Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

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Fältnamn	Indikatorer	Metadata
000		09485naa a2202281 4500
001		oai:DiVA.org:uu-136017
003		SwePub
008		101209s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:e894a89f-634c-424a-9b8f-4eb5fe7a0c1e
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1360172 URI
024	7	a https://doi.org/10.1038/ng.6092 DOI
024	7	a https://lup.lub.lu.se/record/16288032 URI
040		a (SwePub)uud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Voight, Benjamin F.4 aut
245	1 0	a Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
264		c 2010-06-27
264	1	b Springer Science and Business Media LLC,c 2010
338		a print2 rdacarrier
520		a By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P < 5 x 10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng
653		a MEDICINE
653		a MEDICIN
700	1	a Scott, Laura J.4 aut
700	1	a Steinthorsdottir, Valgerdur4 aut
700	1	a Morris, Andrew P.4 aut
700	1	a Dina, Christian4 aut
700	1	a Welch, Ryan P.4 aut
700	1	a Zeggini, Eleftheria4 aut
700	1	a Huth, Cornelia4 aut
700	1	a Aulchenko, Yurii S.4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a McCulloch, Laura J.4 aut
700	1	a Ferreira, Teresa4 aut
700	1	a Grallert, Harald4 aut
700	1	a Amin, Najaf4 aut
700	1	a Wu, Guanming4 aut
700	1	a Willer, Cristen J.4 aut
700	1	a Raychaudhuri, Soumya4 aut
700	1	a McCarroll, Steve A.4 aut
700	1	a Langenberg, Claudia4 aut
700	1	a Hofmann, Oliver M.4 aut
700	1	a Dupuis, Josee4 aut
700	1	a Qi, Lu4 aut
700	1	a Segre, Ayellet V.4 aut
700	1	a van Hoek, Mandy4 aut
700	1	a Navarro, Pau4 aut
700	1	a Ardlie, Kristin4 aut
700	1	a Balkau, Beverley4 aut
700	1	a Benediktsson, Rafn4 aut
700	1	a Bennett, Amanda J.4 aut
700	1	a Blagieva, Roza4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Bonnycastle, Lori L.4 aut
700	1	a Bostrom, Kristina Bengtsson4 aut
700	1	a Bravenboer, Bert4 aut
700	1	a Bumpstead, Suzannah4 aut
700	1	a Burtt, Noisel P.4 aut
700	1	a Charpentier, Guillaume4 aut
700	1	a Chines, Peter S.4 aut
700	1	a Cornelis, Marilyn4 aut
700	1	a Couper, David J.4 aut
700	1	a Crawford, Gabe4 aut
700	1	a Doney, Alex S. F.4 aut
700	1	a Elliott, Katherine S.4 aut
700	1	a Elliott, Amanda L.4 aut
700	1	a Erdos, Michael R.4 aut
700	1	a Fox, Caroline S.4 aut
700	1	a Franklin, Christopher S.4 aut
700	1	a Ganser, Martha4 aut
700	1	a Gieger, Christian4 aut
700	1	a Grarup, Niels4 aut
700	1	a Green, Todd4 aut
700	1	a Griffin, Simon4 aut
700	1	a Groves, Christopher J.4 aut
700	1	a Guiducci, Candace4 aut
700	1	a Hadjadj, Samy4 aut
700	1	a Hassanali, Neelam4 aut
700	1	a Herder, Christian4 aut
700	1	a Isomaa, Bo4 aut
700	1	a Jackson, Anne U.4 aut
700	1	a Johnson, Paul R. V.4 aut
700	1	a Jorgensen, Torben4 aut
700	1	a Kao, Wen H. L.4 aut
700	1	a Klopp, Norman4 aut
700	1	a Kong, Augustine4 aut
700	1	a Kraft, Peter4 aut
700	1	a Kuusisto, Johanna4 aut
700	1	a Lauritzen, Torsten4 aut
700	1	a Li, Man4 aut
700	1	a Lieverse, Aloysius4 aut
700	1	a Lindgren, Cecilia M.4 aut
700	1	a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly
700	1	a Marre, Michel4 aut
700	1	a Meitinger, Thomas4 aut
