WFRF:(Qian W.)
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Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease : Pooled De Novo Results From 15 Observational Studies
- Laguzzi, F. (author)
-
- Åkesson, A. (author)
- Karolinska Institutet
-
- Marklund, Matti (author)
- Uppsala universitet,Klinisk nutrition och metabolism
- show more...
- Qian, F. (author)
- Bartz, T. M. (author)
- Bassett, J. K. (author)
- Birukov, A. (author)
- Campos, H. (author)
- Hirakawa, Y. (author)
- Imamura, F. (author)
- Jäger, S. (author)
- Lankinen, M. (author)
- Murphy, R. A. (author)
- Senn, M. (author)
- Tanaka, T. (author)
- Tintle, N. (author)
- Virtanen, J. K. (author)
- Yamagishi, K. (author)
- Allison, M. (author)
- Brouwer, I. A. (author)
- De Faire, U. (author)
- Eiriksdottir, G. (author)
- Ferrucci, L. (author)
- Forouhi, N. G. (author)
- Geleijnse, J. M. (author)
- Hodge, A. M. (author)
- Kimura, H. (author)
- Laakso, M. (author)
- van Westing, A. C. (author)
- Bandinelli, S. (author)
- Baylin, A. (author)
- Giles, G. G. (author)
- Gudnason, V. (author)
- Iso, H. (author)
- Lemaitre, R. N. (author)
- Ninomiya, T. (author)
- Post, W. S. (author)
- Psaty, B. M. (author)
- Salonen, J. T. (author)
- Schulze, M. B. (author)
- Tsai, M. Y. (author)
- Uusitupa, M. (author)
- Wareham, N. J. (author)
- Oh, S.-W. (author)
- Wood, A. C. (author)
- Harris, W. S. (author)
- Siscovick, D. (author)
- Mozaffarian, D. (author)
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- (creator_code:org_t)
- Wolters Kluwer, 2024
- 2024
- English.
- In: Circulation. - : Wolters Kluwer. - 0009-7322 .- 1524-4539. ; 149:4, s. 305-316
- Journal article (peer-reviewed)
Abstract
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- BACKGROUND: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium.METHODS: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were estimated using Cox regression and meta-analyzed. Interactions were assessed by analyzing product terms and calculating relative excess risk due to interaction.RESULTS: After multivariable adjustments, a significant interaction between low EPA/DHA and family history was observed (product term pooled RR, 1.09 [95% CI, 1.02-1.16]; P=0.01). The pooled relative risk of CVD associated with the combined exposure to low EPA/DHA, and family history was 1.41 (95% CI, 1.30-1.54), whereas it was 1.25 (95% CI, 1.16-1.33) for family history alone and 1.06 (95% CI, 0.98-1.14) for EPA/DHA alone, compared with those with neither exposure. The relative excess risk due to interaction results indicated no interactions.CONCLUSIONS: A significant interaction between biomarkers of low EPA/DHA intake, but not the other PUFA, and a family history was observed. This novel finding might suggest a need to emphasize the benefit of consuming oily fish for individuals with a family history of CVD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- biomarkers
- cardiovascular diseases
- fatty acids
- unsaturated
- medical history taking
- precision medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
- Laguzzi, F.
- Åkesson, A.
- Marklund, Matti
- Qian, F.
- Gigante, B.
- Bartz, T. M.
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- Bassett, J. K.
- Birukov, A.
- Campos, H.
- Hirakawa, Y.
- Imamura, F.
- Jäger, S.
- Lankinen, M.
- Murphy, R. A.
- Senn, M.
- Tanaka, T.
- Tintle, N.
- Virtanen, J. K.
- Yamagishi, K.
- Allison, M.
- Brouwer, I. A.
- De Faire, U.
- Eiriksdottir, G.
- Ferrucci, L.
- Forouhi, N. G.
- Geleijnse, J. M.
- Hodge, A. M.
- Kimura, H.
- Laakso, M.
- Risérus, Ulf, 19 ...
- van Westing, A. ...
- Bandinelli, S.
- Baylin, A.
- Giles, G. G.
- Gudnason, V.
- Iso, H.
- Lemaitre, R. N.
- Ninomiya, T.
- Post, W. S.
- Psaty, B. M.
- Salonen, J. T.
- Schulze, M. B.
- Tsai, M. Y.
- Uusitupa, M.
- Wareham, N. J.
- Oh, S.-W.
- Wood, A. C.
- Harris, W. S.
- Siscovick, D.
- Mozaffarian, D.
- Leander, K.
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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- Circulation
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- Karolinska Institutet
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