Sökning: WFRF:(Phelan A) > (2020-2024) > Plaque contact and ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03544naa a2200433 4500 | |
001 | oai:gup.ub.gu.se/323348 | |
003 | SwePub | |
008 | 240910s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3233482 URI |
024 | 7 | a https://doi.org/10.1016/j.celrep.2022.1116862 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Wood, Jack,d 1997u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xwooja |
245 | 1 0 | a Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology |
264 | 1 | b Elsevier BV,c 2022 |
520 | a Using spatial cell-type-enriched transcriptomics, we compare plaque-induced gene (PIG) expression in mi-croglia-touching plaques, neighboring plaques, and far from plaques in an aged Alzheimer's mouse model with late plaque development. In 18-month-old APPNL-F/NL-F knockin mice, with and without the Alzheimer's disease risk mutation Trem2R47H/R47H, we report that expression of 38/55 PIGs have plaque-induced micro-glial upregulation, with a subset only upregulating in microglia directly contacting plaques. For seven PIGs, including Trem2, this upregulation is prevented in APPNL-F/NL-FTrem2R47H/R47H mice. These TREM2-depen-dent genes are all involved in phagocytic and degradative processes that we show correspond to a decrease in phagocytic markers and an increase in the density of small plaques in Trem2-mutated mice. Furthermore, despite the R47H mutation preventing increased Trem2 gene expression, TREM2 protein levels and micro-glial density are still marginally increased on plaques. Hence, both microglial contact with plaques and func-tioning TREM2 are necessary for microglia to respond appropriately to amyloid pathology. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
700 | 1 | a Wong, E.4 aut |
700 | 1 | a Joghee, R.4 aut |
700 | 1 | a Balbaa, A.4 aut |
700 | 1 | a Vitanova, K. S.4 aut |
700 | 1 | a Stringer, Katieu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xstrkt |
700 | 1 | a Vanshoiack, A.4 aut |
700 | 1 | a Phelan, S. L. J.4 aut |
700 | 1 | a Launchbury, F.4 aut |
700 | 1 | a Desai, S.4 aut |
700 | 1 | a Tripathi, T.4 aut |
700 | 1 | a Hanrieder, Jörg,d 1980u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xhanrj |
700 | 1 | a Cummings, D. M.4 aut |
700 | 1 | a Hardy, J.4 aut |
700 | 1 | a Edwards, F. A.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Cell Reportsd : Elsevier BVg 41:8q 41:8x 2211-1247 |
856 | 4 8 | u https://gup.ub.gu.se/publication/323348 |
856 | 4 8 | u https://doi.org/10.1016/j.celrep.2022.111686 |
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