An investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.

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An investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.

Peters, Ruth (author)

Yasar, Sevil (author)

Anderson, Craig S (author)

Andrews, Shea (author)

Antikainen, Riitta (author)

Arima, Hisatomi (author)

Beckett, Nigel (author)

Beer, Joanne C (author)

Bertens, Anne Suzanne (author)

Booth, Andrew (author)

van Boxtel, Martin (author)

Brayne, Carol (author)

Brodaty, Henry (author)

Carlson, Michelle C (author)

Chalmers, John (author)

Corrada, Maria (author)

DeKosky, Steven (author)

Derby, Carol (author)

Dixon, Roger A (author)

Forette, Françoise (author)

Ganguli, Mary (author)

van Gool, Willem A (author)

Guaita, Antonio (author)

Hever, Ann M (author)

Hogan, David B (author)

Jagger, Carol (author)

Katz, Mindy (author)

Kawas, Claudia (author)

Kehoe, Patrick G (author)

Keinanen-Kiukaanniemi, Sirkka (author)

Kenny, Rose Ann (author)

Köhler, Sebastian (author)

Kunutsor, Setor K (author)

Laukkanen, Jari (author)

Maxwell, Colleen (author)

McFall, G Peggy (author)

van Middelaar, Tessa (author)

Moll van Charante, Eric P (author)

Ng, Tze-Pin (author)

Peters, Jean (author)

Rawtaer, Iris (author)

Richard, Edo (author)

Rockwood, Kenneth (author)

Rydén, Lina, 1982 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology,Centre for Ageing and Health (Agecap)

Sachdev, Perminder S (author)

Skoog, Ingmar, 1954 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology,Centre for Ageing and Health (Agecap)

Skoog, Johan, 1985 (author): Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Centrum för åldrande och hälsa (AgeCap),Department of Psychology,Centre for Ageing and Health (Agecap)

Staessen, Jan A (author)

Stephan, Blossom C M (author)

Sebert, Sylvain (author)

Thijs, Lutgarde (author)

Trompet, Stella (author)

Tully, Phillip J (author)

Tzourio, Christophe (author)

Vaccaro, Roberta (author)

Vaaramo, Eeva (author)

Walsh, Erin (author)

Warwick, Jane (author)

Anstey, Kaarin J (author)

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(creator_code:org_t)

2020
2020
English.
In: Neurology. - 1526-632X. ; 94:3

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

High blood pressure is one of the main modifiable risk factors for dementia. However, there is conflicting evidence regarding the best antihypertensive class for optimizing cognition. Our objective was to determine whether any particular antihypertensive class was associated with a reduced risk of cognitive decline or dementia using comprehensive meta-analysis including reanalysis of original participant data.To identify suitable studies, MEDLINE, Embase, and PsycINFO and preexisting study consortia were searched from inception to December 2017. Authors of prospective longitudinal human studies or trials of antihypertensives were contacted for data sharing and collaboration. Outcome measures were incident dementia or incident cognitive decline (classified using the reliable change index method). Data were separated into mid and late-life (>65 years) and each antihypertensive class was compared to no treatment and to treatment with other antihypertensives. Meta-analysis was used to synthesize data.Over 50,000 participants from 27 studies were included. Among those aged >65 years, with the exception of diuretics, we found no relationship by class with incident cognitive decline or dementia. Diuretic use was suggestive of benefit in some analyses but results were not consistent across follow-up time, comparator group, and outcome. Limited data precluded meaningful analyses in those ≤65 years of age.Our findings, drawn from the current evidence base, support clinical freedom in the selection of antihypertensive regimens to achieve blood pressure goals.The review was registered with the international prospective register of systematic reviews (PROSPERO), registration number CRD42016045454.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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By the author/editor: Peters, Ruth; Yasar, Sevil; Anderson, Craig ...; Andrews, Shea; Antikainen, Riit ...; Arima, Hisatomi; show more...; Beckett, Nigel; Beer, Joanne C; Bertens, Anne Su ...; Booth, Andrew; van Boxtel, Mart ...; Brayne, Carol; Brodaty, Henry; Carlson, Michell ...; Chalmers, John; Corrada, Maria; DeKosky, Steven; Derby, Carol; Dixon, Roger A; Forette, Françoi ...; Ganguli, Mary; van Gool, Willem ...; Guaita, Antonio; Hever, Ann M; Hogan, David B; Jagger, Carol; Katz, Mindy; Kawas, Claudia; Kehoe, Patrick G; Keinanen-Kiukaan ...; Kenny, Rose Ann; Köhler, Sebastia ...; Kunutsor, Setor ...; Laukkanen, Jari; Maxwell, Colleen; McFall, G Peggy; van Middelaar, T ...; Moll van Charant ...; Ng, Tze-Pin; Peters, Jean; Rawtaer, Iris; Richard, Edo; Rockwood, Kennet ...; Rydén, Lina, 198 ...; Sachdev, Permind ...; Skoog, Ingmar, 1 ...; Skoog, Johan, 19 ...; Staessen, Jan A; Stephan, Blossom ...; Sebert, Sylvain; Thijs, Lutgarde; Trompet, Stella; Tully, Phillip J; Tzourio, Christo ...; Vaccaro, Roberta; Vaaramo, Eeva; Walsh, Erin; Warwick, Jane; Anstey, Kaarin J; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: Neurology

By the university: University of Gothenburg

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