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A pooled analysis o...
A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk
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- Genkinger, Jeanine M. (författare)
- Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA.
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- Spiegelman, Donna (författare)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
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- Anderson, Kristin E. (författare)
- Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.
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- Bernstein, Leslie (författare)
- City Hope Natl Med Ctr, Div Canc Etiol, Duarte, CA 91010 USA.
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- van den Brandt, Piet A. (författare)
- Maastricht Univ, Dept Epidemiol, Sch Oncol & Dev Biol GROW, Maastricht, Netherlands.
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- Calle, Eugenia E. (författare)
- Amer Canc Soc, Atlanta, GA 30329 USA.
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- English, Dallas R. (författare)
- Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.
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- Folsom, Aaron R. (författare)
- Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.
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- Freudenheim, Jo L. (författare)
- SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
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- Fuchs, Charles S. (författare)
- Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.;Harvard Univ, Sch Med, Boston, MA USA.;Dana Farber Canc Inst, Div Med Oncol, Boston, MA 02115 USA.
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- Giles, Graham G. (författare)
- Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.
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- Giovannucci, Edward (författare)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.;Harvard Univ, Sch Med, Boston, MA USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
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- Horn-Ross, Pamela L. (författare)
- No Calif Canc Ctr, Fremont, CA USA.
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- Larsson, Susanna C. (författare)
- Karolinska Institutet
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- Leitzmann, Michael (författare)
- NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.;Univ Regensburg, Inst Epidemiol & Prevent Med, Regensburg, Germany.
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- Mannisto, Satu (författare)
- Natl Inst Hlth & Welf, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland.
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- Marshall, James R. (författare)
- SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
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- Miller, Anthony B. (författare)
- Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
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- Patel, Alpa V. (författare)
- Amer Canc Soc, Atlanta, GA 30329 USA.
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- Rohan, Thomas E. (författare)
- Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
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- Stolzenberg-Solomon, Rachael Z. (författare)
- NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.
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- Verhage, Bas A. J. (författare)
- Maastricht Univ, Dept Epidemiol, Sch Oncol & Dev Biol GROW, Maastricht, Netherlands.
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- Virtamo, Jarmo (författare)
- Natl Inst Hlth & Welf, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland.
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- Willcox, Bradley J. (författare)
- Univ Hawaii, John A Burns Sch Med, Manoa, HI USA.;Okinawa Res Ctr Longev Sci, Okinawa, Japan.;Pacific Hlth Res Inst, Honolulu, HI USA.;Queens Med Ctr, Honolulu, HI USA.
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- Wolk, Alicja (författare)
- Karolinska Institutet
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- Ziegler, Regina G. (författare)
- NCI, Epidemiol & Biostat Program, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.
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- Smith-Warner, Stephanie A. (författare)
- Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
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Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. (creator_code:org_t)
- 2011-03-04
- 2011
- Engelska.
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Ingår i: International Journal of Cancer. - : WILEY. - 0020-7136 .- 1097-0215. ; 129:7, s. 1708-1717
- Relaterad länk:
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https://www.onlineli...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2), pancreatic cancer risk was 47% higher (95% CI:23-75%) among obese (BMI >= 30 kg/m(2)) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI >= 25 kg/m(2) to a BMI between 21 and 22.9 kg/m(2)). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m(2)) and not obese at baseline (BMI < 30 kg/m(2)), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI >= 10 kg/m(2) between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- pancreatic cancer
- anthropometry
- pooled analysis
- deceased
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Genkinger, Jeani ...
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Spiegelman, Donn ...
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Anderson, Kristi ...
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Bernstein, Lesli ...
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van den Brandt, ...
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Calle, Eugenia E ...
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English, Dallas ...
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Folsom, Aaron R.
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Freudenheim, Jo ...
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Fuchs, Charles S ...
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Giles, Graham G.
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Giovannucci, Edw ...
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Horn-Ross, Pamel ...
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Larsson, Susanna ...
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Leitzmann, Micha ...
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Mannisto, Satu
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Marshall, James ...
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Miller, Anthony ...
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Patel, Alpa V.
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Rohan, Thomas E.
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Stolzenberg-Solo ...
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Verhage, Bas A. ...
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Virtamo, Jarmo
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Willcox, Bradley ...
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Wolk, Alicja
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Ziegler, Regina ...
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Smith-Warner, St ...
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