TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue.

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TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue.

Sjostedt, Evelina (author): Karolinska Inst, Dept Neurosci, Solnavagen 1, S-17177 Solna, Sweden.;Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.

Kolnes, Anders J (author): Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.

Olarescu, Nicoleta C (author): Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.

Mitsios, Nicholas (author): Karolinska Institutet

Hikmet Noraddin, Feria (author): Uppsala universitet,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.

Sivertsson, Åsa (author): KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap

Lindskog, Cecilia (author): Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.

Øystese, Kristin A B (author): Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.

Jørgensen, Anders P (author): Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.

Bollerslev, Jens (author): Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.

Casar Borota, Olivera (author): Uppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.;Uppsala Univ Hosp, Dept Clin Pathol, S-75185 Uppsala, Sweden.;Oslo Univ Hosp, Rikshosp, Dept Pathol, Pb 4950, N-0424 Oslo, Norway.

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Karolinska Inst, Dept Neurosci, Solnavagen 1, S-17177 Solna, Sweden;Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden. Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway. (creator_code:org_t)

2020-12-31
2020
English.
In: Cancers. - BASEL SWITZERLAND : MDPI AG. - 2072-6694. ; 13:1

Related links:: https://doi.org/10.3...; show more...; https://www.mdpi.com...; https://urn.kb.se/re...; https://doi.org/10.3...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Here, we report the investigation of transforming growth factor beta-receptor 3 like (TGFBR3L), an uncharacterised pituitary specific membrane protein, in non-neoplastic anterior pituitary gland and pituitary neuroendocrine tumours. A polyclonal antibody produced within the Human Protein Atlas project (HPA074356) was used for TGFBR3L staining and combined with SF1 and FSH for a 3-plex fluorescent protocol, providing more details about the cell lineage specificity of TGFBR3L expression. A cohort of 230 pituitary neuroendocrine tumours were analysed. In a subgroup of previously characterised gonadotroph tumours, correlation with expression of FSH/LH, E-cadherin, oestrogen (ER) and somatostatin receptors (SSTR) was explored. TGFBR3L showed membranous immunolabeling and was found to be gonadotroph cell lineage-specific, verified by co-expression with SF1 and FSH/LH staining in both tumour and non-neoplastic anterior pituitary tissues. TGFBR3L immunoreactivity was observed in gonadotroph tumours only and demonstrated intra-tumour heterogeneity with a perivascular location. TGFBR3L immunostaining correlated positively to both FSH (R = 0.290) and LH (R = 0.390) immunostaining, and SSTR3 (R = 0.315). TGFBR3L correlated inversely to membranous E-cadherin staining (R = -0.351) and oestrogen receptor β mRNA (R = -0.274). In conclusion, TGFBR3L is a novel pituitary gland specific protein, located in the membrane of gonadotroph cells in non-neoplastic anterior pituitary gland and in a subset of gonadotroph pituitary tumours.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)

Keyword

gonadotroph cells
hormone secretion
immunohistochemistry
membrane protein
pituitary gland
pituitary neuroendocrine tumours
Patologi
Pathology

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor: Sjostedt, Evelin ...; Kolnes, Anders J; Olarescu, Nicole ...; Mitsios, Nichola ...; Hikmet Noraddin, ...; Sivertsson, Åsa; show more...; Lindskog, Cecili ...; Øystese, Kristin ...; Jørgensen, Ander ...; Bollerslev, Jens; Casar Borota, Ol ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Clinical Laborat ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

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