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Elevated levels of ...
Elevated levels of IL-12/IL-23p40 in Nova Scotia Duck Tolling Retrievers with autoimmune disease and lymphoma
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- Nilsson, Malin (author)
- Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.
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- Kozyrev, Sergey V. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Saellstrom, Sara (author)
- Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.
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- Johansson, Siri (author)
- Swedish Univ Agr Sci, Dept Anim Biosci, Uppsala, Sweden.;Anicura Kalmarsund Anim Hosp, Kalmar, Sweden.
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- Andersson, Goeran (author)
- Swedish Univ Agr Sci, Dept Anim Biosci, Uppsala, Sweden.
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- Lindblad-Toh, Kerstin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, Cambridge, MA USA.
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- Hansson-Hamlin, Helene (author)
- Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.
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- Ronnberg, Henrik (author)
- Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.
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Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden Institutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)
- Nature Publishing Group, 2024
- 2024
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 14:1
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- The Nova Scotia Duck Tolling Retriever (NSDTR) is predisposed to immune mediated rheumatic disease (IMRD), steroid-responsive meningitis-arteritis (SRMA) and certain forms of cancer. Cytokines are the main regulators of the immune system. Interleukin 2 is a cytokine involved in activation of T regulatory cells, playing a role in central tolerance and tumor immunity. Interleukin 12 and interleukin 23 share the same subunit, p40, and are both pro-inflammatory cytokines. The aim of this study was to compare levels of IL-2 in healthy NSDTRs to those with cancer or autoimmune disease and to compare levels of IL-12/IL-23p40 in healthy NSDTRs and beagles versus NSDTRs with cancer or autoimmune disease. 62 dogs were included in the analysis of IL-12/IL-23p40; healthy NSDTRs (n = 16), healthy beagles (n = 16), NSDTRs autoimmune (n = 18) and NDSTRs lymphoma/mastocytoma (n = 12) and 68 dogs for IL-2; healthy (n = 20), autoimmune (n = 36) and lymphoma/mastocytoma/adenocarcinoma (n = 12). NSDTRs with autoimmune disease had higher levels of IL-12/IL-23p40 compared to healthy dogs (p = 0.008). NSDTRs with lymphoma also had higher levels of IL-12/IL-23p40 compared to healthy NSDTRs (p = 0.002). There was no difference in levels of IL-2 between healthy and diseased NSDTR. Statistical analysis was performed using Bonferroni corrections for multiple testing. These findings can contribute to the knowledge of autoimmune disease and cancer in dogs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Autoimmune
- Immune-mediated rheumatic disease
- Steroid-responsive meningitis-arteritis
- IMRD
- SRMA
- NSDTR
- Canine tumors
- Cytokines
Publication and Content Type
- ref (subject category)
- art (subject category)
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