WFRF:(Michelsen B)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05554naa a2200889 4500 | |
| 001 | oai:gup.ub.gu.se/315981 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:149333497 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3159812 URI |
| 024 | 7 | a https://doi.org/10.1093/rheumatology/keac1742 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1493334972 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nissen, M.4 aut |
| 245 | 1 0 | a The impact of a csDMARD in combination with a TNF inhibitor on drug retention and clinical remission in axial spondylarthritis |
| 264 | c 2022-03-22 | |
| 264 | 1 | b Oxford University Press (OUP),c 2022 |
| 520 | a Objectives Many axial spondylarthritis (axSpA) patients receive a conventional synthetic DMARD (csDMARD) in combination with a TNF inhibitor (TNFi). However, the value of this co-therapy remains unclear. The objectives were to describe the characteristics of axSpA patients initiating a first TNFi as monotherapy compared with co-therapy with csDMARD, to compare one-year TNFi retention and remission rates, and to explore the impact of peripheral arthritis. Methods Data was collected from 13 European registries. One-year outcomes included TNFi retention and hazard ratios (HR) for discontinuation with 95% CIs. Logistic regression was performed with adjusted odds ratios (OR) of achieving remission (Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP < 1.3 and/or BASDAI < 2) and stratified by treatment. Inter-registry heterogeneity was assessed using random-effect meta-analyses, combined results were presented when heterogeneity was not significant. Peripheral arthritis was defined as >= 1 swollen joint at baseline (=TNFi start). Results Amongst 24 171 axSpA patients, 32% received csDMARD co-therapy (range across countries: 13.5% to 71.2%). The co-therapy group had more baseline peripheral arthritis and higher CRP than the monotherapy group. One-year TNFi-retention rates (95% CI): 79% (78, 79%) for TNFi monotherapy vs 82% (81, 83%) with co-therapy (P < 0.001). Remission was obtained in 20% on monotherapy and 22% on co-therapy (P < 0.001); adjusted OR of 1.16 (1.07, 1.25). Remission rates at 12 months were similar in patients with/without peripheral arthritis. Conclusion This large European study of axial SpA patients showed similar one-year treatment outcomes for TNFi monotherapy and csDMARD co-therapy, although considerable heterogeneity across countries limited the identification of certain subgroups (e.g. peripheral arthritis) that may benefit from co-therapy. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
| 653 | a spondylitis | |
| 653 | a ankylosing | |
| 653 | a MTX | |
| 653 | a SSZ | |
| 653 | a TNF inhibitors | |
| 653 | a epidemiology | |
| 653 | a modifying antirheumatic drugs | |
| 653 | a ankylosing-spondylitis | |
| 653 | a rheumatoid-arthritis | |
| 653 | a psoriatic-arthritis | |
| 653 | a treatment response | |
| 653 | a spondyloarthritis | |
| 653 | a comedication | |
| 653 | a infliximab | |
| 653 | a methotrexate | |
| 653 | a survival | |
| 653 | a Rheumatology | |
| 700 | 1 | a Delcoigne, B.u Karolinska Institutet4 aut |
| 700 | 1 | a Di Giuseppe, D.u Karolinska Institutet4 aut |
| 700 | 1 | a Jacobsson, Lennart T. H.,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xjacle |
| 700 | 1 | a Hetland, M. L.4 aut |
| 700 | 1 | a Ciurea, A.4 aut |
| 700 | 1 | a Nekvindova, L.4 aut |
| 700 | 1 | a Iannone, F.4 aut |
| 700 | 1 | a Akkoc, N.4 aut |
| 700 | 1 | a Sokka-Isler, T.4 aut |
| 700 | 1 | a Fagerli, K. M.4 aut |
| 700 | 1 | a Santos, M. J.4 aut |
| 700 | 1 | a Codreanu, C.4 aut |
| 700 | 1 | a Pombo-Suarez, M.4 aut |
| 700 | 1 | a Rotar, Z.4 aut |
| 700 | 1 | a Gudbjornsson, B.4 aut |
| 700 | 1 | a Van der Horst-Bruinsma, I.4 aut |
| 700 | 1 | a Loft, A. G.4 aut |
| 700 | 1 | a Moller, B.4 aut |
| 700 | 1 | a Mann, H.4 aut |
| 700 | 1 | a Conti, F.4 aut |
| 700 | 1 | a Cetin, G. Y.4 aut |
| 700 | 1 | a Relas, H.4 aut |
| 700 | 1 | a Michelsen, B.4 aut |
| 700 | 1 | a Ribeiro, P. A.4 aut |
| 700 | 1 | a Ionescu, R.4 aut |
| 700 | 1 | a Sanchez-Piedra, C.4 aut |
| 700 | 1 | a Tomsic, M.4 aut |
| 700 | 1 | a Geirsson, A. J.u Karolinska Institutet4 aut |
| 700 | 1 | a Askling, J.4 aut |
| 700 | 1 | a Glintborg, B.4 aut |
| 700 | 1 | a Lindström, Ulfu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xlulfn |
| 710 | 2 | a Karolinska Institutetb Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning4 org |
| 773 | 0 | t Rheumatologyd : Oxford University Press (OUP)g 61:12, s. 4741-4751q 61:12<4741-4751x 1462-0324x 1462-0332 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/315981 |
| 856 | 4 8 | u https://doi.org/10.1093/rheumatology/keac174 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:149333497 |
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