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Persistent Aspergil...
Persistent Aspergillus fumigatus infection in cystic fibrosis : impact on lung function and role of treatment of asymptomatic colonization-a registry-based case-control study
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- Blomquist, Axel (författare)
- Lund University,Lunds universitet,Luftvägar, patogener, immunförsvar,Forskargrupper vid Lunds universitet,Airways, pathogens, innate immunity,Lund University Research Groups,Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Sect Infect Med, BMC B14, S-22184 Lund, Sweden.
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- Inghammar, Malin (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Sect Infect Med, BMC B14, S-22184 Lund, Sweden.
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- Al Shakirchi, Mahasin (författare)
- Karolinska Institutet
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- Ericson, Petrea (författare)
- Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Resp Med, S-41345 Gothenburg, Sweden.
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- Krantz, Christina (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- Svedberg, Marcus, 1975 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sahlgrenska Acad, Dept Paediat, Inst Clin Sci, Gothenburg, Sweden.,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Lindblad, Anders, 1955 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Sahlgrenska Acad, Dept Paediat, Inst Clin Sci, Gothenburg, Sweden.,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Påhlman, Lisa I (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Luftvägar, patogener, immunförsvar,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Airways, pathogens, innate immunity,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Sect Infect Med, BMC B14, S-22184 Lund, Sweden.;Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden.
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(creator_code:org_t)
- 2022-07-05
- 2022
- Engelska.
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Ingår i: BMC Pulmonary Medicine. - : Springer Science and Business Media LLC. - 1471-2466. ; 22:1
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Aspergillus fumigatus is the most common filamentous fungus isolated from the airways of people with cystic fibrosis (CF). The aim of this study was to investigate how chronic A. fumigatus colonization affects lung function in people with CF, to identify risk factors for colonization, and to evaluate antifungal treatment of asymptomatic Aspergillus colonization.METHODS: Data from 2014-2018 was collected from the Swedish CF registry and medical records. Baseline data before the start of A. fumigatus colonization was compared with the two succeeding years to evaluate how colonization and treatment affected lung function and other clinical aspects.RESULTS: A total of 437 patients were included, of which 64 (14.6%) became colonized with A. fumigatus during the study period. Inhaled antibiotics was associated with A. fumigatus colonization (adjusted OR 3.1, 95% CI 1.6-5.9, p < 0.05). Fungal colonization was not associated with a more rapid lung function decline or increased use of IV-antibiotics compared to the non-colonized group, but patients with A. fumigatus had more hospital days, a higher increase of total IgE, and higher eosinophil counts. In the Aspergillus group, 42 patients were considered to be asymptomatic. Of these, 19 patients received antifungal treatment. Over the follow up period, the treated group had a more pronounced decrease in percent predicted Forced Expiratory Volume in one second (ppFEV1) compared to untreated patients (- 8.7 vs - 1.4 percentage points, p < 0.05).CONCLUSION: Inhaled antibiotics was associated with A. fumigatus colonization, but no association was found between persistent A. fumigatus and subsequent lung function decline. No obvious benefits of treating asymptomatic A. fumigatus colonization were demonstrated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Anti-Bacterial Agents/therapeutic use
- Antifungal Agents/therapeutic use
- Aspergillus fumigatus
- Asymptomatic Infections
- Case-Control Studies
- Cystic Fibrosis/complications
- Humans
- Lung
- Persistent Infection
- Registries
- Cystic fibrosis
- Cystic fibrosis
- Lung function
- Antifungal
- treatment
- function decline
- Respiratory System
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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