700	1	a Midthjell, Kristian4 aut
700	1	a Morken, Mario A.4 aut
700	1	a Narisu, Narisu4 aut
700	1	a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni
700	1	a Owen, Katharine R.4 aut
700	1	a Payne, Felicity4 aut
700	1	a Perry, John R. B.4 aut
700	1	a Petersen, Ann-Kristin4 aut
700	1	a Platou, Carl4 aut
700	1	a Proenca, Christine4 aut
700	1	a Prokopenko, Inga4 aut
700	1	a Rathmann, Wolfgang4 aut
700	1	a Rayner, N. William4 aut
700	1	a Robertson, Neil R.4 aut
700	1	a Rocheleau, Ghislain4 aut
700	1	a Roden, Michael4 aut
700	1	a Sampson, Michael J.4 aut
700	1	a Saxena, Richa4 aut
700	1	a Shields, Beverley M.4 aut
700	1	a Shrader, Peter4 aut
700	1	a Sigurdsson, Gunnar4 aut
700	1	a Sparso, Thomas4 aut
700	1	a Strassburger, Klaus4 aut
700	1	a Stringham, Heather M.4 aut
700	1	a Sun, Qi4 aut
700	1	a Swift, Amy J.4 aut
700	1	a Thorand, Barbara4 aut
700	1	a Tichet, Jean4 aut
700	1	a Tuomi, Tiinamaija4 aut
700	1	a van Dam, Rob M.4 aut
700	1	a van Haeften, Timon W.4 aut
700	1	a van Herpt, Thijs4 aut
700	1	a van Vliet-Ostaptchouk, Jana V.4 aut
700	1	a Walters, G. Bragi4 aut
700	1	a Weedon, Michael N.4 aut
700	1	a Wijmenga, Cisca4 aut
700	1	a Witteman, Jacqueline4 aut
700	1	a Bergman, Richard N.4 aut
700	1	a Cauchi, Stephane4 aut
700	1	a Collins, Francis S.4 aut
700	1	a Gloyn, Anna L.4 aut
700	1	a Gyllensten, Ulfu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)ulfgyll
700	1	a Hansen, Torben4 aut
700	1	a Hide, Winston A.4 aut
700	1	a Hitman, Graham A.4 aut
700	1	a Hofman, Albert4 aut
700	1	a Hunter, David J.4 aut
700	1	a Hveem, Kristian4 aut
700	1	a Laakso, Markku4 aut
700	1	a Mohlke, Karen L.4 aut
700	1	a Morris, Andrew D.4 aut
700	1	a Palmer, Colin N. A.4 aut
700	1	a Pramstaller, Peter P.4 aut
700	1	a Rudan, Igor4 aut
700	1	a Sijbrands, Eric4 aut
700	1	a Stein, Lincoln D.4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a Uitterlinden, Andre4 aut
700	1	a Walker, Mark4 aut
700	1	a Wareham, Nicholas J.4 aut
700	1	a Watanabe, Richard M.4 aut
700	1	a Abecasis, Goncalo R.4 aut
700	1	a Boehm, Bernhard O.4 aut
700	1	a Campbell, Harry4 aut
700	1	a Daly, Mark J.4 aut
700	1	a Hattersley, Andrew T.4 aut
700	1	a Hu, Frank B.4 aut
700	1	a Meigs, James B.4 aut
700	1	a Pankow, James S.4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a Barroso, Ines4 aut
700	1	a Florez, Jose C.4 aut
700	1	a Frayling, Timothy M.4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Sladek, Rob4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Wilson, James F.4 aut
700	1	a Illig, Thomas4 aut
700	1	a Froguel, Philippe4 aut
700	1	a van Duijn, Cornelia M.4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Altshuler, David4 aut
700	1	a Boehnke, Michael4 aut
700	1	a McCarthy, Mark I.4 aut
710	2	a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 42:7, s. 579-589q 42:7<579-589x 1061-4036x 1546-1718
856	4	u https://cdr.lib.unc.edu/downloads/f1881v03m
856	4	u http://dx.doi.org/10.1038/ng.609y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-136017
856	4 8	u https://doi.org/10.1038/ng.609
856	4 8	u https://lup.lub.lu.se/record/1628803

