Comparison of dermal vs internal light administration in human lungs using the TDLAS-GASMAS technique—Phantom studies

Larsson, JimLund University,Lunds universitet,Förbränningsfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Combustion Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH (författare)

Oxygen and water vapor content, in the lungs of a 3D-printed phantom model based on CT-images of a preterm infant, is evaluated using Tunable Diode Laser Absorption Spectroscopy (TDLAS) in Gas in Scattering Media Absorption Spectroscopy (GASMAS), that is, the TDLAS-GASMAS technique. Oxygen gas is detected through an absorption line near 764 nm and water vapor through an absorption line near 820 nm. A model with a lung containing interior structure is compared to a model with a hollow lung. Compared to the model with the hollow lung, both the mean absorption path length and the transmitted intensity are found to be lower for the model with the structured lung. A new approach, where laser light is delivered internally into the model through an optical fiber, is compared to dermal light administration, that is, illumination onto the skin, for the model with structure inside the lung. The internal light administration generally resulted in larger gas absorption, and higher signal-to-noise ratios, compared to the dermal light administration. The results from the phantom measurements show great promise for the internal illumination approach and a natural next step would be to investigate it further in clinical studies.

Leander, DennisGPX Medical AB (författare)
Lewander Xu, MärtaGPX Medical AB (författare)
Fellman, VinetaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)pedi-vfe (författare)
Bood, JoakimLund University,Lunds universitet,Förbränningsfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Combustion Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)forb-jbo (författare)
Krite Svanberg, EmilieLund University,Lunds universitet,Lunds lasercentrum, LLC,Annan verksamhet, LTH,Lunds Tekniska Högskola,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Fysiska institutionen,Institutioner vid LTH,Lund Laser Centre, LLC,Other operations, LTH,Faculty of Engineering, LTH,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)med-ekv (författare)
FörbränningsfysikFysiska institutionen (creator_code:org_t)

Av författaren/redakt...: Larsson, Jim; Leander, Dennis; Lewander Xu, Mär ...; Fellman, Vineta; Bood, Joakim; Krite Svanberg, ...

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