Sökning: WFRF:(Nordström Birgitta) > Small molecule inhi...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04155naa a2200673 4500 | |
001 | oai:DiVA.org:umu-12890 | |
003 | SwePub | |
008 | 080121s2007 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:12017254 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128902 URI |
024 | 7 | a https://doi.org/10.1016/j.febslet.2007.01.0132 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:120172542 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bailey, Leslieu Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström4 aut0 (Swepub:umu)leba0001 |
245 | 1 0 | a Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle |
264 | c 2007-01-17 | |
264 | 1 | b Elsevier,c 2007 |
338 | a print2 rdacarrier | |
520 | a Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re-differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaldehydes that specifically blocks the T3SS of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlamydia. Our results suggest a previously unexplored avenue for development of novel anti-chlamydial drugs. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a Animals | |
653 | a Anti-Bacterial Agents/chemistry/*pharmacology | |
653 | a Bacterial Proteins/*antagonists & inhibitors/genetics/*secretion | |
653 | a Cell Proliferation/drug effects | |
653 | a Chlamydia Infections/*microbiology | |
653 | a Chlamydia trachomatis/cytology/drug effects | |
653 | a Chlamydophila pneumoniae/cytology/*drug effects | |
653 | a Dose-Response Relationship; Drug | |
653 | a Down-Regulation/drug effects | |
653 | a Epithelial Cells/cytology/drug effects/microbiology | |
653 | a Gene Expression Regulation; Bacterial/drug effects | |
653 | a Genes; Bacterial | |
653 | a Hela Cells | |
653 | a Humans | |
653 | a Mice | |
653 | a Transcription; Genetic/drug effects | |
653 | a Yersinia Infections | |
653 | a Yersinia pseudotuberculosis/*drug effects | |
700 | 1 | a Gylfe, Åsau Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström4 aut |
700 | 1 | a Sundin, Charlotta4 aut |
700 | 1 | a Muschiol, Sandrau Karolinska Institutet4 aut |
700 | 1 | a Elofsson, Mikaelu Umeå universitet,Kemiska institutionen,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)4 aut0 (Swepub:umu)miel0001 |
700 | 1 | a Nordström, Peteru Umeå universitet,Medicin4 aut0 (Swepub:umu)peno0014 |
700 | 1 | a Henriques-Normark, Birgittau Karolinska Institutet4 aut |
700 | 1 | a Lugert, Raimond4 aut |
700 | 1 | a Waldenström, Andersu Umeå universitet,Medicin4 aut0 (Swepub:umu)anwa0002 |
700 | 1 | a Wolf-Watz, Hansu Wolf-Watz4 aut0 (Swepub:umu)hawo0001 |
700 | 1 | a Bergström, Svenu Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström4 aut0 (Swepub:umu)svbe0001 |
710 | 2 | a Umeå universitetb Institutionen för molekylärbiologi (Medicinska fakulteten)4 org |
773 | 0 | t FEBS Lettersd : Elsevierg 581:4, s. 587-595q 581:4<587-595x 0014-5793x 1873-3468 |
856 | 4 | u https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2007.01.013 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-12890 |
856 | 4 8 | u https://doi.org/10.1016/j.febslet.2007.01.013 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:12017254 |
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