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Sökning: WFRF:(Persson H.) > (2020-2024) > A federated approac...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006275naa a2200661 4500
001oai:gup.ub.gu.se/330768
003SwePub
008240528s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:153315869
009oai:lup.lub.lu.se:f71357f7-3b7c-4fa3-af1a-f76009efe00a
0247 a https://gup.ub.gu.se/publication/3307682 URI
0247 a https://doi.org/10.1016/j.ejca.2023.02.0212 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1533158692 URI
0247 a https://lup.lub.lu.se/record/f71357f7-3b7c-4fa3-af1a-f76009efe00a2 URI
040 a (SwePub)gud (SwePub)kid (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wenzel, H. H. B.u University Medical Center Groningen,Netherlands Comprehensive Cancer Organisation (IKNL)4 aut
2451 0a A federated approach to identify women with early-stage cervical cancer at low risk of lymph node metastases
264 1b Elsevier BV,c 2023
520 a Objective: Lymph node metastases (pN+) in presumed early-stage cervical cancer negatively impact prognosis. Using federated learning, we aimed to develop a tool to identify a group of women at low risk of pN+, to guide the shared decision-making process concerning the extent of lymph node dissection.Methods: Women with cervical cancer between 2005 and 2020 were identified retrospectively from population-based registries: the Danish Gynaecological Cancer Database, Swedish Quality Registry for Gynaecologic Cancer and Netherlands Cancer Registry. Inclusion cri-teria were: squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma; The International Federation of Gynecology and Obstetrics 2009 IA2, IB1 and IIA1; treatment with radical hysterectomy and pelvic lymph node assessment. We applied privacy-preserving federated logistic regression to identify risk factors of pN+. Significant factors were used to stratify the risk of pN+. Results: We included 3606 women (pN+ 11%). The most important risk factors of pN+ were lymphovascular space invasion (LVSI) (odds ratio [OR] 5.16, 95% confidence interval [CI], 4.59-5.79), tumour size 21-40 mm (OR 2.14, 95% CI, 1.89-2.43) and depth of invasion > 10 mm (OR 1.81, 95% CI, 1.59-2.08). A group of 1469 women (41%)-with tumours without LVSI, tumour size 520 mm, and depth of invasion 510 mm-had a very low risk of pN + (2.4%, 95% CI, 1.7-3.3%). Conclusion: Early-stage cervical cancer without LVSI, a tumour size 520 mm and depth of invasion 510 mm, confers a low risk of pN+. Based on an international privacy-preserving analysis, we developed a useful tool to guide the shared decision-making process regarding lymph node dissection.& COPY; 2023 Elsevier Ltd. All rights reserved.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Cervical cancer
653 a Federated learning
653 a Lymph node metastases
653 a Risk factors
653 a tumor size
653 a Oncology
7001 a Hardie, A. N.u Karolinska Institutet,Karolinska University Hospital4 aut
7001 a Moncada-Torres, A.u Netherlands Comprehensive Cancer Organisation (IKNL)4 aut
7001 a Hogdall, C. K.u University of Copenhagen4 aut
7001 a Bekkers, R. L. M.u Maastricht University,Catharina Hospital4 aut
7001 a Falconer, H.u Karolinska Institutet,Karolinska University Hospital4 aut
7001 a Jensen, P. T.u University of Southern Denmark,Aarhus University Hospital4 aut
7001 a Nijman, H. W.u University Medical Center Groningen4 aut
7001 a van der Aa, M. A.u Netherlands Comprehensive Cancer Organisation (IKNL),Odense University Hospital4 aut
7001 a Martin, F.u Netherlands Comprehensive Cancer Organisation (IKNL)4 aut
7001 a van Gestel, A. J.u Netherlands Comprehensive Cancer Organisation (IKNL)4 aut
7001 a Lemmens, Vepp4 aut
7001 a Dahm-Kähler, Pernilla,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Sahlgrenska University Hospital4 aut0 (Swepub:gu)xdahmp
7001 a Alfonzo, Emiliau Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Sahlgrenska University Hospital4 aut0 (Swepub:gu)xalfem
7001 a Persson, Janu Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Livmoder och livmoderhalscancer,Forskargrupper vid Lunds universitet,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Endometrial and cervical cancer,Lund University Research Groups4 aut0 (Swepub:lu)gyn-jpe
7001 a Ekdahl, Linneau Lund University,Lunds universitet,Livmoder och livmoderhalscancer,Forskargrupper vid Lunds universitet,Endometrial and cervical cancer,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)li6714ek
7001 a Salehi, S.u Karolinska Institutet,Karolinska University Hospital4 aut
7001 a Froding, L. P.u Copenhagen University Hospital4 aut
7001 a Markauskas, A.4 aut
7001 a Fuglsang, K.u Aarhus University Hospital4 aut
7001 a Schnack, T. H.u University of Copenhagen,Odense University Hospital4 aut
7102 a University Medical Center Groningenb Netherlands Comprehensive Cancer Organisation (IKNL)4 org
7730 t European Journal of Cancerd : Elsevier BVg 185, s. 61-68q 185<61-68x 0959-8049x 1879-0852
8564 u http://dx.doi.org/10.1016/j.ejca.2023.02.021y FULLTEXT
8564 8u https://gup.ub.gu.se/publication/330768
8564 8u https://doi.org/10.1016/j.ejca.2023.02.021
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:153315869
8564 8u https://lup.lub.lu.se/record/f71357f7-3b7c-4fa3-af1a-f76009efe00a

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