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Early familial dila...
Early familial dilated cardiomyopathy : identification with determination of disease state parameter from cine MR image data
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- Koikkalainen, Juha R. (författare)
- VTT Technical Research Centre of Finland, Tampere, Finland
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- Antila, Margareta (författare)
- Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland
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- Lötjönen, Jyrki M. P. (författare)
- VTT Technical Research Centre of Finland, Tampere, Finland
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- Heliö, Tiina (författare)
- Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
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- Lauerma, Kirsi (författare)
- Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland
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- Kivistö, Sari M. (författare)
- Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland
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- Sipola, Petri (författare)
- Department of Radiology, Kuopio University Hospital, Kuopio, Finland
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- Kaartinen, Maija A. (författare)
- Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
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- Kärkkäinen, Satu T. J. (författare)
- Department of Medicine, Kuopio University Hospital, Kuopio, Finland
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- Reissell, Eeva (författare)
- Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
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- Kuusisto, Johanna (författare)
- Department of Medicine, Kuopio University Hospital, Kuopio, Finland
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- Laakso, Markku (författare)
- Department of Medicine, Kuopio University Hospital, Kuopio, Finland
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- Oresic, Matej, 1967- (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
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- Nieminen, Markku S. (författare)
- Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
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- Peuhkurinen, Keijo J. (författare)
- Department of Medicine, Kuopio University Hospital, Kuopio, Finland
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(creator_code:org_t)
- Radiological Society of North America, Inc, 2008
- 2008
- Engelska.
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Ingår i: Radiology. - : Radiological Society of North America, Inc. - 0033-8419 .- 1527-1315. ; 249:1, s. 88-96
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PURPOSE: To characterize early changes in cardiac anatomy and function for lamin A/C gene (LMNA) mutation carriers by using magnetic resonance (MR) imaging and to develop tools to analyze and visualize the findings.MATERIALS AND METHODS: The ethical review board of the institution approved the study, and informed written consent was obtained. The patient group consisted of 12 subjects, seven women (mean age, 36 years; age range, 18-54 years) and five men (mean age, 28 years; age range, 18-39 years) of Finnish origin, who were each heterozygotes with one LMNA mutation that may cause familial dilated cardiomyopathy (DCM). All the subjects were judged to be healthy with transthoracic echocardiography. The control group consisted of 14 healthy subjects, 11 women (mean age, 41 years; range, 23-54 years) and three men (mean age, 45 years; range, 34-57 years), of Finnish origin. Cine steady state free precession MR imaging was performed with a 1.5-T system. The volumes, wall thickness, and wall motion of both left ventricle (LV) and right ventricle were assessed. A method combining multiple MR image parameters was used to generate a global cardiac function index, the disease state parameter (DSP). A visual fingerprint was generated to assess the severity of familial DCM.RESULTS: The mean DSP of the patient group (0.69 +/- 0.15 [standard deviation]) was significantly higher than that of the control group (0.32 +/- 0.13) (P = .00002). One subject had an enlarged LV.CONCLUSION: Subclinical familial DCM was identified by determination of the DSP with MR imaging, and this method might be used to recognize familial DCM at an early stage.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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- Av författaren/redakt...
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Koikkalainen, Ju ...
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Antila, Margaret ...
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Lötjönen, Jyrki ...
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Heliö, Tiina
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Lauerma, Kirsi
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Kivistö, Sari M.
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visa fler...
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Sipola, Petri
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Kaartinen, Maija ...
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Kärkkäinen, Satu ...
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Reissell, Eeva
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Kuusisto, Johann ...
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Laakso, Markku
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Oresic, Matej, 1 ...
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Nieminen, Markku ...
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Peuhkurinen, Kei ...
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- MEDICIN OCH HÄLSOVETENSKAP
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Radiology
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Örebro universitet