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Sökning: WFRF:(Ninerola Baizan A.) > Reactive astroglios...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005158naa a2200745 4500
001oai:gup.ub.gu.se/317777
003SwePub
008240910s2022 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3177772 URI
0247 a https://doi.org/10.1007/s00259-022-05897-42 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Salvado, G.4 aut
2451 0a Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's continuum
264 c 2022-07-18
264 1b Springer Science and Business Media LLC,c 2022
520 a Purpose Glial activation is one of the earliest mechanisms to be altered in Alzheimer's disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be measured in both cerebrospinal fluid (CSF) and blood. Plasma GFAP has been suggested to become altered earlier in AD than its CSF counterpart. Although astrocytes consume approximately half of the glucose-derived energy in the brain, the relationship between reactive astrogliosis and cerebral glucose metabolism is poorly understood. Here, we aimed to investigate the association between fluorodeoxyglucose ([F-18]FDG) uptake and reactive astrogliosis, by means of GFAP quantified in both plasma and CSF for the same participants. Methods We included 314 cognitively unimpaired participants from the ALFA + cohort, 112 of whom were amyloid-beta (A beta) positive. Associations between GFAP markers and [F-18]FDG uptake were studied. We also investigated whether these associations were modified by A beta and tau status (AT stages). Results Plasma GFAP was positively associated with glucose consumption in the whole brain, while CSF GFAP associations with [F-18]FDG uptake were only observed in specific smaller areas like temporal pole and superior temporal lobe. These associations persisted when accounting for biomarkers of A beta pathology but became negative in A beta-positive and tau-positive participants (A + T +) in similar areas of AD-related hypometabolism. Conclusions Higher astrocytic reactivity, probably in response to early AD pathological changes, is related to higher glucose consumption. With the onset of tau pathology, the observed uncoupling between astrocytic biomarkers and glucose consumption might be indicative of a failure to sustain the higher energetic demands required by reactive astrocytes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
653 a Glia
653 a Gliosis
653 a Astroglia
653 a Reactive astrocyte
653 a Glucose metabolism
653 a Glucose consumption
653 a energy-metabolism
653 a amyloid-pet
653 a brain
653 a astrocytes
653 a disease
653 a plasma
653 a neuroinflammation
653 a neurons
653 a protein
653 a signal
653 a Radiology
653 a Nuclear Medicine & Medical Imaging
7001 a Mila-Aloma, M.4 aut
7001 a Shekari, M.4 aut
7001 a Ashton, Nicholas J.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xashtn
7001 a Operto, G.4 aut
7001 a Falcon, C.4 aut
7001 a Cacciaglia, R.4 aut
7001 a Minguillon, C.4 aut
7001 a Fauria, K.4 aut
7001 a Ninerola-Baizan, A.4 aut
7001 a Perissinotti, A.4 aut
7001 a Lessa Benedet, Andréau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlesan
7001 a Kollmorgen, G.4 aut
7001 a Suridjan, I.4 aut
7001 a Wild, N.4 aut
7001 a Molinuevo, J. L.4 aut
7001 a Zetterberg, Henrik,d 19734 aut
7001 a Blennow, Kaj,d 19584 aut
7001 a Suarez-Calvet, M.4 aut
7001 a Gispert, J. D.4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
7730 t European Journal of Nuclear Medicine and Molecular Imagingd : Springer Science and Business Media LLCg 49, s. 4567-4579q 49<4567-4579x 1619-7070x 1619-7089
8564 8u https://gup.ub.gu.se/publication/317777
8564 8u https://doi.org/10.1007/s00259-022-05897-4

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