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Genetic and Environ...
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Leone, MaricaJanssen Pharmaceutical Companies of Johnson & Johnson, Solna, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
(författare)
Genetic and Environmental Contribution to the Co-Occurrence of Endocrine-Metabolic Disorders and Depression : A Nationwide Swedish Study of Siblings
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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HighWire Press,2022
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-101424
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101424URI
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https://doi.org/10.1176/appi.ajp.21090954DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:151470791URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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OBJECTIVE: Depression is common in individuals with endocrine-metabolic disorders and vice versa, and a better understanding of the underlying factors contributing to the comorbidity of these disorders is needed. This study investigated the familial coaggregation of depression and endocrine-metabolic disorders and estimated the contribution of genetic and environmental factors to their co-occurrence.METHODS: This population-based cohort study included 2.2 million individuals born in Sweden between 1973 and 1996, with follow-up through 2013. Participants were linked to their biological parents, allowing identification of full siblings, maternal half siblings, and paternal half siblings. Diagnoses of depression and endocrine-metabolic conditions were investigated, with the latter grouped into autoimmune disorders (autoimmune hypothyroidism, Graves' disease, and type 1 diabetes) and non-autoimmune disorders (type 2 diabetes, obesity, and polycystic ovary syndrome). Logistic regression and Cox regression were used to estimate the associations between endocrine-metabolic disorders and depression within the same individual and across siblings. Quantitative genetic modeling was performed to investigate the relative contribution of genetic and environmental influences.RESULTS: Individuals with endocrine-metabolic disorders had a significantly higher risk of depression, with odds ratios ranging from 1.43 (95% CI=1.30, 1.57) for Graves' disease to 3.48 (95% CI=3.25, 3.72) for type 2 diabetes. Increased risks extended to full and half siblings. These correlations were mainly explained by shared genetic influences for non-autoimmune conditions, and by nonshared environmental factors for autoimmune disorders, especially for type 1 diabetes.CONCLUSIONS: These findings provide phenotypic and etiological insights into the co-occurrence of depression and various endocrine-metabolic conditions, which could guide future research aiming at identifying pathophysiological mechanisms and intervention targets.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kuja-Halkola, RalfKarolinska Institutet
(författare)
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Leval, AmyJanssen Pharmaceutical Companies of Johnson & Johnson, Solna, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
(författare)
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Butwicka, AgnieszkaKarolinska Institutet
(författare)
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Skov, JakobDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden; Department of Medicine, Karlstad Central Hospital, Karlstad, Sweden
(författare)
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Zhang, RuyueKarolinska Institutet
(författare)
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Liu, ShengxinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
(författare)
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Larsson, Henrik,1975-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden(Swepub:oru)hiln
(författare)
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Bergen, Sarah E.Karolinska Institutet
(författare)
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Karolinska InstitutetJanssen Pharmaceutical Companies of Johnson & Johnson, Solna, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American Journal of Psychiatry: HighWire Press179:11, s. 824-8320002-953X1535-7228
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Leone, Marica
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Kuja-Halkola, Ra ...
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Leval, Amy
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Butwicka, Agnies ...
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Skov, Jakob
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Zhang, Ruyue
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Liu, Shengxin
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Larsson, Henrik, ...
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Bergen, Sarah E.
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