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Role of smoking in ...
Role of smoking in functional dyspepsia and irritable bowel syndrome : three random population-based studies
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- Talley, Nicholas J. (author)
- Faculty of Health and Medicine, University of Newcastle, Lot 1 Kookaburra Circuit, New Lambton Heights, Australia; NHMRC Centre for Research Excellence in Digestive Health, Australia,Univ Newcastle, Fac Hlth & Med, Lot 1 Kookaburra Circuit, New Lambton Hts 2305, Australia.;NHMRC Ctr Res Excellence Digest Hlth, New Lambton Hts, NSW, Australia.
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- Powell, Nicholas (author)
- Division of Digestive Disease, Imperial College, London, United Kingdom,Imperial Coll, Div Digest Dis, London, England.
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- Walker, Marjorie M. (author)
- Faculty of Health and Medicine, University of Newcastle, Lot 1 Kookaburra Circuit, New Lambton Heights, Australia; NHMRC Centre for Research Excellence in Digestive Health, Australia,Univ Newcastle, Fac Hlth & Med, Lot 1 Kookaburra Circuit, New Lambton Hts 2305, Australia.;NHMRC Ctr Res Excellence Digest Hlth, New Lambton Hts, NSW, Australia.
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- Jones, Mike P. (author)
- NHMRC Centre for Research Excellence in Digestive Health, Australia; Department of Psychology, Macquarie University, NSW, North Ryde, Australia,NHMRC Ctr Res Excellence Digest Hlth, New Lambton Hts, NSW, Australia.;Macquarie Univ, Dept Psychol, N Ryde, NSW, Australia.
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- Ronkainen, Jukka (author)
- Center for Life Course Health Research, University of Oulu, Oulu, Finland; Primary Health Care Centre, Tornio, Finland,Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland.;Primary Hlth Care Ctr, Tornio, Finland.
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- Forsberg, Anna (author)
- Karolinska Institutet
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- Kjellström, Lars (author)
- Gastromottagningen City, Stockholm, Sweden.
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- Hellström, Per M., 1954- (author)
- Uppsala universitet,Gastroenterologi/hepatologi
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- Aro, Pertti (author)
- Arokero OY, Tornio, Finland.
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- Wallner, Bengt, 1962- (author)
- Umeå universitet,Kirurgi,Umeå Univ, Dept Surg & Perioperatve Sci, Umeå, Sweden.
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- Agréus, Lars (author)
- Karolinska Institutet
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- Andreasson, Anna (author)
- Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Macquarie University, Australia; Karolinska Institutet, Sweden,Macquarie Univ, Dept Psychol, N Ryde, NSW, Australia.;Karolinska Inst, Dept Med Solna, Solna, Sweden.;Stockholm Univ, Stress Res Inst, Dept Psychol, Stockholm, Sweden.
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Faculty of Health and Medicine, University of Newcastle, Lot 1 Kookaburra Circuit, New Lambton Heights, Australia; NHMRC Centre for Research Excellence in Digestive Health, Australia Univ Newcastle, Fac Hlth & Med, Lot 1 Kookaburra Circuit, New Lambton Hts 2305, Australia;NHMRC Ctr Res Excellence Digest Hlth, New Lambton Hts, NSW, Australia. (creator_code:org_t)
- 2021-05-13
- 2021
- English.
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In: Alimentary Pharmacology and Therapeutics. - : John Wiley & Sons. - 0269-2813 .- 1365-2036. ; 54:1, s. 32-42
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Abstract
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- Background: It is uncertain if functional dyspepsia (FD) or irritable bowel syndrome (IBS) are linked to smoking, and smoking cessation is not part of the routine advice provided to these patients.Aim: To assess if smoking is an independent risk factor for FD and IBS.Methods: Three population-based endoscopy studies in Sweden with 2560 community individuals in total (mean age 51.5 years, 46% male). IBS (14.9%), FD (33.5%), and associated symptoms were assessed using the validated abdominal symptom questionnaire, and smoking (17.9%) was obtained from standardised questions during a clinic visit. The effect of smoking on symptom status was analysed in an individual person data meta-analysis using mixed effect logistic regression, adjusted for snuffing, age and sex.Results: Individuals smoking cigarettes reported significantly higher odds of postprandial distress syndrome (FD-PDS) (OR 10-19 cig/day = 1.42, 95% CI 1.04-1.98 P = 0.027, OR ≥20 cig/day = 2.16, 95% CI 1.38-3.38, P = 0.001) but not epigastric pain. Individuals smoking 20 or more cigarettes per day reported significantly higher odds of IBS-diarrhoea (OR = 2.40, 95% CI 1.12-5.16, P = 0.025), diarrhoea (OR = 2.01, 95%CI 1.28-3.16, P = 0.003), urgency (OR = 2.21, 95%CI 1.41-3.47, P = 0.001) and flatus (OR = 1.77, 95%CI 1.14-2.76, P = 0.012) than non-smokers. Smoking was not associated with IBS-constipation or IBS-mixed.Conclusion: Smoking is an important environmental risk factor for postprandial distress syndrome, the most common FD subgroup, with over a twofold increased odds of PDS in heavy smokers. The role of smoking in IBS-diarrhoea, but not constipation, is also likely important.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
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- art (subject category)
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Talley, Nicholas ...
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Powell, Nicholas
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Walker, Marjorie ...
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Jones, Mike P.
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Ronkainen, Jukka
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Forsberg, Anna
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Kjellström, Lars
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Hellström, Per M ...
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Aro, Pertti
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Wallner, Bengt, ...
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Agréus, Lars
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Andreasson, Anna
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- MEDICAL AND HEALTH SCIENCES
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Alimentary Pharm ...
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Umeå University
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Stockholm University
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Uppsala University
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Karolinska Institutet