WFRF:(Matthiesen Leif)
Sökning: WFRF:(Matthiesen Leif) > (2005-2009) > Immunology of preec...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03943naa a2200349 4500 | |
| 001 | oai:DiVA.org:liu-29576 | |
| 003 | SwePub | |
| 008 | 091009s2005 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-295762 URI |
| 024 | 7 | a https://doi.org/10.1159/0000879122 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a kap2 swepub-publicationtype |
| 100 | 1 | a Matthiesen, Leif,d 1954-u Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping4 aut0 (Swepub:liu)leima96 |
| 245 | 1 0 | a Immunology of preeclampsia |
| 264 | 1 | a Basel, Switzerland :b S. Karger,c 2005 |
| 338 | a print2 rdacarrier | |
| 520 | a Preeclampsia is a placenta-dependent disorder with both local and systemic anomalies with neonatal and maternal morbidity. It is manifested late in pregnancy, but the onset is during early stages of gestation. The current hypothesis regarding the aetiology of preeclampsia is focused on maladaptation of immune responses and defective trophoblast invasion. Thus, an excessive maternal inflammatory response, perhaps directed against foreign fetal antigens, results in a chain of events including shallow trophoblast invasion, defective spiral artery remodelling, placental infarction and release of pro-inflammatory cytokines and placental fragments in the systemic circulation. During normal pregnancy, trophoblasts interact in the decidua with the unique uterine NK cells, modifying their cytokine repertoire, regulating adhesion molecules and matrix metalloproteinases. The inability of trophoblasts to accomplish these changes might be a critical factor for the onset of preeclampsia. Several cytokines, produced at the maternal-fetal interface, have an impact on trophoblast invasion. It is suggested that deficiency of interleukin-10 may contribute to enhanced inflammatory responses towards the trophoblasts elicited by e.g. tumour necrosis factor-α and interferon-γ. Consequently, trophoblasts subjected to a high rate of apoptosis are hampered in their invasive capacity resulting in defective transformation of spiral arteries, hypoxia, thrombosis and infarction of the placenta. The ensuing infarction of placenta leads to leakage of increasing amounts of placental fragments and cytokines in the maternal circulation and an exaggerated systemic endothelial activation as identified in preeclampsia. So far, treatment of preeclampsia is focused on signs like hypertension, whereas attempts of modifying immune responses may be a possibility in the future. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Berg, Göran,d 1946-u Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping4 aut0 (Swepub:liu)gorbe09 |
| 700 | 1 | a Ernerudh, Jan,d 1952-u Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin4 aut0 (Swepub:liu)janer15 |
| 700 | 1 | a Ekerfelt, Christina,d 1957-u Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut0 (Swepub:liu)chrek55 |
| 700 | 1 | a Jonsson, Yvonne,d 1974-u Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut0 (Swepub:liu)yvojo35 |
| 700 | 1 | a Sharma, Surendrau Department of Pediatrics and Pathology, Women and Infants Hospital of Rhode Island, Brown University, Providence, R.I., USA4 aut |
| 710 | 2 | a Linköpings universitetb Obstetrik och gynekologi4 org |
| 773 | 0 | t Immunology of pregnancyd Basel, Switzerland : S. Kargerg , s. 49-61q <49-61z 9783805579704z 9783318012484 |
| 856 | 4 | u https://libris.kb.se/bib/9991557y Find book at a swedish library/Hitta boken i ett svenskt bibliotek |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-29576 |
| 856 | 4 8 | u https://doi.org/10.1159/000087912 |
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