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An individual patient data meta-analysis to determine cut-offs for and confounders of NAFLD-fibrosis staging with magnetic resonance elastography
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- Liang, Jia-xu (author)
- Virgen del Rocio Univ Hosp, Digest Dis Dept, Ave Manuel Siurot S-N, Seville 41013, Spain.;Virgen del Rocio Univ Hosp, Digest Dis Unit, Seville, Spain.;Virgen del Rocio Univ Hosp, CIBERehd, Seville, Spain.;Univ Seville, Inst Biomed Seville HUVR CSIC US, Seville, Spain.
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- Ampuero, Javier (author)
- Virgen del Rocio Univ Hosp, Digest Dis Dept, Ave Manuel Siurot S-N, Seville 41013, Spain.;Virgen del Rocio Univ Hosp, Digest Dis Unit, Seville, Spain.;Virgen del Rocio Univ Hosp, CIBERehd, Seville, Spain.
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- Niu, Hao (author)
- Henan Univ Chinese Med, Dept Diagnost Radiol, Clin Med Coll 5, Zhengzhou Peoples Hosp, Zhengzhou, Peoples R China.;Univ Malaga, Virgen de la Victoria Univ Hosp, Biomed Res Inst Malaga & Nanomed Platform IBIMA, Digest Syst & Clin Pharmacol Unit, Malaga, Spain.
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- Virgen del Rocio Univ Hosp, Digest Dis Dept, Ave Manuel Siurot S-N, Seville 41013, Spain;Virgen del Rocio Univ Hosp, Digest Dis Unit, Seville, Spain.;Virgen del Rocio Univ Hosp, CIBERehd, Seville, Spain.;Univ Seville, Inst Biomed Seville HUVR CSIC US, Seville, Spain. Virgen del Rocio Univ Hosp, Digest Dis Dept, Ave Manuel Siurot S-N, Seville 41013, Spain.;Virgen del Rocio Univ Hosp, Digest Dis Unit, Seville, Spain.;Virgen del Rocio Univ Hosp, CIBERehd, Seville, Spain. (creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
- In: Journal of Hepatology. - : Elsevier. - 0168-8278 .- 1600-0641. ; 79:3
- Journal article (peer-reviewed)
Abstract
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- Background & Aims: We conducted an individual patient data meta-analysis to establish stiffness cut-off values for magnetic resonance elastography (MRE) in staging liver fibrosis and to assess potential confounding factors. Methods: A systematic review of the literature identified studies reporting MRE data in patients with NAFLD. Data were obtained from the corresponding authors. The pooled diagnostic cut-off value for the various fibrosis stages was determined in a two-stage meta-analysis. Multilevel modelling methods were used to analyse potential confounding factors influencing the diagnostic accuracy of MRE in staging liver fibrosis. Results: Eight independent cohorts comprising 798 patients were included in the meta-analysis. The area under the receiver operating characteristic curve (AUROC) for MRE in detecting significant fibrosis was 0.92 (sensitivity, 79%; specificity, 89%). For advanced fibrosis, the AUROC was 0.92 (sensitivity, 87%; specificity, 88%). For cirrhosis, the AUROC was 0.94 (sensitivity, 88%, specificity, 89%). Cut-offs were defined to explore concordance between MRE and histopathology: 0.05) and high gamma-glutamyl transferase (GGT) concentration ( 120U/L) (odds ratio 3.388, 95% CI 1.577- 7.278, p <0.01] were significantly associated with elevated liver stiffness, and thus affecting accuracy in staging early fibrosis (F0-F1). Steatosis, as measured by magnetic resonance imaging proton density fat fraction, and body mass index(BMI) were not confounders. Conclusions: MRE has excellent diagnostic performance for significant, advanced fibrosis and cirrhosis in patients with NAFLD. Elevated inflammatory activity and GGT level may lead to overestimation of early liver fibrosis, but anthropometric measures such as BMI or the degree of steatosis do not. <(c)> 2023 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Elastography
- Magnetic Resonance
- Fibrosis
- NAFLD
- NASH
- GGT
Publication and Content Type
- ref (subject category)
- art (subject category)
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