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Angiotensin II rece...
Angiotensin II receptor expression following intestinal transplantation in mice.
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- Spak, Emma, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Ewert, Sara, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Vieth, Michael (författare)
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- Fändriks, Lars, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Åneman, Anders, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Olausson, Michael, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Dindelegan, George (författare)
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- Engelska.
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Ingår i: The Journal of surgical research. - : Elsevier BV. - 0022-4804. ; 135:1, s. 144-9
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: To further improve the success rate of intestinal transplantation there is a need to find early appearing indicators of rejection. The specific aim of this study was to compare Angiotensin (Ang) II type 1 receptor and Ang II type 2 receptor expression in relation to histological signs of rejection. METHODS: Mice of the C57BL6 strain with syngeneic intestinal grafts were compared to mice subjected to allogeneic intestinal transplantation with BalbC strain as donors. Local expression of Ang II type 1 and 2 receptor was evaluated using rt-PCR and Western blot and compared to histological picture in grafts and native intestine. RESULTS: The Ang II type 2 receptor protein expression was markedly up-regulated in the allogeneically transplanted graft from day 1 postoperatively. Histological signs of rejection were not seen until day 6. CONCLUSION: Intestinal allograft transplantation in mice is associated with a marked up-regulation of the Ang II type 2 receptor. However, the detailed role of the renin-angiotensin system in the immune rejection following intestinal transplantation remains to be clarified.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Animals
- Blotting
- Western
- Gene Expression
- Graft Rejection
- pathology
- physiopathology
- Graft Survival
- physiology
- Jejunum
- pathology
- physiology
- transplantation
- Male
- Mice
- Mice
- Inbred BALB C
- Mice
- Inbred C57BL
- Receptor
- Angiotensin
- Type 1
- genetics
- metabolism
- Receptor
- Angiotensin
- Type 2
- genetics
- metabolism
- Renin-Angiotensin System
- physiology
- Reverse Transcriptase Polymerase Chain Reaction
- Up-Regulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Spak, Emma, 1977
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Ewert, Sara, 197 ...
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Vieth, Michael
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Fändriks, Lars, ...
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Åneman, Anders, ...
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Olausson, Michae ...
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visa fler...
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Dindelegan, Geor ...
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visa färre...
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Göteborgs universitet