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Av författaren/redakt...: Voight, Benjamin ...; Scott, Laura J.; Steinthorsdottir ...; Morris, Andrew P ...; Dina, Christian; Welch, Ryan P.; visa fler...; Zeggini, Elefthe ...; Huth, Cornelia; Aulchenko, Yurii ...; Thorleifsson, Gu ...; McCulloch, Laura ...; Ferreira, Teresa; Grallert, Harald; Amin, Najaf; Wu, Guanming; Willer, Cristen ...; Raychaudhuri, So ...; McCarroll, Steve ...; Langenberg, Clau ...; Hofmann, Oliver ...; Dupuis, Josee; Qi, Lu; Segre, Ayellet V ...; van Hoek, Mandy; Navarro, Pau; Ardlie, Kristin; Balkau, Beverley; Benediktsson, Ra ...; Bennett, Amanda ...; Blagieva, Roza; Boerwinkle, Eric; Bonnycastle, Lor ...; Bostrom, Kristin ...; Bravenboer, Bert; Bumpstead, Suzan ...; Burtt, Noisel P.; Charpentier, Gui ...; Chines, Peter S.; Cornelis, Marily ...; Couper, David J.; Crawford, Gabe; Doney, Alex S. F ...; Elliott, Katheri ...; Elliott, Amanda ...; Erdos, Michael R ...; Fox, Caroline S.; Franklin, Christ ...; Ganser, Martha; Gieger, Christia ...; Grarup, Niels; Green, Todd; Griffin, Simon; Groves, Christop ...; Guiducci, Candac ...; Hadjadj, Samy; Hassanali, Neela ...; Herder, Christia ...; Isomaa, Bo; Jackson, Anne U.; Johnson, Paul R. ...; Jorgensen, Torbe ...; Kao, Wen H. L.; Klopp, Norman; Kong, Augustine; Kraft, Peter; Kuusisto, Johann ...; Lauritzen, Torst ...; Li, Man; Lieverse, Aloysi ...; Lindgren, Cecili ...; Lyssenko, Valeri ...; Marre, Michel; Meitinger, Thoma ...; Midthjell, Krist ...; Morken, Mario A.; Narisu, Narisu; Nilsson, Peter; Owen, Katharine ...; Payne, Felicity; Perry, John R. B ...; Petersen, Ann-Kr ...; Platou, Carl; Proenca, Christi ...; Prokopenko, Inga; Rathmann, Wolfga ...; Rayner, N. Willi ...; Robertson, Neil ...; Rocheleau, Ghisl ...; Roden, Michael; Sampson, Michael ...; Saxena, Richa; Shields, Beverle ...; Shrader, Peter; Sigurdsson, Gunn ...; Sparso, Thomas; Strassburger, Kl ...; Stringham, Heath ...; Sun, Qi; Swift, Amy J.; Thorand, Barbara; Tichet, Jean; Tuomi, Tiinamaij ...; van Dam, Rob M.; van Haeften, Tim ...; van Herpt, Thijs; van Vliet-Ostapt ...; Walters, G. Brag ...; Weedon, Michael ...; Wijmenga, Cisca; Witteman, Jacque ...; Bergman, Richard ...; Cauchi, Stephane; Collins, Francis ...; Gloyn, Anna L.; Gyllensten, Ulf; Hansen, Torben; Hide, Winston A.; Hitman, Graham A ...; Hofman, Albert; Hunter, David J.; Hveem, Kristian; Laakso, Markku; Mohlke, Karen L.; Morris, Andrew D ...; Palmer, Colin N. ...; Pramstaller, Pet ...; Rudan, Igor; Sijbrands, Eric; Stein, Lincoln D ...; Tuomilehto, Jaak ...; Uitterlinden, An ...; Walker, Mark; Wareham, Nichola ...; Watanabe, Richar ...; Abecasis, Goncal ...; Boehm, Bernhard ...; Campbell, Harry; Daly, Mark J.; Hattersley, Andr ...; Hu, Frank B.; Meigs, James B.; Pankow, James S.; Pedersen, Oluf; Wichmann, H-Eric ...; Barroso, Ines; Florez, Jose C.; Frayling, Timoth ...; Groop, Leif; Sladek, Rob; Thorsteinsdottir ...; Wilson, James F.; Illig, Thomas; Froguel, Philipp ...; van Duijn, Corne ...; Stefansson, Kari; Altshuler, David; Boehnke, Michael; McCarthy, Mark I ...; visa färre...

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