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The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

Duran-Ferrer, Marti (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
Clot, Guillem (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
Nadeu, Ferran (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
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Beekman, Renee (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
Baumann, Tycho (författare)
CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
Nordlund, Jessica (författare)
Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
Marincevic-Zuniga, Yanara (författare)
Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
Lönnerholm, Gudmar, 1941- (författare)
Uppsala universitet,Barnneurologi/Barnonkologi
Rivas-Delgado, Alfredo (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
Martin, Silvia (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.
Ordonez, Raquel (författare)
CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDISNA, Ctr Invest Med Aplicada CIMA, Pamplona, Spain.
Castellano, Giancarlo (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
Kulis, Marta (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
Queiros, Ana C. (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
Lee, Seung-Tae (författare)
Yonsei Univ, Coll Med, Dept Lab Med, Seoul, South Korea.
Wiemels, Joseph (författare)
Univ Southern Calif, Ctr Genet Epidemiol, Los Angeles, CA 90007 USA.
Royo, Romina (författare)
Univ Barcelona, Spanish Natl Bioinformat Inst, Inst Recerca Biomed IRB, Programa Conjunto Biol Computac,Barcelona Superco, Barcelona, Spain.
Puiggros, Montserrat (författare)
Univ Barcelona, Spanish Natl Bioinformat Inst, Inst Recerca Biomed IRB, Programa Conjunto Biol Computac,Barcelona Superco, Barcelona, Spain.
Lu, Junyan (författare)
European Mol Biol Lab EMBL, Heidelberg, Germany.
Gine, Eva (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
Bea, Silvia (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.
Jares, Pedro (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.
Agirre, Xabier (författare)
CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDISNA, Ctr Invest Med Aplicada CIMA, Pamplona, Spain.
Prosper, Felipe (författare)
CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDISNA, Ctr Invest Med Aplicada CIMA, Pamplona, Spain.;Univ Navarra, Clin Univ Navarra, Hematol & Cell Therapy Dept, Pamplona, Spain.
Lopez-Otin, Carlos (författare)
CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Oviedo, Inst Univ Oncol IUOPA, Dept Bioquim & Biol Mol, Oviedo, Spain.
Puente, Xose S. (författare)
CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Oviedo, Inst Univ Oncol IUOPA, Dept Bioquim & Biol Mol, Oviedo, Spain.
Oakes, Christopher C. (författare)
Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.
Zenz, Thorsten (författare)
Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA.;Univ Hosp Zurich, Dept Med Oncol & Hematol, Zurich, Switzerland.;Univ Zurich, Zurich, Switzerland.
Delgado, Julio (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
Lopez-Guillermo, Armando (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain.
Campo, Elias (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Barcelona, Fac Med, Dept Fonaments Clin, Barcelona, Spain.
Ignacio Martin-Subero, Jose (författare)
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;Univ Barcelona, Fac Med, Dept Fonaments Clin, Barcelona, Spain.;Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain.
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Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain;CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain. CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain.;IDIBAPS, Hosp Clin, Serv Hematol, Barcelona, Spain. (creator_code:org_t)
2020-11-02
2020
Engelska.
Ingår i: NATURE CANCER. - : Springer Nature. - 2662-1347. ; 1:11, s. 1066-1081
Relaterad länk:
https://doi.org/10.1...
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https://www.ncbi.nlm...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • We report a systematic analysis of the DNA methylation variability in 1,595 samples of normal cell subpopulations and 14 tumor subtypes spanning the entire human B-cell lineage. Differential methylation among tumor entities relates to differences in cellular origin and to de novo epigenetic alterations, which allowed us to build an accurate machine learning-based diagnostic algorithm. We identify extensive individual-specific methylation variability in silenced chromatin associated with the proliferative history of normal and neoplastic B cells. Mitotic activity generally leaves both hyper- and hypomethylation imprints, but some B-cell neoplasms preferentially gain or lose DNA methylation. We construct a DNA-methylation-based mitotic clock, called epiCMIT, whose lapse magnitude represents a strong independent prognostic variable in B-cell tumors and is associated with particular driver genetic alterations. Our findings reveal DNA methylation as a holistic tracer of B-cell tumor developmental history, with implications in differential diagnosis and the prediction of clinical outcome. Martin-Subero and colleagues analyze DNA methylation patterns in B-cell tumors and their normal cells of origin, and develop epiCMIT, a methylation-based mitotic clock with prognostic relevance.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

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