WFRF:(Pietschmann Thomas)
Search: WFRF:(Pietschmann Thomas) > (2015-2019) > Decoding protein ne...
- 6 of 9
- Previous record
- Next record
- To hitlist
Decoding protein networks during virus entry by quantitative proteomics
-
- Gerold, Gisa, 1979- (author)
- Insitute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, A joint Venture Between the Medical School Hannover and the Helmholtz Centre for Infection Research, 30652 Hannover, Germany,Gisa Gerold
- Bruening, Janina (author)
- Pietschmann, Thomas (author)
- (creator_code:org_t)
- Elsevier, 2016
- 2016
- English.
- In: Virus Research. - : Elsevier. - 0168-1702 .- 1872-7492. ; 218, s. 25-39
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Virus entry into host cells relies on interactions between viral and host structures including lipids, carbohydrates and proteins. Particularly, protein-protein interactions between viral surface proteins and host proteins as well as secondary host protein-protein interactions play a pivotal role in coordinating virus binding and uptake. These interactions are dynamic and frequently involve multiprotein complexes. In the past decade mass spectrometry based proteomics methods have reached sensitivities and high throughput compatibilities of genomics methods and now allow the reliable quantitation of proteins in complex samples from limited material. As proteomics provides essential information on the biologically active entity namely the protein, including its posttranslational modifications and its interactions with other proteins, it is an indispensable method in the virologist's toolbox. Here we review protein interactions during virus entry and compare classical biochemical methods to study entry with novel technically advanced quantitative proteomics techniques. We highlight the value of quantitative proteomics in mapping functional virus entry networks, discuss the benefits and limitations and illustrate how the methodology will help resolve unsettled questions in virus entry research in the future.
Keyword
- Protein interaction networks
- Protein–protein interactions
- Quantitative proteomics
- Virus entry
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Virus Research (Search for host publication in LIBRIS)
To the university's database
- 6 of 9
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Gerold, Gisa, 19 ...
- Bruening, Janina
- Pietschmann, Tho ...
- Articles in the publication
- Virus Research
- By the university
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
