Measurement of specific IgE antibodies to Ses i 1 improves the diagnosis of sesame allergy

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Maruyama, N.Kyoto Univ, Grad Sch Agr, Lab Food Qual Design & Dev, Uji, Kyoto 6110011, Japan. (author)

Measurement of specific IgE antibodies to Ses i 1 improves the diagnosis of sesame allergy

Article/chapterEnglish2016

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2015-12-23
Wiley,2016
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LIBRIS-ID:oai:DiVA.org:uu-276829
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-276829URI
https://doi.org/10.1111/cea.12626DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Background The number of reported cases of allergic reactions to sesame seeds (Sesamum indicum) has increased significantly. The specific IgE tests and skin prick tests presently available for diagnosis of sesame allergy are all based on crude sesame extract and are limited by their low clinical specificity. Thus, oral food challenge (OFC) is still the gold standard in the diagnosis. Objective The aim was to identify the allergen components useful to diagnose sesame-allergic children with the goal to reduce the number of OFCs needed. Methods Ninety-two sesame-sensitized children were consecutively enrolled and diagnosed based on OFC or convincing history. Specific IgE to purified native 11S globulin (nSes i 11S), 7S globulin (nSes i 7S), 2S albumin (nSes i 2S), and two recombinant 2S albumins (rSes i 1 and rSes i 2) was measured by ELISA and/or ImmunoCAP (rSes i 1/streptavidin application). Results Based on area under curve (AUC) values from receiver operating characteristic (ROC) analysis, rSes i 1 was shown to have the best diagnostic performance of the allergen components in ELISA. The experimental rSes i 1 ImmunoCAP test had larger AUC (0.891; 95% CI, 0.826-0.955) compared to the commercially available sesame ImmunoCAP (0.697; 95% CI, 0.589-0.805). The clinical sensitivity and specificity for the rSes i 1 ImmunoCAP test at optimal cut-off (3.96 kUA/L) were 86.1% and 85.7%, respectively. Conclusion and Clinical Relevance Sensitization to Ses i 1 is strongly associated with clinical sesame allergy. Measurement of specific IgE to rSes i 1 could reduce the numbers of OFCs needed.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
2S albumin
molecular-based allergy diagnostics
oral food challenge
Ses i 1
sesame

Added entries (persons, corporate bodies, meetings, titles ...)

Nakagawa, T.Aichi Childrens Hlth & Med Ctr, Dept Allergy, Obu, Aichi, Japan. (author)
Ito, K.Aichi Childrens Hlth & Med Ctr, Dept Allergy, Obu, Aichi, Japan. (author)
Cabanos, C.Kyoto Univ, Grad Sch Agr, Lab Food Qual Design & Dev, Uji, Kyoto 6110011, Japan. (author)
Borres, Magnus P.Uppsala universitet,Pediatrik,Thermo Fisher Sci, Uppsala, Sweden.(Swepub:uu)magbo385 (author)
Moverare, RobertUppsala universitet,Institutionen för medicinska vetenskaper,Thermo Fisher Sci, Uppsala, Sweden.(Swepub:uu)robmo702 (author)
Tanaka, A.Thermo Fisher Sci, Tokyo, Japan. (author)
Sato, S.Sagamihara Natl Hosp, Clin Res Ctr Allergol & Rheumatol, Dept Allergy, Sagamihara, Kanagawa, Japan. (author)
Ebisawa, M.Sagamihara Natl Hosp, Clin Res Ctr Allergol & Rheumatol, Dept Allergy, Sagamihara, Kanagawa, Japan. (author)
Kyoto Univ, Grad Sch Agr, Lab Food Qual Design & Dev, Uji, Kyoto 6110011, Japan.Aichi Childrens Hlth & Med Ctr, Dept Allergy, Obu, Aichi, Japan. (creator_code:org_t)

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In:Clinical and Experimental Allergy: Wiley46:1, s. 163-1710954-78941365-2222

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