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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003938naa a2200529 4500
001oai:lup.lub.lu.se:a2927d4d-d515-499a-8b73-8d202fc294c4
003SwePub
008160401s2002 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/3265842 URI
0247 a https://doi.org/10.1002/ijc.106412 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Moller, P4 aut
2451 0a Survival in prospectively ascertained familial breast cancer: Analysis of a series stratified by tumour characteristics, BRCA mutations and oophorectomy
264 c 2002-08-21
264 1b Wiley,c 2002
520 a Dedicated clinics have been established for the early diagnosis and treatment of women at risk for inherited breast cancer, but the effects of such interventions are currently unproven. This second report on prospectively diagnosed inherited breast cancer from the European collaborating centres supports the previous conclusions and adds information on genetic heterogeneity and the effect of oophorectomy. Of 249 patients, 20% had carcinoma in situ (CIS), 54% had infiltrating cancer without spread (CaNO) and 26% had cancer with spread (CaN+). Five-year survival was 100% for CIS, 94% for CaNO and 72% for CaN+ (p = 0.007). Thirty-six patients had BRCA1 mutations, and 8 had BRCA2 mutations. Presence of BRCA1 mutation was associated with infiltrating cancer, high grade and lack of oestrogen receptor (p < 0.05 for all 3 characteristics). For BRCA1 mutation carriers, 5-year survival was 63% vs. 91% for noncarriers (p = 0.04). For CaNO patients, mutation carriers had 75% S-year disease-free survival vs. 96% for noncarriers (p = 0.01). Twenty-one of the mutation carriers had undergone prophylactic oophorectomy, prior to or within 6 months of diagnosis in 13 cases. All but I relapse occurred in the I S who had kept their ovaries, (p < 0.01); no relapse occurred in those who had removed the ovaries within 6 months (p = 0.04) Contralateral cancer was more frequently observed in mutation noncarriers, but this finding did not reach statistical significance. Our findings support the concept that BRCA1 cancer is biologically different from other inherited breast cancers. While current screening protocols appear satisfactory for the majority of women at risk of familial breast cancer, this may not be the case for BRCA1 mutation carriers. The observed effect of oophorectomy was striking.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a oophorectomy
653 a breast cancer
653 a BRCA1
653 a prognosis
653 a survival
7001 a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo
7001 a Evans, D G4 aut
7001 a Haites, N4 aut
7001 a Reis, MM4 aut
7001 a Vasen, H4 aut
7001 a Anderson, E4 aut
7001 a Steel, C M4 aut
7001 a Apold, J4 aut
7001 a Goudie, D4 aut
7001 a Howell, A4 aut
7001 a Lalloo, F4 aut
7001 a Maehle, L4 aut
7001 a Gregory, H4 aut
7001 a Heimdal, K4 aut
7102 a Bröstcancer-genetikb Sektion I4 org
7730 t International Journal of Cancerd : Wileyg 101:6, s. 555-559q 101:6<555-559x 0020-7136
8564 u http://dx.doi.org/10.1002/ijc.10641y FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.10641
8564 8u https://lup.lub.lu.se/record/326584
8564 8u https://doi.org/10.1002/ijc.10641

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