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Sökning: WFRF:(Liu Wei Ting) > (2020-2024) > Differences in the ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005488naa a2200517 4500
001oai:DiVA.org:uu-441712
003SwePub
008210504s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4417122 URI
0247 a https://doi.org/10.3390/jpm110301982 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lin, Yi-Tingu Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 80708, Taiwan4 aut
2451 0a Differences in the Microbial Composition of Hemodialysis Patients Treated with and without β-Blockers
264 c 2021-03-12
264 1b MDPI,c 2021
338 a electronic2 rdacarrier
520 a β-blockers are commonly prescribed to treat cardiovascular disease in hemodialysis patients. Beyond the pharmacological effects, β-blockers have potential impacts on gut microbiota, but no study has investigated the effect in hemodialysis patients. Hence, we aim to investigate the gut microbiota composition difference between β-blocker users and nonusers in hemodialysis patients. Fecal samples collected from hemodialysis patients (83 β-blocker users and 110 nonusers) were determined by 16S ribosomal RNA amplification sequencing. Propensity score (PS) matching was performed to control confounders. The microbial composition differences were analyzed by the linear discriminant analysis effect size, random forest, and zero-inflated Gaussian fit model. The α-diversity (Simpson index) was greater in β-blocker users with a distinct β-diversity (Bray–Curtis Index) compared to nonusers in both full and PS-matched cohorts. There was a significant enrichment in the genus Flavonifractor in β-blocker users compared to nonusers in full and PS-matched cohorts. A similar finding was demonstrated in random forest analysis. In conclusion, hemodialysis patients using β-blockers had a different gut microbiota composition compared to nonusers. In particular, the Flavonifractor genus was increased with β-blocker treatment. Our findings highlight the impact of β-blockers on the gut microbiota in hemodialysis patients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a microbiome
653 a beta-blocker
653 a hemodialysis
653 a next-generation sequencing
653 a propensity score matching methods
7001 a Lin, Ting-Yunu Taipei Tzu Chi Hosp, Div Nephrol, Buddhist Tzu Chi Med Fdn, New Taipei 23142, Taiwan; Tzu Chi Univ, Sch Med, Hualien 97071, Taiwan4 aut
7001 a Hung, Szu-Chunu Taipei Tzu Chi Hosp, Div Nephrol, Buddhist Tzu Chi Med Fdn, New Taipei 23142, Taiwan; Tzu Chi Univ, Sch Med, Hualien 97071, Taiwan4 aut
7001 a Liu, Po-Yuu Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei 100225, Taiwan4 aut
7001 a Hung, Wei-Chunu Kaohsiung Med Univ, Dept Microbiol & Immunol, Kaohsiung 80708, Taiwan4 aut
7001 a Tsai, Wei-Chungu Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung 80708, Taiwan4 aut
7001 a Tsai, Yi-Chunu Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Gen Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung 80708, Taiwan4 aut
7001 a Delicano, Rachel Annu Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)racde587
7001 a Chuang, Yun-Shiuanu Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 80708, Taiwan4 aut
7001 a Kuo, Mei-Chuanu Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan4 aut
7001 a Chiu, Yi-Wenu Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Fac Renal Care, Coll Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan4 aut
7001 a Wu, Ping-Hsunu Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 80708, Taiwan4 aut
7102 a Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 80708, Taiwan; Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 80708, Taiwanb Taipei Tzu Chi Hosp, Div Nephrol, Buddhist Tzu Chi Med Fdn, New Taipei 23142, Taiwan; Tzu Chi Univ, Sch Med, Hualien 97071, Taiwan4 org
7730 t Journal of Personalized Medicined : MDPIg 11:3q 11:3x 2075-4426
8564 u https://doi.org/10.3390/jpm11030198y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1549184/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.mdpi.com/2075-4426/11/3/198/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441712
8564 8u https://doi.org/10.3390/jpm11030198

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