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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04085naa a2200445 4500 | |
| 001 | oai:DiVA.org:uu-276829 | |
| 003 | SwePub | |
| 008 | 160216s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2768292 URI |
| 024 | 7 | a https://doi.org/10.1111/cea.126262 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Maruyama, N.u Kyoto Univ, Grad Sch Agr, Lab Food Qual Design & Dev, Uji, Kyoto 6110011, Japan.4 aut |
| 245 | 1 0 | a Measurement of specific IgE antibodies to Ses i 1 improves the diagnosis of sesame allergy |
| 264 | c 2015-12-23 | |
| 264 | 1 | b Wiley,c 2016 |
| 338 | a print2 rdacarrier | |
| 520 | a Background The number of reported cases of allergic reactions to sesame seeds (Sesamum indicum) has increased significantly. The specific IgE tests and skin prick tests presently available for diagnosis of sesame allergy are all based on crude sesame extract and are limited by their low clinical specificity. Thus, oral food challenge (OFC) is still the gold standard in the diagnosis. Objective The aim was to identify the allergen components useful to diagnose sesame-allergic children with the goal to reduce the number of OFCs needed. Methods Ninety-two sesame-sensitized children were consecutively enrolled and diagnosed based on OFC or convincing history. Specific IgE to purified native 11S globulin (nSes i 11S), 7S globulin (nSes i 7S), 2S albumin (nSes i 2S), and two recombinant 2S albumins (rSes i 1 and rSes i 2) was measured by ELISA and/or ImmunoCAP (rSes i 1/streptavidin application). Results Based on area under curve (AUC) values from receiver operating characteristic (ROC) analysis, rSes i 1 was shown to have the best diagnostic performance of the allergen components in ELISA. The experimental rSes i 1 ImmunoCAP test had larger AUC (0.891; 95% CI, 0.826-0.955) compared to the commercially available sesame ImmunoCAP (0.697; 95% CI, 0.589-0.805). The clinical sensitivity and specificity for the rSes i 1 ImmunoCAP test at optimal cut-off (3.96 kUA/L) were 86.1% and 85.7%, respectively. Conclusion and Clinical Relevance Sensitization to Ses i 1 is strongly associated with clinical sesame allergy. Measurement of specific IgE to rSes i 1 could reduce the numbers of OFCs needed. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
| 653 | a 2S albumin | |
| 653 | a molecular-based allergy diagnostics | |
| 653 | a oral food challenge | |
| 653 | a Ses i 1 | |
| 653 | a sesame | |
| 700 | 1 | a Nakagawa, T.u Aichi Childrens Hlth & Med Ctr, Dept Allergy, Obu, Aichi, Japan.4 aut |
| 700 | 1 | a Ito, K.u Aichi Childrens Hlth & Med Ctr, Dept Allergy, Obu, Aichi, Japan.4 aut |
| 700 | 1 | a Cabanos, C.u Kyoto Univ, Grad Sch Agr, Lab Food Qual Design & Dev, Uji, Kyoto 6110011, Japan.4 aut |
| 700 | 1 | a Borres, Magnus P.u Uppsala universitet,Pediatrik,Thermo Fisher Sci, Uppsala, Sweden.4 aut0 (Swepub:uu)magbo385 |
| 700 | 1 | a Moverare, Robertu Uppsala universitet,Institutionen för medicinska vetenskaper,Thermo Fisher Sci, Uppsala, Sweden.4 aut0 (Swepub:uu)robmo702 |
| 700 | 1 | a Tanaka, A.u Thermo Fisher Sci, Tokyo, Japan.4 aut |
| 700 | 1 | a Sato, S.u Sagamihara Natl Hosp, Clin Res Ctr Allergol & Rheumatol, Dept Allergy, Sagamihara, Kanagawa, Japan.4 aut |
| 700 | 1 | a Ebisawa, M.u Sagamihara Natl Hosp, Clin Res Ctr Allergol & Rheumatol, Dept Allergy, Sagamihara, Kanagawa, Japan.4 aut |
| 710 | 2 | a Kyoto Univ, Grad Sch Agr, Lab Food Qual Design & Dev, Uji, Kyoto 6110011, Japan.b Aichi Childrens Hlth & Med Ctr, Dept Allergy, Obu, Aichi, Japan.4 org |
| 773 | 0 | t Clinical and Experimental Allergyd : Wileyg 46:1, s. 163-171q 46:1<163-171x 0954-7894x 1365-2222 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-276829 |
| 856 | 4 8 | u https://doi.org/10.1111/cea.12626 |
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