Guo4 aut
700	1	a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind
700	1	a Lindgren, Cecilia4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Lohman, Kurt4 aut
700	1	a Lumley, Thomas4 aut
700	1	a McArdle, Wendy L.4 aut
700	1	a Meibohm, Bernd4 aut
700	1	a Morris, Andrew P.4 aut
700	1	a Morrison, Alanna C.4 aut
700	1	a Musk, Bill4 aut
700	1	a North, Kari E.4 aut
700	1	a Palmer, Lyle J.4 aut
700	1	a Probst-Hensch, Nicole M.4 aut
700	1	a Psaty, Bruce M.4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Rotter, Jerome I.4 aut
700	1	a Schulz, Holger4 aut
700	1	a Smith, Lewis J.4 aut
700	1	a Sood, Akshay4 aut
700	1	a Starr, John M.4 aut
700	1	a Strachan, David P.4 aut
700	1	a Teumer, Alexander4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a Voelzke, Henry4 aut
700	1	a Voorman, Arend4 aut
700	1	a Wain, Louise V.4 aut
700	1	a Wells, Martin T.4 aut
700	1	a Wilk, Jemma B.4 aut
700	1	a Williams, O. Dale4 aut
700	1	a Heckbert, Susan R.4 aut
700	1	a Stricker, Bruno H.4 aut
700	1	a London, Stephanie J.4 aut
700	1	a Fornage, Myriam4 aut
700	1	a Tobin, Martin D.4 aut
700	1	a O'Connor, George T.4 aut
700	1	a Hall, Ian P.4 aut
700	1	a Cassano, Patricia A.4 aut
710	2	a Uppsala universitetb Molekylär epidemiologi4 org
773	0	t PLOS ONEd : Public Library of Science (PLoS)g 9:7, s. e100776-q 9:7<e100776-x 1932-6203
856	4	u https://uu.diva-portal.org/smash/get/diva2:744196/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100776&type=printable
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231328
856	4 8	u https://doi.org/10.1371/journal.pone.0100776

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Av författaren/redakt...: Tang, Wenbo; Kowgier, Matthew; Loth, Daan W.; Artigas, Maria S ...; Joubert, Bonnie ...; Hodge, Emily; visa fler...; Gharib, Sina A.; Smith, Albert V.; Ruczinski, Ingo; Gudnason, Vilmun ...; Mathias, Rasika ...; Harris, Tamara B ...; Hansel, Nadia N.; Launer, Lenore J ...; Barnes, Kathleen ...; Hansen, Joyanna ...; Albrecht, Eva; Aldrich, Melinda ...; Allerhand, Micha ...; Barr, R. Graham; Brusselle, Guy G ...; Couper, David J.; Curjuric, Ivan; Davies, Gail; Deary, Ian J.; Dupuis, Josee; Fall, Tove; Foy, Millennia; Franceschini, No ...; Gao, Wei; Glaeser, Sven; Gu, Xiangjun; Hancock, Dana B.; Heinrich, Joachi ...; Hofman, Albert; Imboden, Medea; Ingelsson, Erik; James, Alan; Karrasch, Stefan; Koch, Beate; Kritchevsky, Ste ...; Kumar, Ashish; Lahousse, Lies; Li, Guo; Lind, Lars; Lindgren, Cecili ...; Liu, Yongmei; Lohman, Kurt; Lumley, Thomas; McArdle, Wendy L ...; Meibohm, Bernd; Morris, Andrew P ...; Morrison, Alanna ...; Musk, Bill; North, Kari E.; Palmer, Lyle J.; Probst-Hensch, N ...; Psaty, Bruce M.; Rivadeneira, Fer ...; Rotter, Jerome I ...; Schulz, Holger; Smith, Lewis J.; Sood, Akshay; Starr, John M.; Strachan, David ...; Teumer, Alexande ...; Uitterlinden, An ...; Voelzke, Henry; Voorman, Arend; Wain, Louise V.; Wells, Martin T.; Wilk, Jemma B.; Williams, O. Dal ...; Heckbert, Susan ...; Stricker, Bruno ...; London, Stephani ...; Fornage, Myriam; Tobin, Martin D.; O'Connor, George ...; Hall, Ian P.; Cassano, Patrici ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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